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  • Open Access


    In-Depth Study of Potential-Based Routing and New Exploration of Its Scheduling Integration

    Jihoon Sung1, Yeunwoong Kyung2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2891-2911, 2024, DOI:10.32604/cmes.2024.051772

    Abstract Industrial wireless mesh networks (WMNs) have been widely deployed in various industrial sectors, providing services such as manufacturing process monitoring, equipment control, and sensor data collection. A notable characteristic of industrial WMNs is their distinct traffic pattern, where the majority of traffic flows originate from mesh nodes and are directed towards mesh gateways. In this context, this paper adopts and revisits a routing algorithm known as ALFA (autonomous load-balancing field-based anycast routing), tailored specifically for anycast (one-to-one-of-many) networking in WMNs, where traffic flows can be served through any one of multiple gateways. In essence, the… More >

  • Open Access


    Evaluations of Chris-Jerry Data Using Generalized Progressive Hybrid Strategy and Its Engineering Applications

    Refah Alotaibi1, Hoda Rezk2, Ahmed Elshahhat3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3073-3103, 2024, DOI:10.32604/cmes.2024.050606

    Abstract A new one-parameter Chris-Jerry distribution, created by mixing exponential and gamma distributions, is discussed in this article in the presence of incomplete lifetime data. We examine a novel generalized progressively hybrid censoring technique that ensures the experiment ends at a predefined period when the model of the test participants has a Chris-Jerry (CJ) distribution. When the indicated censored data is present, Bayes and likelihood estimations are used to explore the CJ parameter and reliability indices, including the hazard rate and reliability functions. We acquire the estimated asymptotic and credible confidence intervals of each unknown quantity. More >

  • Open Access


    Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2/STAT3 signaling pathway


    BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074

    Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

  • Open Access


    Physiological Response Mechanism and Drought Resistance Evaluation of Passiflora edulis Sims under Drought Stress

    Binyang Zhao1, Fengchan Wu2, Guojun Cai3, Peiyu Xi2, Yulin Guo2, Anding Li2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1345-1363, 2024, DOI:10.32604/phyton.2024.050950

    Abstract In order to explore the response mechanism of Passiflora edulis Sims to drought stress, the changes in morphological and physiological traits of Passiflora edulis Sims under different drought conditions were studied. A total of 7 germplasm resources of Passiflora edulis Sims were selected and tested under drought stress by the pot culture method under 4 treatment levels: 75%–80% (Control, CK) of maximum field water capacity, 55%–60% (Light Drought, LD) of maximum field water capacity, i.e., mild drought, 40%–45% (Moderate Drought, MD) of maximum field water capacity, i.e., moderate drought and 30%–35% (Severe Drought, SD) of maximum field water… More >

  • Open Access


    Multiscale and Auto-Tuned Semi-Supervised Deep Subspace Clustering and Its Application in Brain Tumor Clustering

    Zhenyu Qian1, Yizhang Jiang1, Zhou Hong1, Lijun Huang2, Fengda Li3, KhinWee Lai6, Kaijian Xia4,5,6,*

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4741-4762, 2024, DOI:10.32604/cmc.2024.050920

    Abstract In this paper, we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering (MAS-DSC) algorithm, aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data, particularly in the field of medical imaging. Traditional deep subspace clustering algorithms, which are mostly unsupervised, are limited in their ability to effectively utilize the inherent prior knowledge in medical images. Our MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process, thereby enhancing the discriminative power of the feature representations. Additionally, the multi-scale feature extraction… More > Graphic Abstract

    Multiscale and Auto-Tuned Semi-Supervised Deep Subspace Clustering and Its Application in Brain Tumor Clustering

  • Open Access


    Knockdown of SLC34A2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Invasion

    Yanhua Li*1, Xia Chen†1, Hong Lu*

    Oncology Research, Vol.24, No.6, pp. 511-519, 2016, DOI:10.3727/096504016X14719078133483

    Abstract The gene solute carrier family 34 (sodium phosphate), member 2 (SLC34A2), is a member of the SLC34 family. Increasing evidence suggests that SLC34A2 is involved in the development of many human carcinomas. However, its role in hepatocellular carcinoma (HCC) is still unclear. Therefore, in this study we investigated the role of SLC34A2 in HCC and explored the underlying mechanism. We found that the expression of SLC34A2 is upregulated in HCC cell lines. Knockdown of SLC34A2 obviously inhibited HCC cell proliferation, migration/invasion, and the epithelial–mesenchymal transition (EMT) phenotype. Furthermore, knockdown of SLC34A2 significantly inhibited the expression More >

  • Open Access


    Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits the Proliferation and Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma Cells

    Xue-fei Jin, Hai Li, Shi Zong, Hong-yan Li

    Oncology Research, Vol.24, No.6, pp. 477-485, 2016, DOI:10.3727/096504016X14685034103716

    Abstract Collagen triple helix repeat containing-1 (CTHRC1), a secreted glycoprotein, is frequently upregulated in human cancers. However, the functional role of CTHRC1 in renal cell carcinoma (RCC) remains unclear. Thus, the aim of this study was to explore the role of CTHRC1 in RCC. Our results demonstrated that CTHRC1 was upregulated in RCC tissues and cell lines. Knockdown of CTHRC1 significantly inhibits the proliferation in RCCs. Furthermore, knockdown of CTHRC1 significantly inhibited the epithelial-to-mesenchymal transition (EMT) process in RCCs, as well as suppressed RCC cell migration and invasion. Mechanistically, knockdown of CTHRC1 inhibited the expression of More >

  • Open Access


    RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells

    Gaowu Hu*, Ye Xu*, Wenquan Chen*, Jiandong Wang, Chunying Zhao†1, Ming Wang*1

    Oncology Research, Vol.24, No.6, pp. 455-461, 2016, DOI:10.3727/096504016X14685034103635

    Abstract Breast cancer is a highly prevalent disease affecting women. The association of IQ motif containing GTPaseactivating protein 3 (IQGAP3) and breast cancer is poorly defined. Here we reported that IQGAP3 is a key regulator of cell proliferation and metastasis during breast cancer progression. The expression of IQGAP3 was significantly increased in breast tissues compared to nontumor tissues at both protein and mRNA levels. Furthermore, IQGAP3 had a high expression level in ZR-75-30 and BT474 compared to other breast cancer cell lines. Depletion of IQGAP3 through RNA interference in ZR-75-30 and BT474 significantly inhibited cell proliferation. More >

  • Open Access


    Knockdown of SPOCK1 Inhibits the Proliferation and Invasion in Colorectal Cancer Cells by Suppressing the PI3K/Akt Pathway

    Ping Zhao*, Hai-Tao Guan, Zhi-Jun Dai, Yu-Guang Ma, Xiao-Xu Liu, Xi-Jing Wang

    Oncology Research, Vol.24, No.6, pp. 437-445, 2016, DOI:10.3727/096504016X14685034103554

    Abstract Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 1 (SPOCK1), known as testican-1, were found to be involved in the development and progression of tumors. However, in colorectal cancer (CRC), the expression pattern of SPOCK1 and its functional role remain poorly investigated. In the present study, we explored the role of SPOCK1 in CRC. Our results demonstrated that SPOCK1 is overexpressed in CRC cell lines. SPOCK1 silencing significantly inhibited the proliferation in vitro and the tumor growth in vivo. Furthermore, SPOCK1 silencing significantly attenuated the migration/invasion by reversing the EMT process in CRC cells. Finally, knockdown More >

  • Open Access


    Impact of Exercise on Depression in Older Adults: Potential Benefits, Risks, and Appropriate Application Strategies

    Xingbin Du1,2, Jianda Kong3,*

    International Journal of Mental Health Promotion, Vol.26, No.5, pp. 345-350, 2024, DOI:10.32604/ijmhp.2024.049764

    Abstract As the global elderly population increases, depression within this group has become a significant public health concern. Although exercise has been recognized for its potential to improve depression in the elderly, the benefits, risks, and implementation strategies remain contentious. This review attempts to examine the impact of exercise on depression in older adults, including potential benefits, risks, and suggestions for application. Our analysis highlights the benefits of aerobic and resistance training, which can significantly alleviate depressive symptoms and enhance overall quality of life. Despite these benefits, the review acknowledges the complexity of the exercise-depression interaction More >

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