Moo Hyun Kim¹, Yongdae Yoon², Chang Wan Kim¹, Jun-Won Lee³, Bhupendra Regmi², Saher Fatima², Moon Young Kim^2,3, Soon Koo Baik^2,3, Pil Young Jung^1,*, Young Woo Eom^2,*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.076364 - 09 June 2026

Abstract Background: Although transforming growth factor-β (TGF-β) drives hepatic stellate cell activation and fibrogenesis, the mechanisms by which 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates these processes in TGF-β1-activated hepatic stellate cells remain to be determined. Therefore, we investigated whether TPA alleviates fibrosis in TGF-β1-treated hepatic stellate cells and regulates both canonical and non-canonical pathways. Further, we assessed whether inhibitors of these pathways similarly affect proliferation and fibrosis in LX-2 cells. Methods: LX-2 hepatic stellate cells were used as the experimental model. Cells were treated with TPA, TGF-β, or TGF-β plus TPA, and Yes-associated protein (YAP) and protein kinase B (PKB;… More >

Yalin Aygun^1,*, Sakir Tufekci¹, Goktug Norman¹, Burak Canpolat², Fatma Hilal Yagin³, Sacide Tufekci⁴, Cemil Colak⁵, Burak Yagin⁵, Huseyin Gurer⁶, Hulya Berktas¹, Emek Guldogan⁵, Matheus Santos de Sousa Fernandes⁷, Đina Škulić⁸, Larisa Draščić Šarinić⁸

International Journal of Mental Health Promotion, Vol.28, No.5, 2026, DOI:10.32604/ijmhp.2026.078673 - 28 May 2026

Abstract Backgrounds: Children’s mental ill health has risen worldwide in recent years, placing increasing emotional demands not only on autistic children but also on their families. A holistic perspective on supportive therapies besides medical treatment is essential. There is a growing need for research and practice that explore equine-assisted therapy through innovative relational frameworks. This qualitative study had two main aims: first, to understand how parents perceived the social and emotional benefits of their autistic child’s involvement in equine-assisted therapy; and second, to explore how parents experienced positive resonance with their child during simultaneous parent–child involvement in… More >

Shaowei Zhang^1,2,#, Bingbing Li^3,#, Xiaogai Zhao^2,#, Guoqiang Fan^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.081526 - 27 May 2026

Abstract Growth regulatory factor (GRF) genes play a crucial role in plant growth and development, reproduction, metabolism, and stress resistance. In this study, we conducted a genome-wide integrated analysis of transcriptome and miRNA expression profiles in Paulownia fortunei challenged by phytoplasma infection, with a specific focus on elucidating the functional landscape of the PfGRF transcription factor (TF) family. A comprehensive investigation was conducted on the PfGRF TF family. A total of 16 PfGRF genes were identified in this study, among which 13 were located on the chromosomes of P. fortunei. They were divided into six groups based on amino acid… More >

Abdul Ghafoor^1,*, Muhammad Munir^2,*, Khalid Turk¹, Muhammad Tahir³, Umair Riaz⁴, Adnan Mustafa⁵

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.080990 - 27 May 2026

Abstract Agricultural systems increasingly face interacting abiotic and biotic stresses driven by climate change and soil degradation. Plant performance under such conditions is determined by coordinated networks of functional traits governing resource acquisition, allocation, and defense. These traits also structure plant-associated microbiomes, whose activities influence nutrient cycling, stress buffering, and disease suppression. This review synthesizes current evidence that agricultural nanomaterials enhance crop stress resilience primarily by reprogramming plant functional trait networks and, through them, modulating microbiome dynamics. We analyze how nanomaterial physicochemical properties including size, surface chemistry, dissolution behavior, and redox activity determine their bioavailability and… More >

Sijun Bao¹, Yingping Chen^1,2,3, Xiaoqiang Wei^1,2,3, Long Tan^1,2,3, Lihui Wang^1,2,3,*

Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.080248 - 27 May 2026

Abstract This study aimed to elucidate the effects of varying seedling ages at planting on the agronomic traits and nutrient content of stem lettuce. The early-maturing variety “WS120” and the late-maturing variety “WS1” were employed as experimental materials. Four seedling age treatments were established at 20, 25, 30, and 35 d. By measuring the agronomic traits and nutrient content of the stem lettuce, we employed correlation analysis, principal component analysis, cluster analysis, and the membership function method for a comprehensive evaluation. This study aims to elucidate the optimal planting age for stem lettuce in plateau regions.… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085502 - 21 May 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085239 - 21 May 2026

Abstract This article has no abstract. More >

Boqi Zhou^1,2,3, Liping Shen^2,3, Xiaojie Lu^1,2,3,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.079463 - 21 May 2026

Abstract Objectives: Gamma-aminobutyric acid type B (GABAB) receptors are involved in tumor progression, and baclofen exerts broad-spectrum antitumor effects in various cancers. Nevertheless, its specific function and underlying molecular mechanisms in glioma are still largely unclear. This study aimed to evaluate the effects of baclofen on glioma cells and elucidate the associated signaling pathways. Methods: The antitumor effects of baclofen were evaluated in glioma cell lines, and its underlying molecular mechanisms were explored using transcriptome sequencing integrated with Western blotting. The in vivo antitumor efficacy of baclofen was further verified in animal models. Results: In vitro functional assays revealed that… More >

Jun Wang¹, Qian Fang^1,*, Weiguo He², Yanxin Chen¹, Qizhao You¹

Structural Durability & Health Monitoring, Vol.20, No.3, 2026, DOI:10.32604/sdhm.2025.076570 - 18 May 2026

Abstract This study presents a comprehensive investigation into the deformation mechanisms of existing metro stations subjected to the simultaneous construction of adjacent foundation pits and underground tunnels. A refined three-dimensional numerical modeling framework is developed to simulate the entire construction process, capturing the complex interactions between excavation activities and station structures. The modeling encompasses deep excavation, side-crossing, and overcrossing passage construction, and the staged installation of support systems. Six construction schemes, varying in excavation sequence, interlayer thickness (clear distance), and passageway layout, are systematically analyzed. Field monitoring data are incorporated to validate the numerical models, enhancing… More >

Computers, Materials & Continua Editorial Office

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.083417 - 08 May 2026

Abstract This article has no abstract. More >