FEI SHA¹, DAISHAN XIN², JUN XU³, ZHIWEI ZHENG¹, WENXIN LIN¹, XIAORUI CAI¹, FEI LIN³, MINGHAO ZHENG^1,*, JIAOLING CHEN^1,*

BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188

Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western blot, and immunofluorescence assays. Then… More > Graphic Abstract

Irfan Haider¹, Muhammad Attique Khan^1,*, Muhammad Nazir¹, Taerang Kim², Jae-Hyuk Cha²

Computer Systems Science and Engineering, Vol.48, No.2, pp. 529-554, 2024, DOI:10.32604/csse.2023.042080

Abstract Fruit infections have an impact on both the yield and the quality of the crop. As a result, an automated recognition system for fruit leaf diseases is important. In artificial intelligence (AI) applications, especially in agriculture, deep learning shows promising disease detection and classification results. The recent AI-based techniques have a few challenges for fruit disease recognition, such as low-resolution images, small datasets for learning models, and irrelevant feature extraction. This work proposed a new fruit leaf leaf leaf disease recognition framework using deep learning features and improved pathfinder optimization. Three fruit types have been employed in this work for… More >

Wenjie Li¹, Yucheng Gao², Guoqing Liu², Rongkai Hao², Meijie Zhang², Xiaotian Li^1,*

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 83-92, 2024, DOI:10.32604/ijmhp.2023.042014

Abstract As adolescent mental health problems are becoming a more serious issue globally, this paper explores the relationship of physical activity in adolescents and its frequency on mental health as well as examines the mediating effects of life satisfaction and self-rated health in order to provide a reference for the promotion of mental health in adolescents. A sample of 3578 Chinese high school students completed questionnaires assessing their mental health, physical activity frequency, life satisfaction, and self-rated health. The mean SCL-90 value for adolescents was found to be 1.629%, and 24.73% of adolescents had varying degrees of mental health issue. Increased… More >

WEIXUE WANG^#, TONGTONG WANG^#, YAN ZHANG, TING DENG, HAIYANG ZHANG^*, YI BA^*

Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

HUI SUN, MASANORI KAWANO^*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

Senjie Zhang^1,2, Jinbo Wang^2,*, Shan Zhou², Jingpei Wang^2,3, Zhenyong Zhang^4,*, Ruixue Wang²

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1027-1047, 2024, DOI:10.32604/cmc.2023.046355

Abstract The globalization of hardware designs and supply chains, as well as the integration of third-party intellectual property (IP) cores, has led to an increased focus from malicious attackers on computing hardware. However, existing defense or detection approaches often require additional circuitry to perform security verification, and are thus constrained by time and resource limitations. Considering the scale of actual engineering tasks and tight project schedules, it is usually difficult to implement designs for all modules in field programmable gate array (FPGA) circuits. Some studies have pointed out that the failure of key modules tends to cause greater damage to the… More >

S. Sofana Reka¹, Ankita Bagelikar², Prakash Venugopal^2,*, V. Ravi², Harimurugan Devarajan³

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 781-794, 2024, DOI:10.32604/cmc.2023.043369

Abstract The freshness of fruits is considered to be one of the essential characteristics for consumers in determining their quality, flavor and nutritional value. The primary need for identifying rotten fruits is to ensure that only fresh and high-quality fruits are sold to consumers. The impact of rotten fruits can foster harmful bacteria, molds and other microorganisms that can cause food poisoning and other illnesses to the consumers. The overall purpose of the study is to classify rotten fruits, which can affect the taste, texture, and appearance of other fresh fruits, thereby reducing their shelf life. The agriculture and food industries… More >

Rana Muhammad Zulqarnain¹, Hafiz Khalil ur Rehman², Imran Siddique³, Hijaz Ahmad^4,5, Sameh Askar⁶, Shahid Hussain Gurmani^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1863-1892, 2024, DOI:10.32604/cmes.2023.031480

Abstract This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach, the Einstein hybrid structure of q-rung orthopair fuzzy soft set. This approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations, especially in areas affected by floods. Compared to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set, the q-rung orthopair fuzzy soft set (q-ROFSS) adequately incorporates unclear and indeterminate facts. The major objective of this investigation is to formulate the q-rung orthopair fuzzy soft Einstein hybrid weighted average (q-ROFSEHWA)… More >

Jingjing Tian¹, Shenglin Mo^1,*, Feng Zhao¹, Xiaoqiang Chen²

Energy Engineering, Vol.121, No.2, pp. 439-459, 2024, DOI:10.32604/ee.2023.029956

Abstract In this paper, an improved sag control strategy based on automatic SOC equalization is proposed to solve the problems of slow SOC equalization and excessive bus voltage fluctuation amplitude and offset caused by load and PV power variations in a stand-alone DC microgrid. The strategy includes primary and secondary control. Among them, the primary control suppresses the DC microgrid voltage fluctuation through the Ⅰ and Ⅱ section control, and the secondary control aims to correct the P-U curve of the energy storage system and the PV system, thus reducing the steady-state bus voltage excursion. The simulation results demonstrate that the… More >

Junhui Li¹, Haotian Zhang¹, Cuiping Li^1,*, Xingxu Zhu¹, Ruitong Liu², Fangwei Duan², Yongming Peng³

Energy Engineering, Vol.121, No.2, pp. 291-313, 2024, DOI:10.32604/ee.2023.027593

Abstract In the existing power system with a large-scale hydrogen storage system, there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system. In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation, and speed up the process of electric-hydrogen-electricity conversion. This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit, and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen… More >