CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

Cheng Hou¹, Xiaochao Jin², Xueling Fan^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012325

Abstract The over-deterministic method (ODM) is dedicated to calculate a small set of unknown coefficients from a large system of equations, by making use of a large number of data points. A displacement over-deterministic method (DODM) developed by Ayatollahi et al. [1] has been employed by for calculating the stress intensity factors (SIFs) as well as the coefficients of the higher-order terms in the Williams’ series expansions for cracked bodies. The ODM provides a great idea to easily obtain fracture parameters, combine with finite element method (FEM).
In our work, a stress over-deterministic method (SODM) has been… More >

Ruiqi Pan¹, Wei Xiong², Liang Hao^1,*, Yan Li^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011651

Abstract As metal additive manufacturing (MAM) becomes more widely used in engineering, an increasing number of novel lattice structures are being developed. However, most recently developed lattice structures do not match the requirement of MAM efficiently. Based on the Design for Additive Manufacturing (DfAM), comparing the mainstream implicit and explicit modelling methods, it is proposed to introduce a Subdivisional (Sub-D) modelling method to model lattice structures with better modelling versatility, 3D printability, and mechanical properties. To this end, a novel negative Poisson's ratio (NPR) structure is developed as an example to demonstrate the efficient and wide… More >

Qinghao Zhang¹, Yijie Yang¹, Jiong Wu¹, Hongru Li¹, Yuan Li¹, Zuran Li^2,*, Yongmei He^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2613-2628, 2024, DOI:10.32604/phyton.2024.056014 - 30 October 2024

Abstract In the present study, an indoor potting experiment was conducted to study the effects of enhanced UV-B radiation and Magnaporthe oryzae on the growth, stomatal structure, photosynthesis, and endogenous hormone contents of a traditional rice cultivar Baijiaolaojing in the Yuanyang terraces of Yunnan Province. In addition, the relationships between these parameters and disease indices were analyzed. We aimed to clarify the response of the photosynthetic physiology of rice under the combined stress of UV-B radiation and M. oryzae. Compared with the M. oryzae infection treatment, all the treatments, including M. oryzae infection before (MBR), simultaneously with (MSR), and after… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1829-1829, 2024, DOI:10.32604/or.2024.056904 - 16 October 2024

Abstract This article has no abstract. More >

RONG LIU^1,#, SHENG LI^2,#, SITU XIONG², FUCUN ZHENG², XIANGPENG ZHAN², JIN ZENG², BIN FU², SONGHUI XU², SHAOXING ZHU^1,*, RU CHEN^1,*

Oncology Research, Vol.32, No.11, pp. 1733-1746, 2024, DOI:10.32604/or.2024.050851 - 16 October 2024

Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >

LICHEN XU^1,2, PAN ZHANG^3,*, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.32, No.11, pp. 1777-1789, 2024, DOI:10.32604/or.2024.047704 - 16 October 2024

Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >

Qianqian Zhang¹, Yingmei Li^1,*, Jianjun Zhan^2,*, Shan Chen¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1251-1273, 2024, DOI:10.32604/cmc.2024.053892 - 15 October 2024

Abstract This research focuses on improving the Harris’ Hawks Optimization algorithm (HHO) by tackling several of its shortcomings, including insufficient population diversity, an imbalance in exploration vs. exploitation, and a lack of thorough exploitation depth. To tackle these shortcomings, it proposes enhancements from three distinct perspectives: an initialization technique for populations grounded in opposition-based learning, a strategy for updating escape energy factors to improve the equilibrium between exploitation and exploration, and a comprehensive exploitation approach that utilizes variable neighborhood search along with mutation operators. The effectiveness of the Improved Harris Hawks Optimization algorithm (IHHO) is assessed by… More >

Lixiang Dang¹, Yanwen Zeng¹, Wei Duan^1,*, Yan Zhang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012173

Abstract In order to regulate the multi-scale structure of Ti-6Al-4V formed by the SLM (selective laser melting) process, this study uses the method of combining numerical simulations with experiments to investigate the effects of SLM process parameters on the phase composition, micro- and meso-structures, and their distribution of Ti-6Al-4V. The study shows that the SLM-formed Ti-6Al-4V is mainly composed of α/α' phases. Horizontally, the specimens at a 0° phase angle mainly show a striped pattern, while the specimens at 67° and 90° phase angles will show a tessellated pattern. Vertically, the specimens at 0°, 67°, and More >

Bo Hwan Kim^1,#, Sheikh Mansoor^2,#, Gyung Deok Han³, Ji Eun Park⁴, Wook Kim^1,*, Yong Suk Chung^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2339-2347, 2024, DOI:10.32604/phyton.2024.056439 - 30 September 2024

Abstract Recognizing the variation of genetic resources is the first step in selection. One of the most important variations in grain crops is the uniformity of seed grain weight, which can be converted into seed size. However, it has been challenging since it needs high labor costs and time to measure it on a large scale. The current study used an image analysis technique to measure the grain seed area of about 100 seeds per accession with 64 germplasm of Tartary buckwheat (Fagopyrum tataricum) to study variation among and within them. To understand the nature of variation, More >