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  • Open Access

    REVIEW

    COVID-19: Review on Its Etiology, Pathogenesis, and Existence in Humans

    VIVEK KUMAR, VISHNU AGARWAL*

    BIOCELL, Vol.44, No.4, pp. 461-467, 2020, DOI:10.32604/biocell.2020.011090 - 24 December 2020

    Abstract The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December 2019. Also known as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), the disease associated with SARSCoV-2 is even called COVID-19. The infection is said to have originated from the bat community and transmitted to humans through an intermediate host (yet unknown) in Wuhan, in the Hubei region of China. COVID-19 is having a pulverizing impact on the scientific community. As of August 13, 2020, the number of confirmed cases had reached up to 20,439,814 and the death More >

  • Open Access

    REVIEW

    Functions of ULK1 in autophagy and non-autophagy pathways and its implications in human physiology and disease

    LINNA TAN1,2, YUYONG TAN1,2, DELIANG LIU1,2,*

    BIOCELL, Vol.44, No.4, pp. 535-543, 2020, DOI:10.32604/biocell.2020.09171 - 24 December 2020

    Abstract ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which, through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the regulation More >

  • Open Access

    ARTICLE

    Sawdust Short Fiber Reinforced Epoxidized Natural Rubber: Insight on Its Mechanical, Physical, and Thermal Aspects

    O. S. Dahham1, N. Z. Noriman1,2,*, H. Jaya1, R. Hamzah1, M. U. Umar2,3, I. Johari4

    Journal of Renewable Materials, Vol.8, No.12, pp. 1633-1645, 2020, DOI:10.32604/jrm.2020.011377 - 12 November 2020

    Abstract In this work, Epoxidized natural rubber/sawdust short fiber (ENR-50/ SD) composites at different fiber content (5, 10, 15 and 20 phr) and size (fine size at 60–100 μm and coarse size at 10–20 mm) were prepared using two-roll mill and electrical-hydraulic hot press machine respectively. Curing characteristics, water uptake, tensile, morphological, physical, and thermal properties of the composites were investigated. Results indicated that the scorch time and cure time became shorter whereas torque improved as SD content increase. Though the decline of tensile strength and elongation at break values, modulus, hardness and crosslinking density have More >

  • Open Access

    ARTICLE

    Genome-Wide Identification of Candidate Genes Associated with β-glucan Traits in a Hulled and Hulless Barley (Hordeum vulgare L.) Population

    Longhua Zhou1,2,#, Ting He1,2,#, Guimei Guo1,2, Jing Li1,2, Ruiju Lu1,2, Yingbo Li1,2,*, Chenghong Liu1,2,*

    Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 987-997, 2020, DOI:10.32604/phyton.2020.011728 - 09 November 2020

    Abstract Barley grain is a valuable source of β-glucan, which is an important component of dietary fiber with significant human health benefits. Although the genetic basis of β-glucan biosynthesis has been widely studied, a genome-wide association study (GWAS) is still required for a scan of the candidate genes related to the complex quantitative trait based on the high-quality barley reference genome. In this study, a GWAS was conducted using a population composed of 87 barley landraces (39 hulled and 48 hulless, β-glucan from 2.07% to 6.56%) with 191,098 nucleotide polymorphisms (SNPs) markers to cover the chromosomes with the… More >

  • Open Access

    REVIEW

    Therapeutic Applications of Naringenin, a Flavanone Enriched in Citrus Fruits, for Disorders beyond Diabetes

    Jaswinder Kaur1, Manish Vyas2, Joginder Singh1, Ram Prasad3,*, Jeena Gupta1,*

    Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 795-803, 2020, DOI:10.32604/phyton.2020.09420 - 09 November 2020

    Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin More >

  • Open Access

    ARTICLE

    Event Trigger Recognition Based on Positive and Negative Weight Computing and its Application

    Tao Liao1,‡, Weicheng Fu1,†, Shunxiang Zhang1,*, Zongtian Liu2,§

    Computer Systems Science and Engineering, Vol.35, No.5, pp. 311-319, 2020, DOI:10.32604/csse.2020.35.311

    Abstract Event trigger recognition is a sub-task of event extraction, which is important for text classification, topic tracking and so on. In order to improve the effectiveness of using word features as a benchmark, a new event trigger recognition method based on positive and negative weight computing is proposed. Firstly, the associated word feature, the part-of-speech feature and the dependency feature are combined. Then, the combination of these three features with positive and negative weight computing is used to identify triggers. Finally, the text classification is carried out based on the event triggers. Findings from our More >

  • Open Access

    ARTICLE

    Silencing of long non-coding RNA CCHE1 inhibits the ovarian cancer SKOV3 cell invasion and migration and inactivates the p38-MAPK signaling pathway

    HONGWEI CHEN#, XUAN SONG#, HEMEI LI*

    BIOCELL, Vol.44, No.3, pp. 345-351, 2020, DOI:10.32604/biocell.2020.08944 - 22 September 2020

    Abstract Ovarian cancer (OC) is a major cause of cancer-related deaths among gynaecological malignancies. Emerging studies suggest that the long non-coding RNA (lncRNA) may be the potential biomarker for the diagnosis and prognosis of the cancer. The current study was carried out to investigate the role of lncRNA CCHE1 silencing in OC cell invasion and migration. Expression of lncRNA CCHE1 in normal ovarian cell Hose and OC cell lines HO 8910, A2780 and SKOV3 was detected. LncRNA were transfected with siRNA, and then the proliferation of cells was detected by using MTT assay. Cell invasion and… More >

  • Open Access

    ARTICLE

    Human umbilical cord blood mesenchymal stem cells conditioned media inhibits hypoxia-induced apoptosis in H9c2 cells by activation of the survival protein Akt

    XUHE GONG1, GUANGPU FAN2, HUI LIU1, SIJIA WANG3, RONGCHONG HUANG1,*

    BIOCELL, Vol.44, No.3, pp. 329-336, 2020, DOI:10.32604/biocell.2020.09639 - 22 September 2020

    Abstract This work aimed to study the beneficial role of human umbilical cord blood-derived mesenchymal stem cellconditioned medium (MSC-CM) in hypoxia-induced apoptosis in H9c2 cardiomyoblasts, in which the serine/heroine kinases (Akt) pathway would be involved. For this, CM was collected by culturing MSCs in serum-free DMEM medium for 24 h, and paracrine factors were analyzed by protein chip. H9c2 cells were divided into the following groups: control group, hypoxia group, MSC-CM intervention group (CM group), MSC-CM + Akt phosphorylation inhibitor (LY294002) group (LY group). Apoptosis of the H9c2 cells was tested with chromatin dye Hoechst 33342… More >

  • Open Access

    ARTICLE

    The Development of Generalized Public Bicycles in China and Its Role in the Urban Transportation System

    Yang Tang1,*, Weiwei Liu1, Yihao He1, Yuelin Zhang2, Fulong Zhang2

    Journal on Internet of Things, Vol.2, No.3, pp. 101-107, 2020, DOI:10.32604/jiot.2020.010108 - 16 September 2020

    Abstract Public bicycle service has experienced 15 years of development in Chinese cities, and mainland China is the world's largest public bicycle market. Choosing to use public bicycles is becoming more and more a daily habit of residents. Broadly speaking, public bicycles in Chinese cities include both public bikes with service stations and shared bicycles without service stations. Based on historical review and years of accumulated data, this paper reviews the development of general public bicycles in Chinese cities in the past 15 years. And the role of general public bicycles in China’s urban transportation system More >

  • Open Access

    ARTICLE

    Reversible Data Hiding in Encrypted Images Based on Prediction and Adaptive Classification Scrambling

    Lingfeng Qu1, Hongjie He1, Shanjun Zhang2, Fan Chen1, *

    CMC-Computers, Materials & Continua, Vol.65, No.3, pp. 2623-2638, 2020, DOI:10.32604/cmc.2020.09723 - 16 September 2020

    Abstract Reversible data hiding in encrypted images (RDH-EI) technology is widely used in cloud storage for image privacy protection. In order to improve the embedding capacity of the RDH-EI algorithm and the security of the encrypted images, we proposed a reversible data hiding algorithm for encrypted images based on prediction and adaptive classification scrambling. First, the prediction error image is obtained by a novel prediction method before encryption. Then, the image pixel values are divided into two categories by the threshold range, which is selected adaptively according to the image content. Multiple high-significant bits of pixels More >

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