Abdullah Alahmari^1,2, Rabea Akram^1,2, Michael Maalouf³, Abdulelah Elsayed⁴, Armand Zini^1,5,*

Canadian Journal of Urology, Vol.32, No.4, pp. 317-323, 2025, DOI:10.32604/cju.2025.064517 - 29 August 2025

Abstract Background: Testicular sperm aspiration (TESA) is a minimally invasive testicular sperm retrieval technique that has been utilized in the treatment of male factor infertility. We sought to evaluate sperm retrieval outcomes of primary and redo TESA in men with severe oligoasthenoteratozoospermia (OAT) and obstructive azoospermia (OA). Methods: This is a retrospective analysis of consecutive TESAs (primary and redo) for men with severe OAT and OA performed between January 2011 and August 2022 at a high-volume infertility center. We compared TESA outcomes in men with severe OAT to those with OA and compared outcomes of men… More >

Marc Goldstein

Canadian Journal of Urology, Vol.31, No.5, pp. 11971-11971, 2024

Abstract This article has no abstract. More >

AMOURA M. ABOU-EL-NAGA¹, SHAKER A. MOUSA², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, ENGY S. FAHIM¹

BIOCELL, Vol.48, No.12, pp. 1835-1837, 2024, DOI:10.32604/biocell.2024.054569 - 30 December 2024

Abstract This article has no abstract. More >

Dylan Buller¹, Brooke Harnisch¹, Vikram Lyall², Michael Goltzman¹, Evelyn Neuber³, Alison Bartolucci³, Stanton Honig^1,4

Canadian Journal of Urology, Vol.30, No.4, pp. 11613-11618, 2023

Abstract Introduction: To evaluate patient preference for sperm disposition in case of death based on demographic factors and infertility etiology.
Materials and methods: This retrospective cohort study was performed at a university hospital-affiliated fertility center. Charts of 550 men undergoing cryopreservation for assisted reproductive technologies (ART) between 2016-2019 were reviewed to create a descriptive dataset. Patients previously signed consent forms stating their preference for sperm transfer to their partner or disposal in the event of their subsequent death. Patients undergoing sperm cryopreservation for the purpose of ART were analyzed to assess associations between demographic characteristics and etiology of… More >

Larry I. Lipshultz

Canadian Journal of Urology, Vol.30, No.6, pp. 11713-11713, 2023

Abstract This article has no abstract. More >

YANSHUANG ZHAO, WANXI YANG^*

BIOCELL, Vol.47, No.8, pp. 1709-1725, 2023, DOI:10.32604/biocell.2023.030379 - 28 August 2023

Abstract The phosphoinositide-3-kinase/Akt (PI3K/AKT) signaling pathway is crucial for Sertoli cell development and completing spermatogenesis. Its main role is to promote proliferation and inhibit apoptosis. Many factors activate the PI3K/AKT pathway, like hormones, such as follicle stimulating hormone (FSH), androgen, estrogen, insulin to name a few. Many of these factors have receptors inside or on the surface of Sertoli cells (SCs). This review summarizes how these hormones directly regulate the PI3K/AKT signaling pathway in SCs, which in turn affects SC proliferation and differentiation. Further, hormone-mediated PI3K/AKT signaling also stimulates SC secretion, which is essential for germ More >

XIAOXIA WANG^1,#, ZHONGYUAN YAO^1,2,#, DI LIU¹, CHUNHONG YU^3,*, HUI LI^1,3,*

BIOCELL, Vol.46, No.8, pp. 1803-1806, 2022, DOI:10.32604/biocell.2022.019731 - 22 April 2022

Abstract Each stage of embryonic development, including normal gamete maturation, fertilization, zygotic genome activation, and cleavage, is crucial for human reproduction. Early embryo arrest is a common phenomenon. It is estimated that about 40%–70% of human embryos are arrested at early developmental stages. However, the exact mechanism remains largely uncertain. Embryos can be investigated in vitro by way of the development of in vitro fertilization/intracytoplasmic sperm injection. In addition to iatrogenic factors related to abnormal oocyte/embryo development, multiple gene mutations have been found to be involved in such phenotypes. Based on the knowledge of known etiological factors, several More >

AMOURA M. ABOU-EL-NAGA¹, SHAKER A. MOUSA², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, ENGY S. FAHIM¹

BIOCELL, Vol.46, No.2, pp. 535-545, 2022, DOI:10.32604/biocell.2022.017739 - 20 October 2021

Abstract Testicular damage is one of the most hazardous effects as it’s associated with azoospermia. Busulfan (Bu) is a highly toxic chemotherapeutic drug that affects testis. Thirty male Swiss albino mice divided into six groups of 5 animals each. Control (oral 0.9% saline daily for 75 days); Mel (20 mg/kg/day orally for 30 days); ZnO NPs (5 mg/kg/day i.p. for 30 days); BU (single i.p. injection of 40 mg/kg and then left for 45 days); BU + Mel (single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 More >

Kentaro Mori^1,*, Kotaro Kitaya², Tomomoto Ishikawa², Yutaka Hata³

Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 335-352, 2021, DOI:10.32604/iasc.2021.01010 - 16 June 2021

Abstract In infertility treatment, it is required to improve a success rate of the treatment. A purpose of this study is to develop a prediction system for pregnancy outcomes using ultrasonic images. In infertility treatment, it is typical to evaluate the endometrial shape by using ultrasonic images. The convolutional neural network (CNN) system developed in the current study predicted pregnancy outcome by velocity information. The velocity information has a movement feature of uterine. It is known that a uterine movement is deep related to infertility. Experiments compared the velocity-based and shape-based systems. The shape-based systems predict… More >

J.C. Trussell¹, Ava Delu¹, Robert J. Kiltz², Vladimir A. Kuznetsov¹

Canadian Journal of Urology, Vol.27, No.4, pp. 10306-10311, 2020

Abstract Introduction: Men with unexplained infertility (UI) should undergo an initial hormonal evaluation including serum FSH and total testosterone (TT). Unfortunately, there is no consensus regarding which TT cut point should be used to define hypogonadism in such men. To determine the best definition for hypogonadism, three different, literature-based TT cut points were used to assess associations between TT and semen parameters. The hypothesis was that the lowest TT cut point would associate with poorest sperm parameters.
Materials and methods: We performed an IRB-approved retrospective chart review of 247 consecutive males presenting for evaluation of male factor infertility.… More >