JU-YEON LEE¹, DAEUN MOON², JINU KIM^2,3,*

BIOCELL, Vol.49, No.1, pp. 79-92, 2025, DOI:10.32604/biocell.2024.058340 - 24 January 2025

Abstract The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses. This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases. EGFR signaling is essential for kidney function and repair mechanisms, and its dysregulation significantly impacts both acute and chronic kidney conditions. The review discusses the normal distribution of EGFR in kidney tubular segments, the mechanism of its activation and inhibition, and the therapeutic potential of EGFR-targeting antagonists and ligands. Additionally, it explores the pathophysiological characteristics observed More >

Suraj Pursnani, Necole M. Streeper

Canadian Journal of Urology, Vol.31, No.3, pp. 11911-11913, 2024

Abstract Drug-induced nephrolithiasis represents only 1%-2% of stone cases. Here we focus on drugs capable of crystallizing and forming stone, specifically phenazopyridine (Pyridium/Azo). This is a case of a patient who presented with a stone conglomerate in the right proximal ureter and underwent definitive treatment. Interestingly, the stone had a purple hue with FTIR spectroscopy showing stone composition of calcium oxalate (monohydrate and dihydrate) and a material resembling phenazopyridine. We retrospectively learned that she used multiple extended courses of phenazopyridine over 3 months. More >

Kennedy E. Okhawere¹, Ralph Grauer¹, Indu Saini¹, Iretiayo T. Joel¹, Alp Tuna Beksac², Oluwatoyin Ayo-Farai¹, Rutul Patel¹, Talia G. Korn¹, Kirolos N. Meilika¹, Najimdin Pedro¹, Ketan K. Badani¹

Canadian Journal of Urology, Vol.31, No.5, pp. 11992-12003, 2024

Abstract Introduction: We aim to identify factors associated with surgical refusal and non-surgical candidacy in clinical stage I kidney masses and to evaluate their impact on overall survival (OS).
Materials and methods: We conducted a retrospective cohort study using the National Cancer Database of patients with clinical stage I kidney cancer between 2004 and 2017. Logistic regression was used to determine baseline sociodemographic-, clinical-, and treatment facility-related factors associated with surgical refusal and non-surgical candidacy. Patients were 1.1 propensity score-matched and Cox regression analysis evaluated the impact of surgical refusal and non-surgical candidacy on OS.
Results: Compared to those… More >

Stephanie Aron, Anthony Galvez, Ryan Nasseri, Susana Berrios, Tyler Sheetz

Canadian Journal of Urology, Vol.31, No.6, pp. 12077-12080, 2024

Abstract Nephrolithiasis is one of the most common indications for surgery in patients with a horseshoe kidney. Robotic assisted surgery has become a staple in urologic practice, yet its application in stone management is largely undefined. We present a patient with a horseshoe kidney, who underwent a robotic-assisted laparoscopic pyelolithotomy (RPL) to treat a 3 cm stone burden. This procedure allowed for safe access that could not be obtained with percutaneous nephrolithotomy (PCNL) and stone removal without fragmentation, which would have been challenging with traditional laparoscopy. We advocate for the use of robotic-assisted laparoscopic pyelolithotomy in More >

RONG LIU^1,#, SHENG LI^2,#, SITU XIONG², FUCUN ZHENG², XIANGPENG ZHAN², JIN ZENG², BIN FU², SONGHUI XU², SHAOXING ZHU^1,*, RU CHEN^1,*

Oncology Research, Vol.32, No.11, pp. 1733-1746, 2024, DOI:10.32604/or.2024.050851 - 16 October 2024

Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >

YU TANG¹, WENXIAO HU^2,*, YAJUN PENG¹, XIANGDONG LING²

BIOCELL, Vol.48, No.10, pp. 1503-1516, 2024, DOI:10.32604/biocell.2024.052692 - 02 October 2024

Abstract Background: Podocyte injury is crucial in diabetic kidney disease (DKD) progression, and the mechanism remains unclear. The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression. However, more research is needed to explore Diosgenin in inhibiting-molecular mechanisms in the process of podocyte injury. Methods: The content of Diosgenin in HeShenwan was detected by High-Performance Liquid Chromatography-mass spectrometry (HPLC-MS) method. The podocyte injury model was constructed by high glucose (HG)-induced mpc5 cells. The Cell Counting Kit-8 (CCK-8) assay was utilized to evaluate the activity of mpc5 cells. Pyroptosis in mpc5 cells was… More > Graphic Abstract

KEWEI CHENG¹, LEI SHI¹, CAIWEN SHI¹, SHUANSHUAN XIE², CHANGHUI WANG^2,*

BIOCELL, Vol.48, No.8, pp. 1209-1221, 2024, DOI:10.32604/biocell.2024.049626 - 02 August 2024

Abstract Objective: To explore the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). Methods: Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7 (CBX7) in LUAD. The Cell Counting Kit-8, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling, Transwell, and wound-healing assays were carried out to assess the proliferative, apoptotic, invasive, and migrative capacities of the cells. Furthermore, the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay. A LUAD mice model was constructed by subcutaneous injection of A549 cells.… More >

Ali Altalbe^1,2,*, Abdul Rehman Javed³

Computer Systems Science and Engineering, Vol.48, No.4, pp. 1075-1081, 2024, DOI:10.32604/csse.2024.054179 - 17 July 2024

Abstract This article has no abstract. More >

BIN LI^1,2,3,#, YUCHENG SHENG^4,#, XIAOYING XU⁴, SHENGCUN WANG³, HONGYAN SONG³, JINGYUAN LI³, HAONAN JI¹, QINGHUA WANG³, XIAODI ZHOU^1,*, LONGJU QI^2,*

BIOCELL, Vol.48, No.4, pp. 601-611, 2024, DOI:10.32604/biocell.2024.047404 - 09 April 2024

Abstract Objective: Chronic kidney disease (CKD) is a progressive disorder characterized by intricate structural and functional alterations in the kidneys, attributable to diverse causative factors. Notably, the therapeutic promise of miR-145-5p in addressing renal pathologies has been discerned. This investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells (HGMCs) to stimulation with Angiotensin II (AngII). Materials and Methods: Cellular viability and the levels of inflammatory mediators were evaluated utilizing Cell Counting Kit-8 (CCK-8), quantitative real-time polymerase chain reaction (qRT-PCR), and western blot methodologies, both in the presence of… More >

KUNLUN LI¹, DANDAN LI², BARBOD HAFEZ^3,*, MOUNIR M. SALEM BEKHIT⁴, YOUSEF A. BIN JARDAN⁴, FARS KAED ALANAZI⁴, EHAB I. TAHA⁴, SAYED H. AUDA⁴, FAIQAH RAMZAN^5,*, MUHAMMAD JAMIL⁶

Oncology Research, Vol.32, No.4, pp. 737-752, 2024, DOI:10.32604/or.2023.042925 - 20 March 2024

Abstract Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that carries a substantial risk of morbidity and mortality. The MMP family assumes a crucial role in tumor invasion and metastasis. This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the… More >