Zhilong He^1,#, Jing Qin^1,#, Sixuan Wu^2,#, Xian Liang¹, Yu Liu¹, Jinfeng Qiu¹, Zhimin Li^2,*, Kai Hu^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070567 - 19 January 2026

Abstract Objective: The contribution of long non-coding RNAs (lncRNAs) associated with protein palmitoylation to the progression of hepatocellular carcinoma (HCC) remains largely unclear. This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC. Methods: RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas (TCGA). Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes. Univariate Cox regression was applied to select lncRNAs with prognostic value, followed by the construction of a predictive model using the… More >

Ahmed Ahmed¹, Bilal Farhan², Amr Alam-Eldin¹, Maged Amin Helmy¹, Mohammed Mostafa Hussein¹, Zakieldahshoury Mohamed¹, Hassaan A. Gad¹, Suraj Nayan Vodnala^3,*

Canadian Journal of Urology, Vol.32, No.5, pp. 483-490, 2025, DOI:10.32604/cju.2025.067228 - 30 October 2025

Abstract Background: As occurrence rates of pediatric ureteral stones have increased, evaluation of optimal treatment modalities has become imperative. This study’s primary goal is to compare outcomes between dusting and fragmentation techniques using Holmium:YAG (Ho:YAG) laser lithotripsy in children with ureteral stones. Methods: A prospective randomized study was conducted at Aswan University Hospitals from June 2023 to December 2024. One hundred children, under the age of 18, with single, mid- or distal, ureteral stones (5–20 mm) were randomized into two groups. Group A received laser dusting (0.2–0.6 J, 20–40 Hz), while Group B received fragmentation (0.8–1.5… More >

Demirhan Örsan Demir^1,*, Yusuf Gökkurt¹, Salih Bürlükkara², Turgay Kaçan¹, Ali Kaan Yıldız¹, Ufuk Bozkurt², Tolga Karakan¹

Canadian Journal of Urology, Vol.32, No.2, pp. 111-118, 2025, DOI:10.32604/cju.2025.063970 - 30 April 2025

Abstract Introduction: Surgeons typically prefer 270 µm and 272 µm laser probes in retrograde intrarenal surgery (RIRS) due to the reduced deflection capacity of flexible ureterorenoscopes when using larger probe diameters. This study aims to investigate the effects of 272 and 365 µm holmium laser probes on operative time, clinical efficacy, and complication rates in RIRS. Materials and Methods: A total of 285 patients with proximal ureteral or kidney stones who met the inclusion criteria were enrolled in the study. Patients were divided into two groups based on laser probe thickness: 272 µm and 365 µm. Stone-free… More >

Yash B. Shah¹, Brian H. Im¹, Aaron R. Hochberg¹, Elliott P. Freudenburg², James Jiang², Bruce M. Gao², Mihir S. Shah¹, Akhil K. Das^2,*

Canadian Journal of Urology, Vol.32, No.1, pp. 15-19, 2025, DOI:10.32604/cju.2025.064708 - 20 March 2025

Abstract Introduction: Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent, endoscopic management option for benign prostatic hyperplasia (BPH). HoLEP offers a distinct advantage for patients who are at high-risk for bleeding whilst preserving prostatic tissue for pathology analysis, unlike photoselective vaporization. Further, HoLEP avoids the need for cystotomy, unlike simple open and robotic prostatectomy, by using intravesical morcellation. We report our experience with the first 1000 HoLEP procedures at our institution. Materials and Methods: We performed a retrospective review of all HoLEP procedures performed at our institution from 2013–2021 to capture patient demographics, procedure details,… More >

Michelle K. Li, Orlando Diaz, Jonathan E. Katz

Canadian Journal of Urology, Vol.31, No.2, pp. 11861-11863, 2024

Abstract Standard treatment approaches for localized prostate cancer remain limited to active surveillance, radiotherapy, and radical prostatectomy. We present a case of transition zone prostate cancer that was treated with holmium laser enucleation of the prostate, a procedure that is normally reserved for the management of benign prostatic hyperplasia. More >

Agustín Pérez-Londoño, Alejandro Abello, Boris Gershman, Ruslan Korets

Canadian Journal of Urology, Vol.31, No.2, pp. 11848-11853, 2024

Abstract Holmium laser enucleation of the prostate (HoLEP) is considered a size-independent technique to treat benign prostatic hyperplasia. This safe and effective procedure is increasingly being adopted in urology training programs worldwide, yet limited teaching strategies have been described. Endoscopic handling during HoLEP allows for a simultaneous interaction between the surgeon and trainee, facilitating a guided teaching strategy with increasing difficulty as experience grows. In this article, we describe our stepwise approach for teaching HoLEP as part of a structured surgical training curriculum. We also evaluate the association of our method with intraoperative efficiency parameters and More >

Bruce M. Gao, Seyedamirvala Saadat, Edward J. H. Choi, James Jiang, Akhil K. Das

Canadian Journal of Urology, Vol.31, No.3, pp. 11904-11907, 2024

Abstract Holmium enucleation of the prostate (HoLEP) is a gold standard, size-independent surgical treatment for benign prostatic hyperplasia (BPH) distinguished for its efficacy in tissue removal, shorter catheterization durations, lower transfusion rates, and decreased hospital stays when compared to transurethral resection of the prostate (TURP). The objective of this article is to demonstrate the step-by-step procedure of holmium laser cystolitholapaxy and enucleation of the prostate for BPH, emphasizing a top-down modified two-lobe technique with early apical release which enhances visualization and irrigation flow during the enucleation process. More >

Xiaojuan He¹, Chanyuan Li¹, Shaokang Wang¹, Jingyi Zhu¹, Yabin Zhang^1,*, Zhen Guo², Lihua Wu^3,*

Journal of Polymer Materials, Vol.41, No.4, pp. 263-279, 2024, DOI:10.32604/jpm.2024.055821 - 16 December 2024

Abstract Eye drops are the usual method to treat eye diseases, and gel polymer provides the carrier which could be used for ophthalmic drug delivery. However, the stable and sustained release is the main issue for the ophthalmic drug and is concerned by many researchers. In this study, composite hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA), and N-vinyl-2-pyrrolidone (NVP) used for ophthalmic drug loading and release. According to the results of Fourier transform infrared spectroscopy (FTIR), the disappearance of the C=C bond in hydrogel indicated that the copolymerization reaction between HEMA and NVP was successful. The… More > Graphic Abstract

Andrew M. Higgins¹, Michael J. Wolf², Russell E. N. Becker¹, Khurshid R. Ghani¹

Canadian Journal of Urology, Vol.30, No.3, pp. 11574-11582, 2023

Abstract In North America, ureteroscopy has become the most popular treatment modality for upper urinary tract urinary calculi. Herein we describe our technique for the treatment of renal stones with flexible ureteroscopy and high-power holmium laser lithotripsy. We discuss preoperative planning, intraoperative strategies, and laser settings for a high-frequency dusting technique with the goal to provide optimal patient outcomes. More >

Sayyid Kamran Hussain¹, Ali Haider Khan^2,*, Malek Alrashidi³, Sajid Iqbal⁴, Qazi Mudassar Ilyas⁴, Kamran Shah⁵

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3763-3781, 2023, DOI:10.32604/cmc.2023.041722 - 08 October 2023

Abstract As ocular computer-aided diagnostic (CAD) tools become more widely accessible, many researchers are developing deep learning (DL) methods to aid in ocular disease (OHD) diagnosis. Common eye diseases like cataracts (CATR), glaucoma (GLU), and age-related macular degeneration (AMD) are the focus of this study, which uses DL to examine their identification. Data imbalance and outliers are widespread in fundus images, which can make it difficult to apply many DL algorithms to accomplish this analytical assignment. The creation of effcient and reliable DL algorithms is seen to be the key to further enhancing detection performance. Using… More >