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  • Open Access

    ARTICLE

    MiR-30a-5p alleviates LPS-induced HPMEC injury through regulation of autophagy via Beclin-1

    RAN PAN1,#, JIAYAN MAO2,#, YUELIANG ZHENG3, WEI CHEN2, JUNPING GUO1,*, LIJUN WANG3,*

    BIOCELL, Vol.48, No.3, pp. 431-441, 2024, DOI:10.32604/biocell.2023.046484

    Abstract Background: Sepsis, a type of systemic disease, can impact nearly all organs, tissues and cells. Among them, endothelial cells are amongst the first to be affected and respond to the insult. In this study, we investigated the protective effects of microRNA-30a-5p (miR-30a-5p) on human pulmonary microvascular endothelial cells (HPMECs) treated with lipolysaccharide (LPS). Methods: An in vitro model of sepsis was established in HPMECs with the use of LPS. Transfecting with different tools (mimetic and inhibitor) to modify miR-30a-5p expression. Cell viability, proliferation and apoptosis were detected by the CCK-8 assay, the EdU kit and fluorescence staining, respectively. The autophagy-related… More >

  • Open Access

    REVIEW

    Bacterial endotoxins in periodontal health and diseases

    FARIHA NUSRAT1, MOHAMMAD TARIQUR RAHMAN2, MUHAMMAD MANJURUL KARIM3,*

    BIOCELL, Vol.47, No.1, pp. 81-89, 2023, DOI:10.32604/biocell.2023.024635

    Abstract Bacterial endotoxins are a major concern in periodontal health and diseases owing to their structure and biological activity. With up-to-date knowledge of endotoxins and the recent findings about the influence of endotoxins in dental health, their probable mode of pathogenesis, and standard detection methods, this review analyzes the potential efficacy and benefits of probiotics in combination with conventional and contemporary treatment measures. In the oral cavity, Gram-negative bacteria are documented to predominate in the pulpal lesions with radiolucent areas and in the root canal with pulp necrosis, where they pose an absolute threat by promoting a series of inflammatory reactions.… More >

  • Open Access

    ARTICLE

    BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis

    MEIHUA CHEN1,2, HUIHUI WANG3, XIAOFENG CHEN1,2, YAN CHEN1,2, TIANYING BIAN1,2,*

    BIOCELL, Vol.46, No.10, pp. 2281-2289, 2022, DOI:10.32604/biocell.2022.020697

    Abstract Periodontitis is a frequent chronic inflammatory disorder destroying periodontium. Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor (BETi) and microRNA (miR)-130a in regulating macrophage polarization and pro-inflammatory response. However, little is known about whether apabetalone (a novel BETi) and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization. Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model. After treatment with Porphyromonas gingivalis-derived lipopolysaccharide (Pg LPS) and apabetalone, the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR, western blot, and enzyme-linked immuno sorbent assay… More >

  • Open Access

    REVIEW

    Mechanism of tobacco osmotin gene in plant responses to biotic and abiotic stress tolerance: A brief history

    HAKIM MANGHWAR1,#,*, AMJAD HUSSAIN2,#

    BIOCELL, Vol.46, No.3, pp. 623-632, 2022, DOI:10.32604/biocell.2022.017316

    Abstract Plants are recurrently exposed to myriads of biotic and abiotic stresses leading to several biochemical and physiological variations that cause severe impacts on plant growth and survival. To overcome these challenges, plants activate two primary defense mechanisms, such as structural response (cell wall strengthening and waxy epidermal cuticle development) and metabolic changes, including the synthesis of anti-microbial compounds and proteins, especially the pathogenesis-related (PR) proteins. PR proteins are members of a super large family of defense proteins that exhibit antimicrobial activities. Their over-expression in plants provides tolerance to many abiotic and biotic stresses. PR proteins have been classified into 17… More >

  • Open Access

    ARTICLE

    HSA-MIR-203/MyD88 axis mediates the protective effect of hispidulin on LPS-induced apoptosis in a human renal tubular epithelial line, HK-2

    SICONG WANG1, RUIJIN LIU2, QIUYUAN HAN2, KAIJIANG YU3,*

    BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027

    Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow cytometry. Apoptosis marker proteins were determined by using… More >

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