Naglaa F. Soliman¹, Fatma E. Fadl-Allah², Walid El-Shafai^3,4,*, Mahmoud I. Aly², Maali Alabdulhafith¹, Fathi E. Abd El-Samie¹

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 201-241, 2024, DOI:10.32604/cmc.2024.046757

Abstract The efficient transmission of images, which plays a large role in wireless communication systems, poses a significant challenge in the growth of multimedia technology. High-quality images require well-tuned communication standards. The Single Carrier Frequency Division Multiple Access (SC-FDMA) is adopted for broadband wireless communications, because of its low sensitivity to carrier frequency offsets and low Peak-to-Average Power Ratio (PAPR). Data transmission through open-channel networks requires much concentration on security, reliability, and integrity. The data need a space away from unauthorized access, modification, or deletion. These requirements are to be fulfilled by digital image watermarking and encryption. This paper is mainly… More >

SHAHID KARIM^1,*, ALANOUD NAHER ALGHANMI¹, MAHA JAMAL¹, HUDA ALKREATHY¹, ALAM JAMAL², HIND A. ALKHATABI³, MOHAMMED BAZUHAIR¹, AFTAB AHMAD^4,5

Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988

Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in… More > Graphic Abstract

MARKO SKELIN^1,2,3,*, BRUNA PERKOV-STIPIČIN¹, SANJA VUŠKOVIĆ⁴, MARINA ŠANDRK PLEHAČEK⁵, ANE BAŠIĆ⁶, DAVID ŠARČEVIĆ⁷, MAJA ILIĆ⁸, IVAN KREČAK^2,3,9

Oncology Research, Vol.32, No.5, pp. 807-815, 2024, DOI:10.32604/or.2024.048948

Abstract Background: The European Society for Medical Oncology (ESMO) guidelines are among the most comprehensive and widely used clinical practice guidelines (CPGs) globally. However, the level of scientific evidence supporting ESMO CPG recommendations has not been systematically investigated. This study assessed ESMO CPG levels of evidence (LOE) and grades of recommendations (GOR), as well as their trends over time across various cancer settings. Methods: We manually extracted every recommendation with the Infectious Diseases Society of America (IDSA) classification from each CPG. We examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer types.… More >

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >

YIWEN ZHU¹, LIU YANG¹, YING YU¹, YING XIONG², PING XIAO², XIAO FU², XIN LUO^2,*

Oncology Research, Vol.32, No.5, pp. 899-910, 2024, DOI:10.32604/or.2023.042604

Abstract Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis. Since there is no permanent therapy for this condition, it is necessary to develop a cure. Therefore, this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A (HYSA) in osteosarcoma cell lines (MG63). In this investigational study, MG63 cells were utilized. Microarray experiments, quantitative polymerase chain reaction (qPCR), immunofluorescent staining, extracellular acidification rate (ECAR), oxygen consumption rate (OCR), glucose consumption, lactate production, and ATP levels, proliferation assay, 5-Ethynyl-2′-deoxyuridine (EDU) staining, and Western blot were performed. In MG63… More >

Farhad Mortezapour Shiri^1,*, Ehsan Ahmadi², Mohammadreza Rezaee¹, Thinagaran Perumal¹

Journal on Artificial Intelligence, Vol.6, pp. 85-103, 2024, DOI:10.32604/jai.2024.048911

Abstract Automatic detection of student engagement levels from videos, which is a spatio-temporal classification problem is crucial for enhancing the quality of online education. This paper addresses this challenge by proposing four novel hybrid end-to-end deep learning models designed for the automatic detection of student engagement levels in e-learning videos. The evaluation of these models utilizes the DAiSEE dataset, a public repository capturing student affective states in e-learning scenarios. The initial model integrates EfficientNetV2-L with Gated Recurrent Unit (GRU) and attains an accuracy of 61.45%. Subsequently, the second model combines EfficientNetV2-L with bidirectional GRU (Bi-GRU), yielding an accuracy of 61.56%. The… More >

Yiyi Cen^1,3, Wenzheng Jia², Wen Dai^3,*, Chun Wang⁴, He Wu¹

Revue Internationale de Géomatique, Vol.33, pp. 93-109, 2024, DOI:10.32604/rig.2024.050273

Abstract Color, as a significant element of village landscapes, serves various functions such as enhancing aesthetic appeal and attractiveness, conveying emotions and cultural values. To explore the three-dimensional spatial characteristics of color landscapes in beautiful villages, this study conducted a comparative experiment involving eight provincial-level beautiful villages and eight ordinary villages in Jinzhai County. Landscape pattern indices were used to analyze the color landscape patterns on the facades of these villages, complemented by a quantitative analysis of color attributes using the Munsell color system. The results indicate that (1) Natural landscape colors in beautiful villages are primarily concentrated in the yellow-red… More >

Xukai Ren^1,2,*, Huanwei Yu², Xianfeng Chen², Yantong Tang², Guobiao Wang^1,*, Xiyong Du²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 647-663, 2024, DOI:10.32604/cmes.2024.048782

Abstract Stirred reactors are key equipment in production, and unpredictable failures will result in significant economic losses and safety issues. Therefore, it is necessary to monitor its health state. To achieve this goal, in this study, five states of the stirred reactor were firstly preset: normal, shaft bending, blade eccentricity, bearing wear, and bolt looseness. Vibration signals along x, y and z axes were collected and analyzed in both the time domain and frequency domain. Secondly, 93 statistical features were extracted and evaluated by ReliefF, Maximal Information Coefficient (MIC) and XGBoost. The above evaluation results were then fused by D-S evidence… More >

Chengbao Hu^1,2,3, Shilin Gong^4,*, Bin Chen^1,2,3, Zhongling Zong⁴, Xingwang Bao⁵, Xiaojian Ru⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 997-1015, 2024, DOI:10.32604/cmes.2024.048640

Abstract Strain localization frequently occurs in cohesive materials with friction (e.g., composites, soils, rocks) and is widely recognized as a fundamental cause of progressive structural failure. Nonetheless, achieving high-fidelity simulation for this issue, particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones, remains significantly constrained. In response, this study introduces an integrated algorithm within the finite element framework, merging a coupled cohesive zone model (CZM) with the nonlinear augmented finite element method (N-AFEM). The coupled CZM comprehensively describes tension-compression and compression-shear failure behaviors in cohesive, frictional materials, while the N-AFEM allows nonlinear coupled intra-element discontinuities without necessitating extra nodes or… More >

Xianwei Jiang¹, Yanqiong Zhang^1,*, Juan Lei¹, Yudong Zhang^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1-40, 2024, DOI:10.32604/cmes.2024.047649

Abstract Research on Chinese Sign Language (CSL) provides convenience and support for individuals with hearing impairments to communicate and integrate into society. This article reviews the relevant literature on Chinese Sign Language Recognition (CSLR) in the past 20 years. Hidden Markov Models (HMM), Support Vector Machines (SVM), and Dynamic Time Warping (DTW) were found to be the most commonly employed technologies among traditional identification methods. Benefiting from the rapid development of computer vision and artificial intelligence technology, Convolutional Neural Networks (CNN), 3D-CNN, YOLO, Capsule Network (CapsNet) and various deep neural networks have sprung up. Deep Neural Networks (DNNs) and their derived… More >