Lei Jiang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.2, pp. 47-48, 2011, DOI:10.3970/icces.2011.019.047

Abstract Ocean resources, for which the modern military and economy are competing, are the material sources for sustainable development. In order to keep our own rights in the competition of international resources, the project to develop a deep-sea HOV was started.
In this paper different requirements of O2 concentration in the closed space of various underwater vehicles such as submarine and HOV is introduced. Based on that, from the aspects of power, space size, influence to the environment and O2 concentration the particular demands for delivering O2 are analyzed. Several O2 delivering methods in the closed space such as the… More >

R.H. Moore¹, S. Saigal²

CMES-Computer Modeling in Engineering & Sciences, Vol.7, No.3, pp. 283-292, 2005, DOI:10.3970/cmes.2005.007.283

Abstract An efficient method for treating slivers and other poorly shaped elements in finite element solutions is presented. A major difficulty for finite element analyses arises from the creation of slivers in automated mesh generation. Sliver shaped elements can degrade the accuracy of a solution and are difficult to remove from a mesh. The proposed method treats slivers by first merging them with neighboring elements to form polyhedra and next subdividing the polyhedra into well-shaped tetrahedral elements. The method does not require the cumbersome and expensive operations of addition or rearrangement of nodes. The validity and accuracy of the present method… More >

Yan Cai^1,1, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 59-81, 2017, DOI:10.3970/mcb.2017.014.057

Abstract To investigate the dynamic changes of solid tumor and neo-vasculature in response to chemotherapeutic agent, we proposed a multi-discipline three-dimensional mathematical model by coupling tumor growth, angiogenesis, vessel remodelling, microcirculation and drug delivery. The tumor growth is described by the cell automaton model, in which three cell phenotypes (proliferating cell, quiescent cell and necrotic cell) are assumed to reflect the dynamics of tumor progress. A 3D tree-like architecture network with different orders for vessel diameter is generated as pre-existing vasculature in host tissue. The chemical substances including oxygen, vascular endothelial growth factor, extra-cellular matrix and matrix degradation enzymes are calculated… More >

Hangjun Zhou^1,2,*, Guang Sun¹, Sha Fu¹, Wangdong Jiang¹, Tingting Xie³, Danqing Duan¹

CMC-Computers, Materials & Continua, Vol.56, No.1, pp. 73-89, 2018, DOI: 10.3970/cmc.2018.02411

Abstract In the large-scale Distributed Virtual Environment (DVE) multimedia systems, one of key challenges is to distributedly preserve causal order delivery of messages in real time. Most of the existing causal order control approaches with real-time constraints use vector time as causal control information which is closely coupled with system scales. As the scale expands, each message is attached a large amount of control information that introduces too much network transmission overhead to maintain the real-time causal order delivery. In this article, a novel Lightweight Real-Time Causal Order (LRTCO) algorithm is proposed for large-scale DVE multimedia systems. LRTCO predicts and compares… More >

Xinyue Liu¹, Yunqiao Liu¹, Xiaobo Gong^1,*, Huaxiong Huang²

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 281-300, 2018, DOI: 10.31614/cmes.2018.04989

Abstract In this work, a three-dimensional axisymmetric model with nanoparticle, receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery. The minimization of the system energy function was carried out numerically, and the deformations of nanoparticle, receptor-ligand bonds and cell membrane were predicted. Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process, and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage. Our results suggest that, in addition to the energy requirement,… More >

Eduardo M. B. Campello^1,2, Tarek I. Zohdi³

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 221-245, 2014, DOI:10.3970/cmes.2014.098.221

Abstract This work deals with the bombardment of a stream of particles possessing varying mean particle size, velocity and aspect ratio into a cell that has fixed (known) compliance characteristics. The particles are intended to penetrate the cell membrane causing zero or minimum damage and deliver foreign substances (which are attached to their surfaces) to the interior of the cell. We adopt a particle-based (discrete element method) computational model that has been recently developed by the authors to describe both the incoming stream of particles and the cell membrane. By means of parametric numerical simulations, treating the stream’s mean particle size,… More >

K.W. Luczynski¹, A. Dejaco¹, O. Lahayne¹, J. Jaroszewicz², W.Swieszkowski², C. Hellmich¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 505-529, 2012, DOI:10.3970/cmes.2012.087.505

Abstract A 71 volume-% macroporous tissue engineering scaffold made of poly-l-lactide (PLLA) with 10 mass-% of pseudo-spherical tri-calcium phosphate (TCP) inclusions (exhibiting diameters in the range of several nanometers) was microCT-scanned. The corresponding stack of images was converted into regular Finite Element (FE) models consisting of around 100,000 to 1,000,000 finite elements. Therefore, the attenuation-related, voxel-specific grey values were converted into TCP-contents, and the latter, together with nanoindentation tests,entered a homogenization scheme of the Mori-Tanaka type, as to deliver voxel-specific (and hence, finite element-specific) elastic properties. These FE models were uniaxially loaded, giving access to the macroscopic Young's modulus of the… More >

J.A. Ferreira^2,3, P. de Oliveira², P. Silva⁴, J.N. Murta⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.71, No.1, pp. 1-14, 2011, DOI:10.3970/cmes.2011.071.001

Abstract Mathematical models to describe drug concentration profiles of topically administered drug in the anterior chamber aqueous humor have been proposed by several authors. The aim of this paper is to present a mathematical model to predict the drug concentration in the anterior chamber when a therapeutical contact lens with the drug entrapped in nanoparticles is used. More >

J.A.Ferreira^2,3, P. Oliveira¹, P.M. Silva⁴, A. Carreira^5,3, J.N. Murta⁶

CMES-Computer Modeling in Engineering & Sciences, Vol.60, No.2, pp. 151-180, 2010, DOI:10.3970/cmes.2010.060.151

Abstract This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. More >