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  • Open Access


    MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma

    Minhua Wu*1, Xubin Deng†1, Yu Zhong‡1, Li Hu*, Xiujuan Zhang§, Yanqin Liang*, Xiaofang Li, Xiaoxia Ye*

    Oncology Research, Vol.28, No.3, pp. 299-309, 2020, DOI:10.3727/096504020X15796890809840

    Abstract MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. But the expression and function of MafF in hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. We found that MafF decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. Bioinformatics analysis and luciferase assay identified MafF as a direct target of miR-224-5p. RNA pull-down assay demonstrated that circular RNA circ-ITCH… More >

  • Open Access


    Exocytosis, endocytosis and recycling of secretory vesicles in neuroendocrine cells, and its regulation by cortical actin


    BIOCELL, Vol.46, No.8, pp. 1867-1873, 2022, DOI:10.32604/biocell.2022.019086

    Abstract The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to stimuli. This dynamic network of cortical filaments, together with motor myosin partners, adjusts the plasmalemma tension, organizes membrane protein microdomains, remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis, endocytosis and recycling of secretory vesicles. In this review, we discuss how these mechanisms work in secretory cells. More >

  • Open Access


    Adenosine A1 receptor activation inhibits histamine release in gastric enterochromaffin-like cells

    Rafael Martins de OLIVEIRA, Carolina Bernardi STEFANI, Angélica Aparecida Antoniellis SILVEIRA, Marcelo Lima RIBEIRO, José PEDRAZZOLI Jr., Alessandra GAMBERO*

    BIOCELL, Vol.39, No.2-3, pp. 5-8, 2015, DOI:10.32604/biocell.2015.39.005

    Abstract Adenosine acts as a gastroprotective factor decreasing inflammation and reducing gastric acid secretion. Quantitative RT-PCR was used to determine the expression of the adenosine receptor genes (A1AR, A2AAR, A2BAR and A3AR) and that of the gastrin receptor B gene (CCKBR) in isolated, short-term cultured enterochromaffin-like (ECL) cells. Both the A1AR and the CCKBR genes were expressed at a level higher than the other genes. Also, the effect of 2-chloroadenosine, a stable agonist of A1 and A2A receptors, was explored on ECL cells, with a resulting inhibition of both basal and gastrin-stimulated histamine release. Also, dipropylcyclopentylxanthine (DPCPX), a selective A1 antagonist,… More >

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