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  • Open Access


    Regularised Layerwise Weight Norm Based Skin Lesion Features Extraction and Classification

    S. Gopikha*, M. Balamurugan

    Computer Systems Science and Engineering, Vol.44, No.3, pp. 2727-2742, 2023, DOI:10.32604/csse.2023.028609

    Abstract Melanoma is the most lethal malignant tumour, and its prevalence is increasing. Early detection and diagnosis of skin cancer can alert patients to manage precautions and dramatically improve the lives of people. Recently, deep learning has grown increasingly popular in the extraction and categorization of skin cancer features for effective prediction. A deep learning model learns and co-adapts representations and features from training data to the point where it fails to perform well on test data. As a result, overfitting and poor performance occur. To deal with this issue, we proposed a novel Consecutive Layerwise weight Constraint MaxNorm model (CLCM-net)… More >

  • Open Access


    Hybrid Color Texture Features Classification Through ANN for Melanoma

    Saleem Mustafa1, Arfan Jaffar1, Muhammad Waseem Iqbal2,*, Asma Abubakar2, Abdullah S. Alshahrani3, Ahmed Alghamdi4

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2205-2218, 2023, DOI:10.32604/iasc.2023.029549

    Abstract Melanoma is of the lethal and rare types of skin cancer. It is curable at an initial stage and the patient can survive easily. It is very difficult to screen all skin lesion patients due to costly treatment. Clinicians are requiring a correct method for the right treatment for dermoscopic clinical features such as lesion borders, pigment networks, and the color of melanoma. These challenges are required an automated system to classify the clinical features of melanoma and non-melanoma disease. The trained clinicians can overcome the issues such as low contrast, lesions varying in size, color, and the existence of… More >

  • Open Access


    Upregulated lncRNA CASC2 May Inhibit Malignant Melanoma Development Through Regulating miR-18a-5p/RUNX1

    Yankun Zhang*, Wei Qian*, Feng Feng, Qian Cao*, Yanqi Li*, Ying Hou*, Luyang Zhang*, Jufeng Fan*

    Oncology Research, Vol.27, No.3, pp. 371-377, 2019, DOI:10.3727/096504018X15178740729367

    Abstract This study aimed to investigate the effect and underlying mechanism of lncRNA CASC2 in malignant melanoma (MM). Expression of CASC2 in MM tissues and cells was detected. A375 cells were transfected with pc-CASC2, si-CASC2, miR-18a-5p inhibitor, or corresponding controls, and then cell proliferation, migration, and invasion were detected using MTT assay, colony formation assay, and Transwell analysis, respectively. The relationship of miR-18a-5p and CASC2 or RUNX1 was detected by luciferase reporter assay. The levels of CASC2 and RUNX1 were significantly reduced in MM tissues compared with normal skin tissues or cells, while the miR-18a-5p level was obviously increased (all p<0.01).… More >

  • Open Access


    miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB

    Xiyan Sun*1, Chao Zhang†1, Yang Cao, Erbiao Liu*

    Oncology Research, Vol.27, No.3, pp. 317-323, 2019, DOI:10.3727/096504018X15228863026239

    Abstract miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between… More >

  • Open Access


    Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study

    Xiaoting Wei, Lili Mao, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Yan Kong, Jie Dai, Xuan Wang, Siming Li, Bixia Tang, Bin Lian, Xieqiao Yan, Xue Bai, Li Zhou, Jun Guo, Lu Si

    Oncology Research, Vol.27, No.4, pp. 495-501, 2019, DOI:10.3727/096504018X15331163433914

    Abstract Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment is a promising approach in treating advanced melanoma patients harboring c-Kit mutations or amplifications. We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring c-Kit mutations or amplifications. These patients were treated with imatinib at a dose of 400 mg/day continuously unless intolerable toxicities or disease progression occurred. Endpoints for exploration included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease of control rate (DCR). The median OS and PFS of all patients were 13.1 and 4.2 months,… More >

  • Open Access


    Cylindromatosis Is Required for Survival of a Subset of Melanoma

    Ting La*†, Lei Jin*‡, Xiao Ying Liu*, Ze Hua Song*, Margaret Farrelly, Yu Chen Feng, Xu Guang Yan, Yuan Yuan Zhang*,† Rick F. Thorne*,*§ Xu Dong Zhang*†, Liu Teng*

    Oncology Research, Vol.28, No.4, pp. 385-398, 2020, DOI:10.3727/096504020X15861709922491

    Abstract The deubiquitinase cylindromatosis (CYLD) functions as a tumor suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although short hairpin RNA (shRNA) knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in a fraction of melanoma cell… More >

  • Open Access


    uPAR Controls Vasculogenic Mimicry Ability Expressed by Drug-Resistant Melanoma Cells

    Elena Andreucci*1, Anna Laurenzana*, Silvia Peppicelli*, Alessio Biagioni*, Francesca Margheri*, Jessica Ruzzolini*, Francesca Bianchini*, Gabriella Fibbi*, Mario Del Rosso*†, Chiara Nediani*, Simona Serratì, Livia Fucci§, Michele Guida, Lido Calorini*†1

    Oncology Research, Vol.28, No.9, pp. 873-884, 2020, DOI:10.3727/096504021X16273798026651

    Abstract Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows adaptation of melanoma cells to different hostile conditions and guarantees tumor survival and disease progression, including aggressive features such as drug resistance. Indeed, almost 50% of melanoma rapidly develop resistance to the BRAFV600E inhibitor vemurafenib, with fast tumor dissemination, a devastating consequence for patients’ outcomes. Vasculogenic mimicry (VM), the ability of cancer cells to organize themselves in perfused vascular-like channels, might sustain tumor spread by providing vemurafenibresistant cancer cells with supplementary ways to enter into circulation and disseminate. Thus, this… More >

  • Open Access


    Retraction notice to “MicroRNA-539 Inhibits the Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Twist-Related Protein 1-Mediated Modulation of Melanoma-Associated Antigen A4” [Oncology Research 26(4) (2018) 529-536]

    Zhili Cao*1, Xiang Zheng†1, Lei Cao*, Naixin Liang*

    Oncology Research, Vol.28, No.7-8, pp. 831-831, 2020, DOI:10.3727/096504020X16231418632584

    Abstract This article has no abstract. More >

  • Open Access


    A Primary Sacral Melanoma of Unknown Origin: A Case Report

    Ismail Bozkurt1,*, Baris Yasar1, Mehmet Baran Uslu2, Nazan Bozdogan3

    Oncologie, Vol.24, No.1, pp. 163-171, 2022, DOI:10.32604/oncologie.2022.019263

    Abstract Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4–5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant… More >

  • Open Access


    Image Masking and Enhancement System for Melanoma Early Stage Detection

    Fikret Yalcinkaya*, Ali Erbas

    Intelligent Automation & Soft Computing, Vol.33, No.3, pp. 1961-1977, 2022, DOI:10.32604/iasc.2022.024961

    Abstract Early stage melanoma detection (ESMD) is crucial as late detection kills. Computer aided diagnosis systems (CADS) integrated with high level algorithms are major tools capable of ESMD with high degree of accuracy, specificity, and sensitivity. CADS use the image and the information within the pixels of the image. Pixels’ characteristics and orientations determine the colour and shapes of the images as the pixels and associated environment are closely interrelated with the lesion. CADS integrated with Convolutional Neural Networks (CNN) specifically play a major role for ESMD with high degree of accuracy. The proposed system has two steps to produce high… More >

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