Juan Yang^1,2,#, Jiahui Zhang^3,#, Le Zhang^1,2,*, Zhenshan Yang^4,*

BIOCELL, Vol.49, No.3, pp. 399-417, 2025, DOI:10.32604/biocell.2025.059908 - 01 April 2025

Abstract With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to More >

JINGWEI JIANG^1,2, BO JIA³, CHUAN WANG³, CHEN FANG¹, YUGUI LI¹, GUOXING LING¹, BAOSHI ZHENG^1,*, CHENG LUO^1,*

BIOCELL, Vol.49, No.1, pp. 61-78, 2025, DOI:10.32604/biocell.2024.056981 - 24 January 2025

Abstract The role and regulatory mechanisms of macrophage polarization in cardiac transplantation have gained significant attention. Macrophages can polarize into either the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype in response to environmental cues. M1 macrophages facilitate transplant rejection by releasing inflammatory mediators and activating T cells, whereas M2 macrophages support graft survival by secreting anti-inflammatory factors and promoting tissue repair. Mitochondrial quality control regulation plays a crucial role in macrophage polarization, which may influence graft survival and immune responses. This review provides an overview of the current understanding of mitochondrial quality control-regulated macrophage polarization in cardiac More >