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  • Open Access


    Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the uterine cervix: An analysis of 6 cases with distinctive clinicopathological features


    BIOCELL, Vol.45, No.5, pp. 1313-1319, 2021, DOI:10.32604/biocell.2021.015923

    Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6 ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including… More >

  • Open Access


    Combined Surgical Treatment of Atherosclerotic Coronary Artery Disease and Moderate Aortic Valve Stenosis in Patient with Concomitant Lipton’s R-III Type of Single Coronary Artery Anomaly

    Milica Karadzic Kocica1, Hristina Ugrinovic1, Dejan Lazovic2, Nemanja Karamarkovic2, Milos Grujic2, Borivoje Lukic3, Oliver Radmili3, Vladimir Cvetic3, Mladen Kocica2,*

    Congenital Heart Disease, Vol.16, No.6, pp. 647-653, 2021, DOI:10.32604/CHD.2021.016923

    Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare More >

  • Open Access


    Multi-Layer Reconstruction Errors Autoencoding and Density Estimate for Network Anomaly Detection

    Ruikun Li1,*, Yun Li2, Wen He1,3, Lirong Chen1, Jianchao Luo1

    CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.1, pp. 381-398, 2021, DOI:10.32604/cmes.2021.016264

    Abstract Anomaly detection is an important method for intrusion detection. In recent years, unsupervised methods have been widely researched because they do not require labeling. For example, a nonlinear autoencoder can use reconstruction errors to attain the discrimination threshold. This method is not effective when the model complexity is high or the data contains noise. The method for detecting the density of compressed features in a hidden layer can be used to reduce the influence of noise on the selection of the threshold because the density of abnormal data in hidden layers is smaller than normal… More >

  • Open Access


    Mir-612 Inhibits Proliferation and Invasion of Urothelial Carcinoma of Bladder Cells through Activating Hippo Pathway via Targeting PMEPA1

    Peng Wang, Haiyang Zhang, Zilian Cui, Xunbo Jin*, Dong Zhang*

    Oncologie, Vol.23, No.2, pp. 259-268, 2021, DOI:10.32604/Oncologie.2021.015503

    Abstract Urothelial carcinoma of bladder (UCB) is a common urological malignancy in the world, but its progression mechanism remains unclear. MiR-612 was found as an anti-tumor factor in multiple types of cancer, while few studies have revealed its functions in UCB cells. Based on this, UCB cells such as HTB-9 and HTB-4, and normal urothelial of bladder cells such as SV-Huc1, were used as subjects in this study. Western blot, qRTPCR, CCK-8 assay and transwell assay were used to assess functions of miR-612 in UCB cells. The database, miRWalk, was used to search for potential targets… More >

  • Open Access


    HBx Downregulates miR-422a Expression via Activation of FOXG1/Q1/E1 in HepG2 Cells

    Xiaofan Deng1,2, Yamei Yang2,3, Xianfeng Gan2,3, Gang Wu2,3,*

    Oncologie, Vol.23, No.2, pp. 251-258, 2021, DOI:10.32604/Oncologie.2021.016900

    Abstract microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid tumors including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) downregulated expression of miR-422a in HCC cell line HepG2 in vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate miR-422a expression, and this prompted us to determine whether HBx suppresses miR-422a expression via activation of FOXG1/Q1/E1. The relationship between FOXG1/Q1/E1 and miR-422a in HepG2 cells stably expressing HBx was assessed with qRT-PCR. The correlation between HBx and FOXG1/Q1/E1 was determined with qRT-PCR More >

  • Open Access


    A Nomogram for Predicting Lateral Lymph Node Metastasis in Cases of Papillary Thyroid Micro-Carcinoma with Suspected Lymph Node Metastasis

    Yu Xiao1, Peng Zhou2, Yizi Zheng1, Chang Zheng1, Guowen Liu1, Weixiang Liu3,*

    Oncologie, Vol.23, No.2, pp. 219-228, 2021, DOI:10.32604/Oncologie.2021.016480

    Abstract The elevation for lateral lymph node metastasis (LLNM) plays an important role in therapeutic decision-making for thyroid carcinoma. A reliable forecasting model for LLNM in patients with papillary thyroid micro-carcinoma (PTMC) is needed, using clinicopathological characteristics. A total of 576 PTMC patients with suspicious lateral cervical lymph node (II, III, IV or V region) metastasis and known clinicopathological variables were randomly collected at Shenzhen Second People’s Hospital. Cervical lymph node status of every patient was assessed by ultrasonography (US). The patients in this cohort study underwent thyroidectomy and lateral neck lymph node dissection. Univariate analysis… More >

  • Open Access


    Capacity and Fairness Maximization-Based Resource Allocation for Downlink NOMA Networks

    Mohammed Abd-Elnaby*

    CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 521-537, 2021, DOI:10.32604/cmc.2021.018351

    Abstract Non-orthogonal multiple access (NOMA) is one of the leading technologies for 5G communication. User pairing (UP) and power allocation (PA) are the key controlling mechanisms for the optimization of the performance of NOMA systems. This paper presents a novel UP and PA (UPPA) technique for capacity and fairness maximization in NOMA called (CFM-UPPA). The impact of the power allocation coefficient and the ratio between the channel gains of the paired users on the sum-rate capacity and the fairness in NOMA is firstly investigated. Then, based on this investigation, the PA and UP algorithms of the… More >

  • Open Access


    PAPR Reduction in NOMA by Using Hybrid Algorithms

    Mohit Kumar Sharma, Arun Kumar*

    CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 1391-1406, 2021, DOI:10.32604/cmc.2021.017666

    Abstract Non-orthogonal multiple access (NOMA) is gaining considerable attention due to its features, such as low out-of-band radiation, signal detection capability, high spectrum gain, fast data rate, and massive D2D connectivity. It may be considered for 5G networks. However, the high peak-to-average power ratio (PAPR) is viewed as a significant disadvantage of a NOMA waveform, and it weakens the quality of signals and the throughput of the scheme. In this article, we introduce a modified NOMA system by employing a block of wavelet transform, an alternative to FFT (Fast Fourier transform). The modified system combines the More >

  • Open Access


    Mining Bytecode Features of Smart Contracts to Detect Ponzi Scheme on Blockchain

    Xiajiong Shen1,3, Shuaimin Jiang2,3, Lei Zhang1,2,3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.3, pp. 1069-1085, 2021, DOI:10.32604/cmes.2021.015736

    Abstract The emergence of smart contracts has increased the attention of industry and academia to blockchain technology, which is tamper-proofing, decentralized, autonomous, and enables decentralized applications to operate in untrustworthy environments. However, these features of this technology are also easily exploited by unscrupulous individuals, a typical example of which is the Ponzi scheme in Ethereum. The negative effect of unscrupulous individuals writing Ponzi scheme-type smart contracts in Ethereum and then using these contracts to scam large amounts of money has been significant. To solve this problem, we propose a detection model for detecting Ponzi schemes in… More >

  • Open Access


    Biomedical overview of melanin. 1. Updating melanin biology and chemistry, physico-chemical properties, melanoma tumors, and photothermal therapy


    BIOCELL, Vol.45, No.4, pp. 849-862, 2021, DOI:10.32604/biocell.2021.015900

    Abstract Melanins (eumelanin, pheomelanin, and allomelanin) represent a very, if not the most, important group of biological pigments. Their biological roles are multiple, from photoprotection to antioxidant activity, heavy metal disposal or the myriad uses of color in organisms across all Phyla. In the first part of this review, eumelanin biology and some chemical aspects will be presented, as well as key physico-chemical features that make this biological pigment so interesting. The principal characteristics of the melanocyte, the melanin-synthesizing cell in mammals, will also be introduced. Transformed melanocytes are the cause of one of the most More >

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