JIAHENG WEI¹, LIANGMING ZHU^2,*

Oncology Research, Vol.33, No.4, pp. 863-872, 2025, DOI:10.32604/or.2024.054201 - 19 March 2025

Abstract Lung cancer is one of the main causes of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most prevalent histological subtype of lung cancer. Glutathione peroxidase 4 (GPX4) is a crucial antioxidant enzyme that plays a role in regulating ferroptosis. It is also involved in a wide variety of biological processes, such as tumor cell growth invasion, migration, and resistance to drugs. This study comprehensively examined the role of GPX4 in NSCLC and investigated the clinical feasibility of targeting GPX4 for NSCLC treatment. We discovered that GPX4 influences the progression of NSCLC More >

JIYUN PANG^1,2,#, WEIGANG XIU^1,#, YUEYUN CHEN⁴, WENJING LIAO^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.33, No.4, pp. 895-904, 2025, DOI:10.32604/or.2024.053363 - 19 March 2025

Abstract Background: Non-small cell lung cancer (NSCLC) is often accompanied by brain metastasis (BM), and the prognosis of patients with BM is poor. This study assesses the prognostic impact of BM in NSCLC patients with epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively evaluated 692 advanced NSCLC patients with EGFR mutations treated with tyrosine kinase inhibitors (TKIs) at West China Hospital from 2015 to 2019. The overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), disease control rate (DCR), and clinical parameters of the BM and non-BM groups were compared. Univariable and multivariable… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 733-733, 2025, DOI:10.32604/or.2024.056906 - 28 February 2025

Abstract This article has no abstract. More >

TAO SUN^1,2, QINGHUA SONG³, HUA LIU^1,*

Oncology Research, Vol.33, No.1, pp. 133-148, 2025, DOI:10.32604/or.2024.054141 - 20 December 2024

Abstract Background: Lung cancer is a life-threatening disease that occurs worldwide, but is especially common in China. The crucial role of the tumour microenvironment (TME) in non-small cell lung cancer (NSCLC) has attracted recent attention. Cancer-associated fibroblasts (CAFs) are the main factors that contribute to the TME function, and CAF exosomes are closely linked to NSCLC. Methods: The expression levels of miR-3124-5p and Toll-interacting protein (TOLLIP) were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot detection. Fibroblasts were isolated and identified from clinical NSCLC tissues. Transmission electron microscopy and Western Blot were used to identify exosomes… More >

GENGYUN SUN^1,*, YIPING ZHENG^1,2, JIANFENG CAI², JIE GAO², LIE DONG², XIANGBIN ZHANG², YINGHUI HUANG^2,*

Oncology Research, Vol.33, No.1, pp. 171-184, 2025, DOI:10.32604/or.2024.047626 - 20 December 2024

Abstract Background: Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. Methods: LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the… More > Graphic Abstract

Man Liu¹, Zhuoheng Lv^1,#, Hongjing Wang^2,*, Lu Liu^1,*

Psycho-Oncologie, Vol.18, No.4, pp. 305-316, 2024, DOI:10.32604/po.2024.054098 - 04 December 2024

Abstract Objective: Non-small cell lung cancer (NSCLC) patients often experience significant fear of recurrence. To facilitate precise identification and appropriate management of this fear, this study aimed to compare the efficacy and accuracy of a Backpropagation Neural Network (BPNN) against logistic regression in modeling fear of cancer recurrence prediction. Methods: Data from 596 NSCLC patients, collected between September 2023 and December 2023 at the Cancer Hospital of the Chinese Academy of Medical Sciences, were analyzed. Nine clinically and statistically significant variables, identified via univariate logistic regression, were inputted into both BPNN and logistic regression models developed… More >

Lu Liu^#, Zhuoheng Lv^#, Yousheng Mao, Yan Liu^*, Man Liu^*

Psycho-Oncologie, Vol.18, No.4, pp. 317-328, 2024, DOI:10.32604/po.2024.053678 - 04 December 2024

Abstract Background: Lung cancer, one of the most prevalent and deadly malignancies worldwide, not only poses a significant physical burden but also a profound psychological challenge to patients. Among these psychological challenges, the fear of recurrence stands out as a particularly distressing issue. This fear, often rooted in the patients’ past experiences with the disease and its treatment, can significantly impact their quality of life, mental health, and even compliance with follow-up care. Moreover, this fear can be exacerbated by the lack of understanding and support from healthcare professionals and family members, further isolating patients and… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1813-1813, 2024, DOI:10.32604/or.2024.056888 - 16 October 2024

Abstract This article has no abstract. More >

SHAIL RAKESH MODI, TERRICK ANDEY^*

Oncology Research, Vol.32, No.11, pp. 1709-1721, 2024, DOI:10.32604/or.2024.053972 - 16 October 2024

Abstract Objectives: EGFR tyrosine kinase inhibitor (EGFR-TKI) therapies such as erlotinib and gefitinib are approved for the treatment of non-small cell lung cancer (NSCLC). However, the high incidence of acquired resistance to these EGFR-TKIs may preclude their effectiveness. Piperlongumine (PPL), an extract from the long pepper fruit (Piper longum), has been shown to possess anticancer properties. The purpose of the study was to investigate piperlongumine as an anticancer agent and to study a combination treatment approach with EGFR-TKIs against lung cancer cells. Methods: Anticancer efficacy of PPL, erlotinib (ERL), gefitinib (GEF), and cisplatin (CIS) were investigated in… More >

JINNI MA^#, MEILIN ZHOU^#, XIN XU, XINYAO GAO, HAIXIA WANG, JINHUA SHEN, LU XUE^*

BIOCELL, Vol.48, No.2, pp. 239-252, 2024, DOI:10.32604/biocell.2023.045076 - 23 February 2024

Abstract Background: Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. Methods: Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. Results: TMA results showed that PLAC8 played complex More >