Pietro Tralongo1,#,*, Mariagiovanna Ballato1,#, Valeria Zuccalà2, Vincenzo Fiorentino2, Walter Giordano1, Giovanna Casili3, Fabiola Bellinghieri4, Gerardo Caruso5, Filippo Flavio Angileri5, Guido Fadda2, Maurizio Martini2,§, Maria Caffo5,§
Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.076088
- 21 May 2026
Abstract Glioblastoma (GB) is the most common primary malignant brain tumor of adulthood, and despite optimal safe resection and chemoradiation, it is still lethal. Neuroscience of cancer has shown that neuronal activities, as well as neurotransmitters, play an active role in the glioma microenvironment. This article aims to integrate the existing literature on the role of neurotransmitters and their receptors in glioblastoma, as well as other gliomas, highlighting areas of therapeutic intervention in the neuron-tumor interface. We will describe the neuro–glioma interface, including functional neuron–glioma synapses and activity-dependent tumor growth. We will also discuss major neurotransmitter… More >
Graphic Abstract