Sayyid Kamran Hussain¹, Ali Haider Khan^2,*, Malek Alrashidi³, Sajid Iqbal⁴, Qazi Mudassar Ilyas⁴, Kamran Shah⁵

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3763-3781, 2023, DOI:10.32604/cmc.2023.041722 - 08 October 2023

Abstract As ocular computer-aided diagnostic (CAD) tools become more widely accessible, many researchers are developing deep learning (DL) methods to aid in ocular disease (OHD) diagnosis. Common eye diseases like cataracts (CATR), glaucoma (GLU), and age-related macular degeneration (AMD) are the focus of this study, which uses DL to examine their identification. Data imbalance and outliers are widespread in fundus images, which can make it difficult to apply many DL algorithms to accomplish this analytical assignment. The creation of effcient and reliable DL algorithms is seen to be the key to further enhancing detection performance. Using… More >

LINGYAN LV^1,2,#, JING ZHAO^1,2,#, XUAN WANG^1,2, LIUYAN XU^1,2, YINGYI FAN², CHUNHUI WANG³, HONGQIAO FAN^4,5,*, XIAOHUA PEI^5,*

BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742 - 28 September 2023

Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions… More >

SHIMING YE^1,2,#, YUFENG ZHANG^3,#, TING LIU⁴, CONG WANG³, ZHENG YAN⁵, WANDONG SHE^2,*, HAIBING HUA^4,*

BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333 - 28 September 2023

Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A… More >

CHENHAO SHI¹, MAOHONG HUA², GUANHUA XU^3,*

BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381 - 19 May 2023

Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify… More >

Mahmoud A. Abdelghany^1,4, Mohamed Fathy Abo Sree², Arpan Desai³, Ahmed A. Ibrahim^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.2, pp. 1999-2015, 2023, DOI:10.32604/cmes.2023.023643 - 06 February 2023

Abstract A 4-port multiple-input multiple-output (MIMO) antenna exhibiting low mutual coupling and UWB performance is developed. The octagonal-shaped four-antenna elements are connected with a 50 Ω microstrip feed line that is arranged rotationally to achieve the orthogonal polarization for improving the MIMO system performance. The antenna has a wideband impedance bandwidth of 7.5 GHz with S₁₁ < −10 dB from (103.44%) 3.5–11 GHz and inter-element isolation higher than 20 dB. Antenna validation is carried out by verifying the simulated and measured results after fabricating the antenna. The results in the form of omnidirectional radiation patterns, peak gain (≥4 dBi), and Envelope Correlation Coefficient (ECC) (≤0.01) More > Graphic Abstract

YAO LU^1,2,*, QIUYUE WANG¹, CAIHUI ZHANG¹

BIOCELL, Vol.47, No.2, pp. 393-400, 2023, DOI:10.32604/biocell.2023.024944 - 18 November 2022

Abstract Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization… More >

Xiaoting Liang¹, Fang Liu^1,*, Linqi Wang¹, Baoying Zheng¹, Yiyuan Sun²

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 469-488, 2023, DOI:10.32604/cmc.2023.029641 - 22 September 2022

Abstract Driven by the visions of the Internet of Things (IoT), Artificial Intelligence (AI), and 5G communications, the Internet of Cultural Things (IoCT) realize the comprehensive interconnection among cultural products, cultural services, cultural resources, and cultural platforms, bringing individuals with richer humanistic experience, increasing economic benefits for the cultural sector, and promoting the development of cultural heritage protection and education. At present, IoCT has received widespread attention in both industry and academia. To explore new research opportunities and assist users in constructing suitable IoCT systems for specific applications, this survey provides a comprehensive overview of the More >

M. Vinoth Kumar^1,*, M. Prakash², M. Naresh Kumar³, H. Abdul Shabeer⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1277-1293, 2023, DOI:10.32604/iasc.2023.025591 - 19 July 2022

Abstract The most noteworthy neurodegenerative disorder nationwide is apparently the Alzheimer's disease (AD) which ha no proven viable treatment till date and despite the clinical trials showing the potential of preclinical therapy, a sensitive method for evaluating the AD has to be developed yet. Due to the correlations between ocular and brain tissue, the eye (retinal blood vessels) has been investigated for predicting the AD. Hence, en enhanced method named Enhanced Long Short Term Memory (E-LSTM) has been proposed in this work which aims at finding the severity of AD from ocular biomarkers. To find the… More >

L. K. Shoba^1,*, P. Mohan Kumar²

Computer Systems Science and Engineering, Vol.44, No.1, pp. 613-628, 2023, DOI:10.32604/csse.2023.024449 - 01 June 2022

Abstract Nowadays in the medical field, imaging techniques such as Optical Coherence Tomography (OCT) are mainly used to identify retinal diseases. In this paper, the Central Serous Chorio Retinopathy (CSCR) image is analyzed for various stages and then compares the difference between CSCR before as well as after treatment using different application methods. The first approach, which was focused on image quality, improves medical image accuracy. An enhancement algorithm was implemented to improve the OCT image contrast and denoise purpose called Boosted Anisotropic Diffusion with an Unsharp Masking Filter (BADWUMF). The classifier used here is to More >

Lakshay Khosla¹, Johan Mohd Sani², Bilal Chughtai³

Canadian Journal of Urology, Vol.29, No.4, pp. 11216-11223, 2022

Abstract Introduction: The BD PureWick System (PureWick) allows for non-invasive management of urinary incontinence (UI) by using a low-pressure suction to wick urine from an external catheter into a collection canister. The purpose of this study was to assess satisfaction of using PureWick for management of UI in the outpatient setting based on patient and caregiver feedback.
Materials and methods: Patients and caregivers utilizing PureWick completed an online questionnaire between August and October 2020. Factors evaluated included demographics, satisfaction, recommendations, and claims using multiple choice questions, checklists, 6-point Likert Scale, and open-ended questions. Patient and caregiver responses were… More >