Jialun Lin¹, Qiong Chen^1,2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1549-1561, 2024, DOI:10.32604/cmes.2023.029631

Abstract Watermarks can provide reliable and secure copyright protection for optical coherence tomography (OCT) fundus images. The effective image segmentation is helpful for promoting OCT image watermarking. However, OCT images have a large amount of low-quality data, which seriously affects the performance of segmentation methods. Therefore, this paper proposes an effective segmentation method for OCT fundus image watermarking using a rough convolutional neural network (RCNN). First, the rough-set-based feature discretization module is designed to preprocess the input data. Second, a dual attention mechanism for feature channels and spatial regions in the CNN is added to enable the model to adaptively select… More >

Sayyid Kamran Hussain¹, Ali Haider Khan^2,*, Malek Alrashidi³, Sajid Iqbal⁴, Qazi Mudassar Ilyas⁴, Kamran Shah⁵

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3763-3781, 2023, DOI:10.32604/cmc.2023.041722

Abstract As ocular computer-aided diagnostic (CAD) tools become more widely accessible, many researchers are developing deep learning (DL) methods to aid in ocular disease (OHD) diagnosis. Common eye diseases like cataracts (CATR), glaucoma (GLU), and age-related macular degeneration (AMD) are the focus of this study, which uses DL to examine their identification. Data imbalance and outliers are widespread in fundus images, which can make it difficult to apply many DL algorithms to accomplish this analytical assignment. The creation of effcient and reliable DL algorithms is seen to be the key to further enhancing detection performance. Using the analysis of images of… More >

LINGYAN LV^1,2,#, JING ZHAO^1,2,#, XUAN WANG^1,2, LIUYAN XU^1,2, YINGYI FAN², CHUNHUI WANG³, HONGQIAO FAN^4,5,*, XIAOHUA PEI^5,*

BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

SHIMING YE^1,2,#, YUFENG ZHANG^3,#, TING LIU⁴, CONG WANG³, ZHENG YAN⁵, WANDONG SHE^2,*, HAIBING HUA^4,*

BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333

Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A compound-target network was… More >

CHENHAO SHI¹, MAOHONG HUA², GUANHUA XU^3,*

BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381

Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify the findings. A total… More >

Mahmoud A. Abdelghany^1,4, Mohamed Fathy Abo Sree², Arpan Desai³, Ahmed A. Ibrahim^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.2, pp. 1999-2015, 2023, DOI:10.32604/cmes.2023.023643

Abstract A 4-port multiple-input multiple-output (MIMO) antenna exhibiting low mutual coupling and UWB performance is developed. The octagonal-shaped four-antenna elements are connected with a 50 Ω microstrip feed line that is arranged rotationally to achieve the orthogonal polarization for improving the MIMO system performance. The antenna has a wideband impedance bandwidth of 7.5 GHz with S₁₁ < −10 dB from (103.44%) 3.5–11 GHz and inter-element isolation higher than 20 dB. Antenna validation is carried out by verifying the simulated and measured results after fabricating the antenna. The results in the form of omnidirectional radiation patterns, peak gain (≥4 dBi), and Envelope Correlation Coefficient (ECC) (≤0.01) are extracted to validate… More > Graphic Abstract

YAO LU^1,2,*, QIUYUE WANG¹, CAIHUI ZHANG¹

BIOCELL, Vol.47, No.2, pp. 393-400, 2023, DOI:10.32604/biocell.2023.024944

Abstract Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3)… More >

Xiaoting Liang¹, Fang Liu^1,*, Linqi Wang¹, Baoying Zheng¹, Yiyuan Sun²

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 469-488, 2023, DOI:10.32604/cmc.2023.029641

Abstract Driven by the visions of the Internet of Things (IoT), Artificial Intelligence (AI), and 5G communications, the Internet of Cultural Things (IoCT) realize the comprehensive interconnection among cultural products, cultural services, cultural resources, and cultural platforms, bringing individuals with richer humanistic experience, increasing economic benefits for the cultural sector, and promoting the development of cultural heritage protection and education. At present, IoCT has received widespread attention in both industry and academia. To explore new research opportunities and assist users in constructing suitable IoCT systems for specific applications, this survey provides a comprehensive overview of the IoCT components and key technologies.… More >

Thakrittorn Pansiri¹, Attakorn Asanakham^2,*, Thoranis Deethayat², Tanongkiat Kiatsiriroat²

Energy Engineering, Vol.119, No.5, pp. 1861-1878, 2022, DOI:10.32604/ee.2022.022332

Abstract This paper proposed a new function of photovoltaic thermal (PVT) module to produce nocturnal cool water not just only generating electrical power and hot water during daytime. Experimental tests were carried out under Chiang Mai tropical climate with a 200 Wp monocrystalline PVT module having dimensions of 1.601 m × 0.828 m connected with two water tanks each of 60 L taken for hot and cool water storages. The module was facing south with 18^o inclination. The electrical load was a 200 W halogen lamp. From experiments, by taking the module as a nocturnal radiative cooling surface, the cool water temperature in… More > Graphic Abstract

M. Vinoth Kumar^1,*, M. Prakash², M. Naresh Kumar³, H. Abdul Shabeer⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1277-1293, 2023, DOI:10.32604/iasc.2023.025591

Abstract The most noteworthy neurodegenerative disorder nationwide is apparently the Alzheimer's disease (AD) which ha no proven viable treatment till date and despite the clinical trials showing the potential of preclinical therapy, a sensitive method for evaluating the AD has to be developed yet. Due to the correlations between ocular and brain tissue, the eye (retinal blood vessels) has been investigated for predicting the AD. Hence, en enhanced method named Enhanced Long Short Term Memory (E-LSTM) has been proposed in this work which aims at finding the severity of AD from ocular biomarkers. To find the level of disease severity, the… More >