Jiafei He^1,2, Ailixiati Alifu², Haifan Wang², Renwei Chen^1,2,*

Structural and Congenital Heart Disease, Vol.21, No.1, 2026, DOI:10.32604/schd.2026.075858 - 31 March 2026

Abstract Hyperglycemia in pregnancy (HIP) is an important independent risk factor for congenital heart disease (CHD) in offspring. With an increasing number of women of childbearing age experiencing gestational hyperglycemia, the impact of an intrauterine hyperglycemic environment on fetal development has drawn significant attention. However, the teratogenic mechanisms underlying its effects on cardiac development remain incompletely understood. This review systematically analyzes relevant literature to summarize its underlying mechanisms and key findings: A hyperglycemic environment disrupts cardiac neural crest cell migration, differentiation, and the proliferation/apoptosis balance of cardiomyocytes by inducing oxidative stress, endoplasmic reticulum stress, and inflammatory… More >

Francesco Chiari^1,*, Giovanni Motta², Daria Maria Filippini³, Claudio Donadio Caporale¹, Pierre Guarino¹

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073086 - 23 March 2026

Abstract Objective: Mucoepidermoid carcinoma (MEC) of the larynx is an extremely rare malignancy, accounting for less than 1% of primary laryngeal tumors. The optimal role of adjuvant therapy, particularly radiotherapy (RT), remains unclear due to limited evidence. This systematic review aimed to evaluate oncologic outcomes and the impact of adjuvant treatment in patients with early- and advanced-stage laryngeal MEC. Methods: A systematic literature search was performed according to PRISMA 2020 guidelines in PubMed/Embase, Scopus, and Cochrane for studies published up to 31 July 2025. Results: Twenty-two studies, encompassing 55 patients, were included. Early-stage (T1–T2) patients (n =… More >

Gilberto Chéchile Toniolo¹, Nuria Jornet^1,*, Jady Rojas¹, Natalia Tejedor¹, Santiago Carrara¹, Alicia Maccagno², Teresa Brufau¹

Canadian Journal of Urology, Vol.33, No.1, pp. 93-103, 2026, DOI:10.32604/cju.2026.069182 - 28 February 2026

Abstract Background: Low-dose rate (LDR) prostate brachytherapy is a recommended treatment of localized prostate cancer in current guidelines. The study aimed to determine biochemical relapse-free survival (BRFS) in patients treated with dynamic real-time low-dose rate (LDR) brachytherapy using Iodine 125 (I¹²⁵). Methods: We retrospectively reviewed 499 patients with localized prostate cancer treated with I¹²⁵ LDR real-time brachytherapy between 2003 and 2021. The mean patient age was 65 years (range: 45–84 years). Based on the National Comprehensive Cancer Network (NCCN) risk classification, 230 patients (46.1%) were categorized as low risk, 235 (47.1%) as intermediate risk, and 34 (6.8%)… More >

Gianluca Spena¹, Francesco Passaro¹, Achille Aveta¹, Roberto Contieri^1,*, Alessandro Izzo¹, Giuseppe Quarto¹, Giovanni Grimaldi¹, Luigi Castaldo¹, Dario Franzese¹, Raffaele Muscariello¹, Savio Domenico Pandolfo², Antonio Tufano³, Sisto Perdonà¹

Canadian Journal of Urology, Vol.33, No.1, pp. 117-123, 2026, DOI:10.32604/cju.2025.068026 - 28 February 2026

Abstract Background: The Da Vinci Single-Port Robotic System (Da Vinci-SP), introduced by Intuitive (CA, USA) in 2018 in the USA and in 2024 in Europe, integrates advanced features like a flexible camera and articulating instruments. It has garnered significant interest in urology. Our report presents the first described European series of Radical Prostatectomies using the Da Vinci SP at the leading Italian center, Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale” Foundation, detailing the technical differences and challenges faced by experienced multiport robotic surgeons. Methods: Sixteen patients have been enrolled and underwent Single-Port (SP) Robot-Assisted Radical… More >

Thomas Kidu¹, Harini Kethar², Haben Gebrekidan³, Haleem Farman⁴, Ahmed Sedik^4,5, Walid El-Shafai^6,7, Jawad Khan^8,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.2, 2026, DOI:10.32604/cmes.2026.076798 - 26 February 2026

Abstract Colorectal cancer is the third most diagnosed cancer worldwide, and immune checkpoint inhibitors have shown promising therapeutic outcomes in selected patient groups. This study performed a comprehensive analysis of multi-omics data from The Cancer Genome Atlas colorectal adenocarcinoma cohort (TCGA-COADREAD), accessed through cBioPortal, to develop machine learning models for predicting progression-free survival (PFS) following immunotherapy. The dataset included clinical variables, genomic alterations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), B-Raf Proto-Oncogene (BRAF), and Neuroblastoma RAS Viral Oncogene Homolog (NRAS), microsatellite instability (MSI) status, tumor mutation burden (TMB), and expression of immune checkpoint genes. Kaplan–Meier… More >

Iara Santos¹, Joana Liberal^1,2, Paulo Teixeira^1,3,4, Diana Martins^1,2,5,6, Fernando Mendes^1,2,5,6,7,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070281 - 24 February 2026

Abstract Background: The Colorectal Cancer (CRC) pathogenesis and therapeutic efficacy are influenced by the gut microbiome, making it a promising biomarker for predicting treatment responses and adverse effects. This systematic review aims to outline the gut microbiome composition in individuals with CRC undergoing the same therapeutic regimen and evaluate interindividual microbiome profile variations to better understand how these differences may influence therapeutic outcomes. Methods: Key studies investigating the microbiome’s role in therapeutic approaches for CRC were searched in both PubMed and Cochrane databases on 12 and 22 March 2025, respectively. Eligible studies included free full-text English-language… More > Graphic Abstract

Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Bryanna N. Schwartz^*, Victoria L. Pemberton, D’Andrea Freemon, Kristin M. Burns, Gail D. Pearson

Congenital Heart Disease, Vol.20, No.6, pp. 637-646, 2025, DOI:10.32604/chd.2025.073995 - 10 February 2026

Abstract Background: In the 1990s, there were few multicenter research collaborations and pediatric cardiovascular clinical trials. The National Heart, Lung, and Blood Institute at the National Institutes of Health established the Pediatric Heart Network (PHN) in 2001 to stimulate multi-center collaboration and clinical studies in children and adults with congenital heart disease (CHD) and pediatric acquired heart disease. Methods: The PHN developed a flexible infrastructure for multi-center collaborative clinical research in children and adults with CHD and pediatric acquired heart disease. The objectives of the PHN are to improve health outcomes in individuals of all ages with… More >

Ling Lin, Yasha Liang, Yunyu Chen, Rong Su, Hu Zhang, Ailing Yang^*

Congenital Heart Disease, Vol.20, No.6, pp. 703-716, 2025, DOI:10.32604/chd.2025.072819 - 10 February 2026

Abstract Background: We aimed to explore the value of echocardiography plus cardiopulmonary exercise testing (CPET) for predicting the functional status and adverse outcomes of adult patients with congenital heart disease (CHD), and to develop a multivariate prediction model. Methods: Subjects (135 in total) in this single-center prospective cohort study were enrolled from adult patients suffering from CHD treated in this hospital during January 2021 and August 2023. Standardized echocardiography and CPET were conducted on all subjects at enrollment, with such indicators as left ventricular ejection fraction (LVEF), right ventricular function parameters, peak oxygen uptake (peak VO₂), and carbon… More >

Abdul Baseet Arham¹, John M. Rieth², Michael A. O’Donnell^3,*

Canadian Journal of Urology, Vol.32, No.6, pp. 605-620, 2025, DOI:10.32604/cju.2025.063632 - 30 December 2025

Abstract Background: Genitourinary (GU) sarcomas are rare soft tissue malignancies, comprising around 2% of all GU cancers. Due to their rarity, limited data exist on optimal management and long-term outcomes. This study presents a 25-year single-institution experience, evaluating clinical presentation, treatment strategies, and survival outcomes, aims to identify trends over time and potential predictors of prognosis. Methods: A retrospective review was conducted of patients aged ≥18 years diagnosed with GU sarcomas at the University of Iowa Hospitals and Clinics (1998–2023). Data on tumor subtype, staging, histopathology, treatment modalities, and survival outcomes were analyzed. Kaplan-Meier analysis estimated… More >