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  • Open Access

    ARTICLE

    Comparative Clinical Outcomes of Right Lateral Thoracotomy and Totally Thoracoscopic Surgery for Adult Patients with Atrial Septal Defect: A Single Center, Retrospective Study

    Yushen Fang1, Zechen Li1, Jiahong Li1, Kaiyu Wang1, Gang Xu1, Shusheng Wen1,2, Jimei Chen1,2, Jian Zhuang1,2, Haiyun Yuan1,2,*, Xiaobing Liu1,2,*

    Congenital Heart Disease, Vol.20, No.3, pp. 357-368, 2025, DOI:10.32604/chd.2025.066817 - 11 July 2025

    Abstract Background: Totally thoracoscopic surgery (TTS) and right lateral thoracotomy (RLT) are both extensively utilized in the surgical repair for atrial septal defect (ASD). However, RLT is generally considered in low-weight pediatric patients as a result of restricted surgical exposure. This study aims to introduce an RLT approach for ASD repair in adults and compare its clinical outcomes with TTS. Methods: We conducted a retrospective analysis of the clinical data of 23 adult patients who underwent ASD repair at Guangdong Provincial People’s Hospital between June and October 2024. Patients were divided into two groups based on the… More >

  • Open Access

    ARTICLE

    Survival outcomes with pelvic node dissection after partial cystectomy among octogenarians with muscle-invasive bladder cancer

    Arjun Pon Avudaiappan*, Pushan Prabhakar, Hannah Baker, Mukesh K. Roy, Manuel Ozambela Jr, Christopher Gomez, Murugesan Manoharan

    Canadian Journal of Urology, Vol.32, No.3, pp. 137-143, 2025, DOI:10.32604/cju.2025.064725 - 27 June 2025

    Abstract Introduction: Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma (MIBC); however, there is a growing interest in bladder preservation alternatives among the elderly population. Guidelines indicate that partial cystectomy (PC) combined with pelvic node dissection (LND) can be considered as an alternative in carefully selected individuals. Using the National Cancer Database, we analyzed the overall survival (OS) between PC with and without LND among octogenarians. Methods: We identified octogenarians with localized muscle-invasive bladder carcinoma (cT2-3N0M0) and urothelial histology who underwent PC with or without LND between 2004 and… More >

  • Open Access

    ARTICLE

    Feasibility and short-term outcomes of robotic distal ureteroureterostomy for benign obstruction

    Jonathan A. Seaman*, Rita Palanjian, John Fitzgerald, Kyle McCormick, Joel Funk, Sunchin Kim

    Canadian Journal of Urology, Vol.32, No.3, pp. 181-187, 2025, DOI:10.32604/cju.2025.064047 - 27 June 2025

    Abstract Introduction: Distal ureteral obstruction has classically been managed by ureteroneocystostomy (UNC). The feasibility and success of robotic primary ureteroureterostomy (UU) for benign obstruction appears promising with several benefits over UNC but is poorly studied. Robotic repair offers superior visualization and precision, allowing for minimal ureteral dissection. Here we report on our experience and short-term outcomes. Materials and Methods: We identified patients who underwent robotic distal ureteroureterostomy for benign distal ureteral obstruction at our institution from 2020–2024. Etiology, stricture length, and post-operative outcomes were recorded. All patients had renal ultrasound (US), diuretic renography, or cross-sectional imaging within… More >

  • Open Access

    ARTICLE

    Leaders’ expectations of innovation and employees’ innovative behavior: The roles of employees’ expected positive performance outcomes and innovative self-efficacy

    Qian Ma1, Hao Zhou2,*

    Journal of Psychology in Africa, Vol.35, No.1, pp. 7-19, 2025, DOI:10.32604/jpa.2025.065775 - 30 April 2025

    Abstract Employees’ innovative performance determines an organization’s innovation, which critically impacts its structural optimization and sustainability. Applying expectancy theory, we examined how and when the Pygmalion effect occurs in the relationship between leaders’ expectations of innovation and employee innovative behavior. Our sample comprised 201 frontline employees (female = 31.84%; mean age = 41.48 years, SD = 7.97 years) in a Chinese coal enterprise, who completed surveys on innovation expectations of leaders, expected positive performance outcomes, innovative self-efficacy and innovative behavior. The results revealed that employees’ expected positive performance outcomes mediated the positive relationship between leaders’ innovation More >

  • Open Access

    ARTICLE

    Comparing functional outcomes of glansectomy with or without glans reconstruction

    Mihály Murányi1,*, András Domoszlai1, Attila Csaba Nagy2, Tibor Flaskó1

    Canadian Journal of Urology, Vol.32, No.2, pp. 119-127, 2025, DOI:10.32604/cju.2025.063821 - 30 April 2025

    Abstract Introduction: We aimed to compare the oncological and functional outcomes of glansectomy and split-thickness skin graft reconstruction (GR) with those of glansectomy alone (GA) and penile amputation (PA). Materials and Methods: This retrospective study included patients with penile carcinoma or penile intraepithelial neoplasia diagnosed between 2017 and 2022. Surgical outcomes, complications, and oncological outcomes were assessed through a chart review, and functional outcomes were assessed using a questionnaire administered to patients who underwent GR (group A), GA (group B), or PA (group C). Results: Six, eight, and seven patients were enrolled in groups A, B, and… More >

  • Open Access

    ARTICLE

    Sacrocolpopexy in urology versus gynecology: a contemporary analysis of outcomes and patient profiles

    Yash B. Shah1, Courtney E. Capella1,*, Rishabh K. Simhal2, Maria J. D’Amico1, Whitney Smith1, Alana M. Murphy1

    Canadian Journal of Urology, Vol.32, No.1, pp. 63-70, 2025, DOI:10.32604/cju.2025.064711 - 20 March 2025

    Abstract Introduction: With the aging population, more females will suffer from pelvic organ prolapse. Both urologists and gynecologists perform sacrocolpopexy, but there is no comparative study analyzing differences in provision of care, outcomes, or patient population. We aimed to elucidate potential differences in demographics, outcomes, and minimally invasive surgery utilization for SCP performed by urology and gynecology. Methods: In our retrospective analysis, sacrocolpopexies were identified using the American College of Surgeons National Surgical Quality Improvement Project database from 2006–2020. Pearson’s chi-square test was performed to test trends in the utilization of MIS in five-year blocks. Frailty… More >

  • Open Access

    ARTICLE

    The new gold standard for surgical management of BPH: an institutional experience with 1000 HoLEPs

    Yash B. Shah1, Brian H. Im1, Aaron R. Hochberg1, Elliott P. Freudenburg2, James Jiang2, Bruce M. Gao2, Mihir S. Shah1, Akhil K. Das2,*

    Canadian Journal of Urology, Vol.32, No.1, pp. 15-19, 2025, DOI:10.32604/cju.2025.064708 - 20 March 2025

    Abstract Introduction: Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent, endoscopic management option for benign prostatic hyperplasia (BPH). HoLEP offers a distinct advantage for patients who are at high-risk for bleeding whilst preserving prostatic tissue for pathology analysis, unlike photoselective vaporization. Further, HoLEP avoids the need for cystotomy, unlike simple open and robotic prostatectomy, by using intravesical morcellation. We report our experience with the first 1000 HoLEP procedures at our institution. Materials and Methods: We performed a retrospective review of all HoLEP procedures performed at our institution from 2013–2021 to capture patient demographics, procedure details,… More >

  • Open Access

    ARTICLE

    Post-operative outcomes in rectourethral fistula repair using gracilis interposition flap

    Gabrielle Yankelevich1,*, Jessica Swaim1, Ian Coate1, Margaret Stroud1, William Stallings1, Virgilio George2, M. Lance Tavana3, Harry Clarke1

    Canadian Journal of Urology, Vol.32, No.1, pp. 37-42, 2025, DOI:10.32604/cju.2025.064684 - 20 March 2025

    Abstract Objectives: To assess outcomes of rectourethral fistula repair utilizing a gracilis flap in a largely radiated cohort. Patients and Methods: We performed a retrospective review of all gracilis interposition flap reconstruction surgeries performed for RUF at a university hospital in South Carolina between January 2010 and June 2023. All repairs utilized a multidisciplinary approach with urology, colorectal, and plastic surgery teams. Post-operatively, patients were maximally drained with foley catheter and suprapubic tube (SPT). Initial voiding cystourethrogram (VCUG) was performed at 4 weeks post-repair. If there was a persistent leak, catheter drainage was maintained for 4 additional… More >

  • Open Access

    REVIEW

    The effect of concomitant drugs on oncological outcomes in patients treated with immunotherapy for metastatic urothelial carcinoma: a narrative review

    MICHELE MAFFEZZOLI1,2,#, GIULIA CLAIRE GIUDICE1,2,#,*, GIACOMO IOVANE1,2, MARTINA MANINI1,2, ELENA RAPACCHI1, GIUSEPPE CARUSO1, NICOLA SIMONI3, STEFANIA FERRETTI4, STEFANO PULIATTI4, DAVIDE CAMPOBASSO5, SEBASTIANO BUTI1,2

    Oncology Research, Vol.33, No.4, pp. 741-757, 2025, DOI:10.32604/or.2024.057278 - 19 March 2025

    Abstract Background: immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic urothelial carcinoma (mUC), significantly improving survival outcomes. However, a subset of patients do not respond to ICIs, prompting research into potential predictive factors. Commonly prescribed medications such as corticosteroids, proton-pump inhibitors (PPIs), antibiotics (Abs), antihypertensives, and analgesics may influence ICI effectiveness. Methods: we conducted a literature search on PubMed to investigate the impact of concomitant medications on the outcomes of patients with mUC, treated with ICIs. We selected the most relevant studies and performed a narrative review. Results: corticosteroids, PPIs and Abs have been associated More >

  • Open Access

    REVIEW

    Reverse Potts Shunt in Children with Suprasystemic Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

    Yong An1,2, Gang Wang1,2, Jiangtao Dai1,2, Zhengxia Pan1,2, Yuhao Wu1,2,*

    Congenital Heart Disease, Vol.20, No.1, pp. 1-12, 2025, DOI:10.32604/chd.2025.063152 - 18 March 2025

    Abstract Background Pulmonary arterial hypertension (PAH) is a progressive condition with a poor prognosis in children. Lung transplantation (Ltx) remains the ultimate option when patients are refractory to PAH-specific therapy. Reverse Potts shunt (RPS) has been introduced to treat suprasystemic PAH. This study aims to investigate the clinical outcomes of suprasystemic PAH in children. Methods Embase, Pubmed, and the Cochrane Library databases were searched for related studies that reported the clinical outcomes of suprasystemic PAH following RPS in children. To investigate the clinical outcomes of RPS, meta-analyses of the early and overall mortalities were performed. Results Nine studies… More >

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