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  • Open Access

    ARTICLE

    Enhancing Sound Absorption in Micro-Perforated Panel and Porous Material Composite in Low Frequencies: A Numerical Study Using FEM

    Mohammad Javad SheikhMozafari*

    Sound & Vibration, Vol.58, pp. 81-100, 2024, DOI:10.32604/sv.2024.048897

    Abstract Mitigating low-frequency noise poses a significant challenge for acoustic engineers, due to their long wavelength, with conventional porous sound absorbers showing limitations in attenuating such noise. An effective strategy involves combining porous materials with micro-perforated plates (MPP) to address this issue. Given the significant impact of structural variables like panel thickness, hole diameter, and air gap on the acoustic characteristics of MPP, achieving the optimal condition demands numerous sample iterations. The impedance tube’s considerable expense for sound absorption measurement and the substantial cost involved in fabricating each sample using a 3D printer underscore the advantage of utilizing simulation methods to… More > Graphic Abstract

    Enhancing Sound Absorption in Micro-Perforated Panel and Porous Material Composite in Low Frequencies: A Numerical Study Using FEM

  • Open Access

    ARTICLE

    A Sound Quality Evaluation Method for Vehicle Interior Noise Based on Auditory Loudness Model

    Zhiheng He1, Hui Guo2, Houguang Liu1,*, Yu Zhao1,3, Zipeng Zhang1, Shanguo Yang1

    Sound & Vibration, Vol.58, pp. 47-58, 2024, DOI:10.32604/sv.2024.045470

    Abstract When designing and optimizing the hull of vehicles, their sound quality needs to be considered, which greatly depends on the psychoacoustic parameters. However, the traditional psychoacoustic calculation method does not consider the influence of the real human ear anatomic structure, even the loudness which is most related to the auditory periphery. In order to introduce the real physiological structure of the human ear into the evaluation of vehicle sound quality, this paper first carried out the vehicle internal noise test to obtain the experimental samples. Then, the physiological loudness was predicted based on an established human ear physiological model, and… More >

  • Open Access

    ARTICLE

    Abstractive Arabic Text Summarization Using Hyperparameter Tuned Denoising Deep Neural Network

    Ibrahim M. Alwayle1, Hala J. Alshahrani2, Saud S. Alotaibi3, Khaled M. Alalayah1, Amira Sayed A. Aziz4, Khadija M. Alaidarous1, Ibrahim Abdulrab Ahmed5, Manar Ahmed Hamza6,*

    Intelligent Automation & Soft Computing, Vol.38, No.2, pp. 153-168, 2023, DOI:10.32604/iasc.2023.034718

    Abstract Abstractive text summarization is crucial to produce summaries of natural language with basic concepts from large text documents. Despite the achievement of English language-related abstractive text summarization models, the models that support Arabic language text summarization are fewer in number. Recent abstractive Arabic summarization models encounter different issues that need to be resolved. Syntax inconsistency is a crucial issue resulting in the low-accuracy summary. A new technique has achieved remarkable outcomes by adding topic awareness in the text summarization process that guides the module by imitating human awareness. The current research article presents Abstractive Arabic Text Summarization using Hyperparameter Tuned… More >

  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

  • Open Access

    REVIEW

    Stem cell technology for antitumor drug loading and delivery in oncology

    FRANCESCO PETRELLA*, ENRICO MARIO CASSINA, LIDIA LIBRETTI, EMANUELE PIRONDINI, FEDERICO RAVEGLIA, ANTONIO TUORO

    Oncology Research, Vol.32, No.3, pp. 433-437, 2024, DOI:10.32604/or.2023.046497

    Abstract The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing drug effects and, at the same time, reducing the damage of non-involved tissues to cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family cells. During the last year, they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cells, thus optimizing cytotoxic action on cancer cells, while significantly reducing adverse side effects… More >

  • Open Access

    ARTICLE

    Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

    XING YE1,#, ZHOUTING TUO2,#, KAI CHEN3, RUICHENG WU3, JIE WANG3, QINGXIN YU4, LUXIA YE5, AKIRA MIYAMOTO6, KOO HAN YOO7, CHI ZHANG8, WURAN WEI3, DENGXIONG LI3,*, DECHAO FENG3,*

    Oncology Research, Vol.32, No.3, pp. 503-515, 2024, DOI:10.32604/or.2024.045050

    Abstract The increasing interest in RNA modifications has significantly advanced epigenomic and epitranscriptomic technologies. This study focuses on the immuno-oncological impact of ALYREF in human cancer through a pan-cancer analysis, enhancing understanding of this gene’s role in cancer. We observed differential ALYREF expression between tumor and normal samples, correlating strongly with prognosis in various cancers, particularly kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC). ALYREF showed a negative correlation with most tumor-infiltrating cells in lung squamous cell carcinoma (LUSC) and lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), while positive correlations were noted in LIHC, kidney chromophobe (KICH), mesothelioma… More >

  • Open Access

    REVIEW

    A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma

    ELHAM AMJAD1, RAFFAELE PEZZANI2,3,*, BABAK SOKOUTI1,*

    Oncology Research, Vol.32, No.3, pp. 439-461, 2024, DOI:10.32604/or.2023.044473

    Abstract Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient’s outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of the use of the CRISPR/Cas9 system for the treatment of cancer, with a particular emphasis on HCC as part of the current state… More >

  • Open Access

    ARTICLE

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

    HUI SUN, MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

    Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

    Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

  • Open Access

    ARTICLE

    MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway

    YUANYUAN XU, XIAOKE CHEN*

    Oncology Research, Vol.32, No.3, pp. 517-528, 2024, DOI:10.32604/or.2023.030293

    Abstract Background: The aberrant intracellular expression of a mitochondrial aspartyl-tRNA synthetase 2 (DARS2) has been reported in human cancers. Nevertheless, its critical role and detailed mechanism in lung adenocarcinoma (LUAD) remain unexplored. Methods: Initially, The Cancer Genome Atlas (TCGA)-based Gene Expression Profiling Interactive Analysis (GEPIA) database () was used to analyze the prognostic relevance of DARS2 expression in LUAD. Further, cell counting kit (CCK)-8, immunostaining, and transwell invasion assays in LUAD cell lines in vitro, as well as DARS2 silence on LUAD by tumorigenicity experiments in vivo in nude mice, were performed. Besides, we analyzed the expression levels of p-PI3K (phosphorylated-Phosphotylinosital3… More >

  • Open Access

    ARTICLE

    Psychological Anxiety Intervention for Young Audiences: Effectiveness Evaluation of Art Museums

    Jingjing Zhou1, Yungneng Lin2,*, Tingting Huang1

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 39-49, 2024, DOI:10.32604/ijmhp.2023.045203

    Abstract The mental health of young people, a significant public health concern worldwide, has deteriorated during the COVID-19 pandemic. Despite the subsiding of the epidemic, the issue remains unresolved in the post-pandemic era, specifically in China. In response, numerous art museums have stepped up to provide long-term therapeutic experiences and comprehensive mental health support. While these institutions offer a variety of services and programs aimed at enhancing the psychological well-being of their visitors, a standardized method for assessing their impact is lacking. This study, therefore, employed the Generic Wellbeing Questionnaire (GWQ) as a tool to evaluate the decrease in psychological anxiety… More >

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