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  • Open Access

    ARTICLE

    An Intelligent Framework for Resilience Recovery of FANETs with Spatio-Temporal Aggregation and Multi-Head Attention Mechanism

    Zhijun Guo1, Yun Sun2,*, Ying Wang1, Chaoqi Fu3, Jilong Zhong4,*

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2375-2398, 2024, DOI:10.32604/cmc.2024.048112

    Abstract Due to the time-varying topology and possible disturbances in a conflict environment, it is still challenging to maintain the mission performance of flying Ad hoc networks (FANET), which limits the application of Unmanned Aerial Vehicle (UAV) swarms in harsh environments. This paper proposes an intelligent framework to quickly recover the cooperative coverage mission by aggregating the historical spatio-temporal network with the attention mechanism. The mission resilience metric is introduced in conjunction with connectivity and coverage status information to simplify the optimization model. A spatio-temporal node pooling method is proposed to ensure all node location features can be updated after destruction… More >

  • Open Access

    ARTICLE

    Static Analysis Techniques for Fixing Software Defects in MPI-Based Parallel Programs

    Norah Abdullah Al-Johany1,*, Sanaa Abdullah Sharaf1,2, Fathy Elbouraey Eassa1,2, Reem Abdulaziz Alnanih1,2,*

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3139-3173, 2024, DOI:10.32604/cmc.2024.047392

    Abstract The Message Passing Interface (MPI) is a widely accepted standard for parallel computing on distributed memory systems. However, MPI implementations can contain defects that impact the reliability and performance of parallel applications. Detecting and correcting these defects is crucial, yet there is a lack of published models specifically designed for correcting MPI defects. To address this, we propose a model for detecting and correcting MPI defects (DC_MPI), which aims to detect and correct defects in various types of MPI communication, including blocking point-to-point (BPTP), nonblocking point-to-point (NBPTP), and collective communication (CC). The defects addressed by the DC_MPI model include illegal… More >

  • Open Access

    ARTICLE

    Research on Performance Optimization of Spark Distributed Computing Platform

    Qinlu He1,*, Fan Zhang1, Genqing Bian1, Weiqi Zhang1, Zhen Li2

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2833-2850, 2024, DOI:10.32604/cmc.2024.046807

    Abstract Spark, a distributed computing platform, has rapidly developed in the field of big data. Its in-memory computing feature reduces disk read overhead and shortens data processing time, making it have broad application prospects in large-scale computing applications such as machine learning and image processing. However, the performance of the Spark platform still needs to be improved. When a large number of tasks are processed simultaneously, Spark’s cache replacement mechanism cannot identify high-value data partitions, resulting in memory resources not being fully utilized and affecting the performance of the Spark platform. To address the problem that Spark’s default cache replacement algorithm… More >

  • Open Access

    ARTICLE

    Fortifying Healthcare Data Security in the Cloud: A Comprehensive Examination of the EPM-KEA Encryption Protocol

    Umi Salma Basha1, Shashi Kant Gupta2, Wedad Alawad3, SeongKi Kim4,*, Salil Bharany5,*

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3397-3416, 2024, DOI:10.32604/cmc.2024.046265

    Abstract A new era of data access and management has begun with the use of cloud computing in the healthcare industry. Despite the efficiency and scalability that the cloud provides, the security of private patient data is still a major concern. Encryption, network security, and adherence to data protection laws are key to ensuring the confidentiality and integrity of healthcare data in the cloud. The computational overhead of encryption technologies could lead to delays in data access and processing rates. To address these challenges, we introduced the Enhanced Parallel Multi-Key Encryption Algorithm (EPM-KEA), aiming to bolster healthcare data security and facilitate… More >

  • Open Access

    ARTICLE

    Design Pattern and Challenges of Federated Learning with Applications in Industrial Control System

    Hina Batool1, Jiuyun Xu1,*, Ateeq Ur Rehman2, Habib Hamam3,4,5,6

    Journal on Artificial Intelligence, Vol.6, pp. 105-128, 2024, DOI:10.32604/jai.2024.049912

    Abstract Federated Learning (FL) appeared as an encouraging approach for handling decentralized data. Creating a FL system needs both machine learning (ML) knowledge and thinking about how to design system software. Researchers have focused a lot on the ML side of FL, but have not paid enough attention to designing the software architecture. So, in this survey, a set of design patterns is described to tackle the design issues. Design patterns are like reusable solutions for common problems that come up when designing software architecture. This paper focuses on (1) design patterns such as architectures, frameworks, client selection protocols, personalization techniques,… More >

  • Open Access

    ARTICLE

    Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

    YI HU1,#, ZHONGYANG REN2,#, ZHENGZHONG ZHAO1, YONGJIA HUANG3, WANTING HUANG3, JIE LIU3,*, LING DING3,*

    BIOCELL, Vol.48, No.5, pp. 745-758, 2024, DOI:10.32604/biocell.2024.049140

    Abstract Background: Acute pancreatitis (AP), known for its rapid onset and significant incidence and mortality rates, presents a clinical challenge due to the limited availability of effective treatments and preventive measures. Anemarsaponin B (ASB) has emerged as a potential therapeutic agent, demonstrating capabilities in reducing immune inflammation, positioning it as a promising candidate for AP treatment. Methods: We investigated the effects of ASB on AP in mice, induced by caerulein and lipopolysaccharide (LPS). Peripheral blood samples were collected 24 h post-induction with caerulein to assess of key biomarkers including lipase, amylase, TNF-α, IL-1β, IL-6, SOD, and GSH-Px. A range of techniques… More >

  • Open Access

    REVIEW

    Pathogenic genes associated with Parkinson’s disease: molecular mechanism overview

    TINGTING LIU1,#, YIWEI HAO2,#, LIFENG ZHAO2,*

    BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130

    Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry other mutation sites that increase… More >

  • Open Access

    ARTICLE

    Quercetin regulates depression-like behavior in CUMS rat models via TLR4/NF-κB signaling

    YUANYUAN LI1, BITAO ZHANG1, ZILONG CUI1, PEIJIAN FAN1, SHAOXIAN WANG1,2,*

    BIOCELL, Vol.48, No.5, pp. 731-744, 2024, DOI:10.32604/biocell.2024.048820

    Abstract Background: Depression is becoming increasingly prevalent around the world, imposing a substantial burden on individuals, families, as well as society. Quercetin is known to be highly effective in treating depression. However, additional research is needed to dissect the mechanisms of its anti-depressive effects. Methods: For this study, Sprague-Dawley (SD) rats were randomized into the control, model, quercetin, or fluoxetine group. The latter three groups were exposed to chronic unpredictable mild stress (CUMS) for 42 d. The first two groups received saline solution daily via oral gavage. Meanwhile, the quercetin group was orally administered a quercetin suspension (52.08 mg/kg) every day,… More >

  • Open Access

    REVIEW

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

    VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI*

    BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776

    Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical level. This review… More > Graphic Abstract

    Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

  • Open Access

    ARTICLE

    3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

    XIAOQI WU1,2,#, YECHUAN HE1,2,#, YEQIN YUAN4, XIAN TAN1,2, LIN ZHU1,2, DANLING WANG1,2,4, BINYUAN JIANG3,4,*

    BIOCELL, Vol.48, No.5, pp. 861-872, 2024, DOI:10.32604/biocell.2024.048758

    Abstract Background: Nasopharyngeal carcinoma (NPC) exhibits a significant prevalence in the southern regions of China, and paclitaxel (PTX) is frequently employed as a medication for managing advanced NPC. However, drug resistance is typically accompanied by a poor prognosis. Exploring the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment efficacy. Methods: This study investigated whether 3-Methyladenine (3-MA) could potentiated the effect of PTX and its potential molecular mechanism. Samples were divided into the following categories: Negative control (NC) with the solvent dimethyl sulfoxide (DMSO, 0.5% v/v), PTX (400 nM), 3-MA (4 mM), and PTX (400… More >

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