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  • Open Access

    ARTICLE

    Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. Y. Li

    Jiaqi Lang1, Mingyan Ye1, Ya Luo1, Yueheng Wang1, Zhifen Shi1,2, Xiaotian Kong1,3, Xuan Li1, Nong Zhou1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 789-806, 2024, DOI:10.32604/phyton.2024.049088

    Abstract This study aimed to examine the effects of inoculating Fritillaria taipaiensis P.Y.Li leaves with different strains of potassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiological and biochemical characteristics. At present, some studies have only studied the rhizosphere microbial community characteristics of F. taipaiensis and have not discussed the effects of different microbial species on the growth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria to conduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October 2022. The growth of F. taipaiensis leaves… More >

  • Open Access

    ARTICLE

    Analyze the Performance of Electroactive Anticorrosion Coating of Medical Magnesium Alloy Using Deep Learning

    Yashan Feng1, Yafang Tian1, Yongxin Yang1, Yufang Zhang1, Haiwei Guo1, Jing’an Li2,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 263-278, 2024, DOI:10.32604/cmc.2024.047004

    Abstract Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. The study employs strategic thermodynamic equilibrium calculations to pioneer a novel factor in corrosion protection. A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medical magnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoretical insights and practical applications to enhance our grasp of corrosion prevention mechanisms and establish a systematic approach to coating design. The groundbreaking significance of this study lies in its innovative integration of the TA/pH concept, which encompasses the TA/pH ratio of the chemical environment.… More >

  • Open Access

    REVIEW

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

    NILAM BHUSARE, MAUSHMI KUMAR*

    Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

    Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

  • Open Access

    REVIEW

    Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

    YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

    BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056

    Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

  • Open Access

    REVIEW

    A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

    JHILAM PRAMANIK1,#, AKASH KUMAR2, SARVESH RUSTAGI3,#, MEHAK KATYAL4, SHEETAL THAKUR5, JUTISHNA BORA6, SUMIRA MALIK6,7,*, ANCHAL TREHAN8, NAYAN TALUKDAR9, PETR SLAMA10,*

    BIOCELL, Vol.48, No.4, pp. 541-557, 2024, DOI:10.32604/biocell.2023.029031

    Abstract Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods, pharmaceutical products as well as in the environmental and medical fields. However, these secondary metabolites obtained from plants are in low amounts, and it is difficult to synthesize them at the industrial level. Despite these challenges, they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested. Secondary metabolites are complex compounds that exhibit chirality. Further, under controlled conditions with elicitors, desired secondary metabolites may be produced from plant cell cultures. This review… More > Graphic Abstract

    A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

  • Open Access

    ARTICLE

    Anionic Polymerization of ε-Caprolactone Using Potassium tert-Butoxide/18-Crown-6 Initiating System

    YAN WANGA, LI-FANG ZHANGA,B,C,*, XIAO-QI WANGB

    Journal of Polymer Materials, Vol.37, No.1-2, pp. 77-89, 2020, DOI:10.32381/JPM.2020.37.1-2.6

    Abstract The effect of 18-crown-6 ether (18C6) on the anionic polymerization of ε-caprolactone (ε -CL) using potassium tert-butoxide (t-BuOK) as the initiator was studied. The experimental results showed that 18C6 in combination with t-BuOK exhibited high selectivity for ring opening relative to trans-esterification and improved control toward the ROP of ε-CL, producing poly(ε- caprolactone) (PCL) with much higher molecular weight and relatively narrow distribution compared to those using t-BuOK alone as the initiator.The influences of reaction conditions, such as monomer concentration, monomer/initiator molar ratio, and [18C6]/[t-BuOK] molar ratio, as well as reaction temperature and time on the polymerization have been examined… More >

  • Open Access

    ARTICLE

    Swelling dynamics of Poly (N, N- Dimethylacrylamide - co- Crotonic acid) Hydrogel and Evaluation of its Potential for Controlled Release of Fertilizers

    FATMA LOUZRI, SADJIA BENNOUR

    Journal of Polymer Materials, Vol.37, No.1-2, pp. 55-76, 2020, DOI:10.32381/JPM.2020.37.1-2.5

    Abstract Poly(N,N-dimethymethylacrylamide -co-crotonic acid) (P(DMA-CAx)) hydrogels were prepared by free radical polymerization, using N,N- methylenebisacrylamide (NMBA) as cross-linking agent. The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The effects of comonomer composition and pH of the medium on the swelling behavior of hydrogels were investigated. The obtained results showed that the swelling capabilities of hydrogels increased as crotonic acid content and pH increased. In order to evaluate the controlled release potential of the polymeric matrix, it was loaded with potassium nitrate and ammonium nitrate as fertilizers and the release kinetics was studied as a… More >

  • Open Access

    ARTICLE

    Development of Chitosan-based Films Containing Hypericum perforatum L. and Citrus limon L. as Potential Wound Dressing Materials

    DENIZ AKIN SAHBAZ1,*, BETUL TURP KAYA2

    Journal of Polymer Materials, Vol.38, No.3-4, pp. 247-256, 2021, DOI:10.32381/JPM.2021.38.3-4.6

    Abstract The objective of this study is to develop chitosan-based films containing Hypericum perforatum L. and/or Citrus limon L. oils and to investigate their suitability as novel wound dressing materials. The morphology of the chitosan-based films were observed by means of employing the scanning electron microscopy (SEM) and the chemical structure characterization was performed via Fourier Transform Infrared Spectroscopy (FTIR). Hypericum perforatum L. and/or Citrus limon L. were successfully incorporated to the chitosan films. Antibacterial, swelling, and mechanical properties of these films were investigated. The antibacterial property was enhanced by incorporating Hypericum perforatum L. and Citrus limon L. oils in the… More >

  • Open Access

    ARTICLE

    Path Planning for AUVs Based on Improved APF-AC Algorithm

    Guojun Chen*, Danguo Cheng, Wei Chen, Xue Yang, Tiezheng Guo

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3721-3741, 2024, DOI:10.32604/cmc.2024.047325

    Abstract With the increase in ocean exploration activities and underwater development, the autonomous underwater vehicle (AUV) has been widely used as a type of underwater automation equipment in the detection of underwater environments. However, nowadays AUVs generally have drawbacks such as weak endurance, low intelligence, and poor detection ability. The research and implementation of path-planning methods are the premise of AUVs to achieve actual tasks. To improve the underwater operation ability of the AUV, this paper studies the typical problems of path-planning for the ant colony algorithm and the artificial potential field algorithm. In response to the limitations of a single… More >

  • Open Access

    ARTICLE

    Development of a cell adhesion-based prognostic model for multiple myeloma: Insights into chemotherapy response and potential reversal of adhesion effects

    QIAN HU, MENGYAO WANG, JINJIN WANG, YALI TAO, TING NIU*

    Oncology Research, Vol.32, No.4, pp. 753-768, 2024, DOI:10.32604/or.2023.043647

    Abstract Multiple myeloma (MM) is a hematologic malignancy notorious for its high relapse rate and development of drug resistance, in which cell adhesion-mediated drug resistance plays a critical role. This study integrated four RNA sequencing datasets (CoMMpass, GSE136337, GSE9782, and GSE2658) and focused on analyzing 1706 adhesion-related genes. Rigorous univariate Cox regression analysis identified 18 key prognosis-related genes, including KIF14, TROAP, FLNA, MSN, LGALS1, PECAM1, and ALCAM, which demonstrated the strongest associations with poor overall survival (OS) in MM patients. To comprehensively evaluate the impact of cell adhesion on MM prognosis, an adhesion-related risk score (ARRS) model was constructed using Lasso… More >

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