XIANGDONG SUN^1,2,#, HUIJUAN WEN^1,2,#, FAZHAN LI^1,2, IHTISHAM BUKHARI^1,2, FEIFEI REN^1,2, XIA XUE^1,2, PENGYUAN ZHENG^1,2,*, YANG MI^1,2,*

Oncology Research, Vol.32, No.2, pp. 283-296, 2024, DOI:10.32604/or.2023.044618

Abstract Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs). Furthermore, we validated the expression of NMRGs in gastric cancer (GC) tissues and cell lines; additionally, β-nicotinamide mononucleotide (NMN), a precursor of NAD+, was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation, cell cycle, apoptosis, and senescence-associated secretory… More > Graphic Abstract

YAFEI WANG^1,2,#, JIELEI NI^1,#, YUHAN LIU², DINGYING LIAO³, QIANWEN ZHOU¹, XIAOYANG JI², GANG NIU², YANXIANG NI^1,*

BIOCELL, Vol.47, No.12, pp. 2567-2578, 2023, DOI:10.32604/biocell.2023.043781

Abstract Down syndrome (DS) is a genetic condition characterized by intellectual disability, delayed brain development, and early onset Alzheimer’s disease. The use of primary neural cells and tissues is important for understanding this disease, but there are ethical and practical issues, including availability from patients and experimental manipulability. Moreover, there are significant genetic and physiological differences between animal models and humans, which limits the translation of the findings in animal studies to humans. Advancements in induced pluripotent stem cells (iPSC) technology have revolutionized DS research by providing a valuable tool for studying the cellular and molecular pathologies associated with DS. Induced… More >

Hao Hu^1,2,3, Jian Guan⁴, Shanfa Tang^1,2,3,*, Jialuo Rong^1,2,3, Yuanpeng Cheng^1,2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.2, pp. 325-335, 2024, DOI:10.32604/fdmp.2023.042055

Abstract Different drilling fluid systems are designed according to mineral composition, lithology and wellbore stability of different strata. In the present study, the conversion of a non-dispersed polymer drilling fluid into a low potassium anti-collapsing drilling fluid is investigated. Since the two drilling fluids belong to completely different types, the key to this conversion is represented by new inhibitors, dispersants and water-loss agents by which a non-dispersed drilling fluid can be turned into a dispersed drilling fluid while ensuring wellbore stability and reasonable rheology (carrying sand—inhibiting cuttings dispersion). In particular, the (QYZ-1) inhibitors and (FSJSS-2) dispersants are used. The former can… More >

Rodrigo Vidonscky Pinto¹, Flávio Augusto Sanzovo Fiorelli^2,*

Frontiers in Heat and Mass Transfer, Vol.21, pp. 427-443, 2023, DOI:10.32604/fhmt.2023.041917

Abstract The present work provides an experimental and numerical procedure to obtain the geometrical position of the hotspots of a microprocessor using the thermal images obtained from the transient thermal response of this processor subject to pulsating stress tests. This is performed by the solution of the steady inverse heat transfer problem using these thermal images, resulting in qualitative heat source distributions; these are analyzed using the mean heat source gradients to identify the elements that can be considered hotspots. This procedure identified that the processor INTEL Core 2 Quad Q8400S contains one hotspot located in the center of its left… More >

QINGPAN BU, PING LI, YUNFEI XIA, XINPEI WEI, KAI SONG^*

BIOCELL, Vol.47, No.11, pp. 2535-2546, 2023, DOI:10.32604/biocell.2023.030781

Abstract Mannose, a different isomer of the hydroxyl group at the C-2 position of glucose, shares the same transport carrier protein with glucose to enter cells and participate in the regulation of glucose metabolism. It affects cell growth, differentiation, and function and plays an active role in tumor immunity and inflammatory processes. This paper provides theoretical support for expanding the clinical applications of mannose by exploring its constitution, metabolic pathways, and role in regulating immune cell function and treating immunology-related diseases. More > Graphic Abstract

WEILAN LIU, XIAOYAN DUAN, KAIYUN QIN, YAN JIANG, CAIFU ZHAO, CONGWEI DAI^*

BIOCELL, Vol.47, No.11, pp. 2471-2484, 2023, DOI:10.32604/biocell.2023.029617

Abstract Introduction: Structural maintenance of chromosome 1A (SMC1A) is a crucial compound of the cohesin complex. It has been reported to regulate the epithelial-mesenchymal transition (EMT) process in multiple cancers. Objectives: The present study aims to further clarify the role of SMC1A in cervical cancer. Methods: We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical cancer. Cell proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation assay. The migration and invasion were estimated by wound healing… More > Graphic Abstract

WEI HU^1,#, THOMAS WARTMANN^2,#, MARCO STRECKER², ARISTOTELIS PERRAKIS², ROLAND CRONER², ARPAD SZALLASI³, WENJIE SHI^2,*, ULF D. KAHLERT^2,*

Oncology Research, Vol.32, No.1, pp. 227-239, 2024, DOI:10.32604/or.2023.043053

Abstract Transient receptor potential (TRP) channels are strongly associated with colon cancer development and progression. This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature, with further validation of signature in real world samples from our hospital treated patient samples. Kaplan-Meier (K-M) survival analysis and receiver operating characteristic (ROC) curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts, respectively. Additionally, the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.… More > Graphic Abstract

Adekunle A. Adeleke^1,*, Nzerem Petrus², Salihu Ayuba², Asmau M. Yahya², Peter P. Ikubanni³, Ikechuckwu S. Okafor², Stephen S. Emmanuel⁴, Adebayo I. Olosho⁴, Ademidun A. Adesibikan⁴

Journal of Renewable Materials, Vol.11, No.12, pp. 4123-4141, 2023, DOI:10.32604/jrm.2023.043915

Abstract Nigeria, often referred to as “the giant of Africa,” boasts a sizable population, a thriving economy, and abundant energy resources. Nevertheless, Nigeria has yet to fully harness its renewable energy potential, despite its enormous capacity in this field. The goal of this review paper is to thoroughly examine the difficulties and untapped opportunities in utilizing biomass for bioenergy production in Nigeria. Notably, Nigeria generates substantial volumes of biomass annually, primarily in the form of agricultural waste, which is often either discarded or burned inefficiently, resulting in significant ecological and environmental damage. Therefore, an efficient approach to reducing pollution and transforming… More > Graphic Abstract

Danfeng Yuan¹, Xiangyun Yang¹, Lijuan Yang¹, Zhanjiang Li^1,2,*

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1067-1079, 2023, DOI:10.32604/ijmhp.2023.041430

Abstract Language difficulties vary widely among people with autism spectrum disorder (ASD). However, the semantic processing of autistic person and its underlying electrophysiological mechanism are still unclear. This meta-analysis aimed to explore the disturbance of semantic processing in patients with ASD. PubMed, Web of Science, and Embase were searched for event-related potential (ERP) studies on semantic processing in autistic people published in English before September 01, 2022. Pooled estimates were calculated by fixed-effects or random-effects models according to the heterogeneity using Comprehensive Meta-Analysis 2.0. The potential moderators were explored by meta-regression and subgroup analysis. This meta-analysis has been registered at the… More >

Shugufta Parveen¹, Fayaz A. Mohiddin^2,*, M. Ashraf Bhat³, Zahoor Ahmed Baba⁴, Fehim Jeelani⁵, M. Anwar Bhat⁶, Sajad Un Nabi⁷, Burhan Hamid², Saba Bandey⁸, Farhanaz Rasool⁹, Zakir Amin¹, Ibrahim Al-Ashkar^10,*, Muhammad Adnan¹¹, Ayman El Sabagh¹²

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3021-3041, 2023, DOI:10.32604/phyton.2023.030921

Abstract One hundred twenty-five endophytic microorganisms were isolated from the roots, stems, and leaves of four prominent rice cultivars growing in temperate regions. Their potential to combat rice blast disease and promote plant growth was investigated. The dual culture tests highlighted the strong antagonistic activity of five fungal (ranging from 89%–70%) and five bacterial (72%–61%) endophytes. Subsequent examination focused on volatile compounds produced by selected isolates to counter the blast pathogen. Among these, the highest chitinase (13.76 µg mL⁻¹) and siderophore (56.64%), was exhibited by Aspergillus flavus, and the highest HCN production was shown by Stenotrophomonas maltophilia (36.15 µM mL⁻¹). In… More >