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  • Open Access

    ARTICLE

    Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells

    YIFAN LI1,2, JING ZHANG1, YITAO FAN1, HANDAN XIAO1, KEXIN KANG1, YALI ZHOU1, ZHIWEN ZHANG3,*, YUMIN LI1, MUZHOU TENG1,*

    BIOCELL, Vol.47, No.8, pp. 1783-1791, 2023, DOI:10.32604/biocell.2023.028056

    Abstract Background: ((1-triphenylaminebenzo[c][1,2,5] thiadiazole-4-yl) styryl)-1-methylpyridin methylpyridin-1-ium iodide salt (TBZPy) is a novel photosensitizer that displays excellent photodynamic properties. However, There are few reports on the mechanism of action of the TBZPy photodynamic. Previous studies revealed that photodynamic therapy (PDT) could induce endoplasmic reticulum stress by acting on the endoplasmic reticulum. Therefore, in this study, we investigated the effects of endoplasmic reticulum stress induced by TBZPy-PDT in treating High-risk human papillomavirus (HR-HPV) infection and their underlying mechanisms. Methods: The human cervical cancer cell line HeLa (containing whole genome of HR-HPV18) was treated with TBZPy-PDT. Cell migration, invasion, and colony-forming ability were evaluated… More > Graphic Abstract

    Photodynamic therapy with TBZPy regulates the PI3K/AKT and endoplasmic reticulum stress-related PERK/eIF2α pathways in HeLa cells

  • Open Access

    REVIEW

    The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

    Zhengyi Li1,2,3, Lihua Qiu1,2,3,*

    Oncologie, Vol.23, No.4, pp. 515-531, 2021, DOI:10.32604/oncologie.2021.019856

    Abstract Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies… More >

  • Open Access

    ARTICLE

    IR780 loaded hollow MnO2 nanoparticles for dual-mode imaging and enhanced photodynamic therapy of oral squamous cell carcinoma

    WEI PAN1,2,3,*, YE HE1, MENGDONG HE1,2,3, FEI WANG1,2,3, LIHUA QIU1,2

    BIOCELL, Vol.46, No.4, pp. 1079-1088, 2022, DOI:10.32604/biocell.2022.016934

    Abstract Photodynamic therapy (PDT) has emerged as a novel therapeutic modality for cancer treatment, but its therapeutic efficacy is severely limited by the hypoxic tumor microenvironment (TME). Here we designed an innovative multifunctional nano-platform which consists of a hollow MnO2 shell and internal photosensitizer IR780. It is not only used for multimodal imaging of oral squamous cell carcinoma (OSCC), but also for adjustment hypoxic TME to enhance cancer treatment. Hollow MnO2 can promote decomposition of tumor endogenous H2O2 to relieve tumor hypoxia, thereby enhancing the effect of photodynamic therapy. Photosensitizer IR780 generates singlet oxygen under laser irradiation to kill tumor cells,… More >

  • Open Access

    REVIEW

    Application of photodynamic therapy in cancer: challenges and advancements

    ZIXUAN WANG1,#, HONGMEI PENG2,#, WEI SHI4,#, LU GAN1, LIPING ZHONG1, JIAN HE1, LINLIN XIE1, PAN WU1, YONGXIANG ZHAO1, ZHIMING DENG3,*, HONGLIANG TANG4, YONG HUANG1,3,*

    BIOCELL, Vol.45, No.3, pp. 489-500, 2021, DOI:10.32604/biocell.2021.014439

    Abstract Although great achievements have been made in the past decades in medicine, cancer remains a worldwide public health issue. Surgery is usually accompanied by shortcomings such as residual lesions and poor treatment effects, and the successive appearance of other treatment methods, such as radiotherapy and chemotherapy, has not changed the postoperative recurrence rate, toxicity, and side effects. However, the advent of photodynamic therapy has greatly improved this situation. Photodynamic therapy is an emerging tumor diagnosis and treatment technology with good application prospects, photodynamic therapy uses a specific wavelength of light to excite a photosensitizer to generate reactive oxygen species, damage… More >

  • Open Access

    ARTICLE

    Ultrastructural effects of two phthalocyanines in CHO-K1 and HeLa cells after laser irradiation

    Marcelo de Castro Pazos*, Cristina Pacheco-Soares*, Newton Soares da Silva*, R.A. DaMatta**, M.T.T. Pacheco*

    BIOCELL, Vol.27, No.3, pp. 301-309, 2003, DOI:10.32604/biocell.2003.27.301

    Abstract The effects of Photodynamic Therapy using 2nd generation photosensitizers have been widely investigated aiming clinical application treatment of solid neoplasms. In this work, ultrastructure changes caused by the action of two 2nd generation photosensitizers and laser irradiation on CHO-K1 and HeLa (neoplastic) cells were analyzed by transmission electron microscopy. Aluminum phthalocyanine chloride, aluminum phthalocyanine tetrasulfonate chloride and radiation from a semiconductor laser at a fluency of 0.5 J/ cm2 (Power=26mW; λ=670nm) were used. The results showed induction of apoptosis. Such alterations where observed in HeLa but not in CHO-K1 cells after Aluminum phthalocyanine tetrasulfonate chloride (AlPcS4) photodynamic treatment. The Aluminum… More >

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