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Search Results (82)
  • Open Access

    ARTICLE

    FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma

    ZHONGXIANG TANG1,2, LILI WANG1,2, GUOJUN WU1,2, LING QIN1,2,*, YURONG TAN1,2,*

    BIOCELL, Vol.47, No.11, pp. 2503-2516, 2023, DOI:10.32604/biocell.2023.031565

    Abstract Background: Non-small cell lung cancer (NSCLC) has a poor prognosis with a low 5-year survival rate. Lung adenocarcinoma (LUAD) accounts for 50%. Facio-genital dysplasia-5 (FGD5), a member of a subfamily of Rho GTP-GDP exchange factors, may be a good molecular biomarker for diagnosis and prognosis. Objective: To explore the clinical application of FGD5, the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients. Methods: Through the Wilcoxon signed-rank test and logistic regression, the correlation between clinical characteristics and FGD5 expression was analyzed. Kaplan–Meier plotter analysis, Cox regression, and a… More > Graphic Abstract

    FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma

  • Open Access

    ARTICLE

    Analysis of functional hub genes indicates DLGAP5 is linked to lung adenocarcinoma prognosis

    HAOSHENG ZHENG1,#, RUIJUN LIN2,#, WEIJIE CAI1, YUZHEN ZHENG1, XINGPING YANG1, ZUI LIU1, FEI QIN1, YONGJIE CAI3, XIANYU QIN1,*, HONGYING LIAO1,*

    BIOCELL, Vol.47, No.11, pp. 2453-2469, 2023, DOI:10.32604/biocell.2023.030032

    Abstract Introduction: The difficulty in treating lung adenocarcinoma (LUAD) is caused by a shortage of knowledge about the biological mechanisms and a lack of treatment choices. Objectives: The aim of this study was to identify a valuable molecular target for the treatment of LUAD. Methods: Using multiple databases, we screened for hub genes in LUAD using Cytoscape and explored the expression and prognosis of DLG associated protein 5 (DLGAP5) in LUAD. We investigated the genetic variation, functional enrichment, and epigenetic activity of DLGAP5. Furthermore, we evaluated the relationship between the tumor microenvironment (TME) and DLGAP5. Results: Our study identified 10 hub… More > Graphic Abstract

    Analysis of functional hub genes indicates DLGAP5 is linked to lung adenocarcinoma prognosis

  • Open Access

    ARTICLE

    A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures

    JING GUO1, CHANGYONG TONG1, JIANGUANG SHI1, XINJIAN LI1, XUEQIN CHEN2,*

    Oncology Research, Vol.32, No.1, pp. 199-212, 2024, DOI:10.32604/or.2023.030969

    Abstract Oxidative stress (OS) is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy. However, the OS-associated therapeutic target for esophageal squamous cell carcinoma (ESCC) remains unconfirmed. In our study, gene expression data of ESCC and clinical information from public databases were downloaded. Through LASSO-Cox regression analysis, a risk score (RS) signature map of prognosis was constructed and performed external verification with the GSE53625 cohort. The ESTIMATE, xCell, CIBERSORT, TIMER, and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment (IM). Afterward, functional enrichment analysis clarified the underlying mechanism of the model. Nomogram… More >

  • Open Access

    Ring finger protein 157 is a prognostic biomarker and is associated with immune infiltrates in human breast cancer

    XIN ZHU1,2,#, BIN XIAO3,#,*, WENWU ZHANG3,4, XIAOYU SONG3, WEI GONG5, LINHAI LI3,*, XINPING CHEN1,2,*

    BIOCELL, Vol.47, No.10, pp. 2265-2281, 2023, DOI:10.32604/biocell.2023.029195

    Abstract Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitin ligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cell infiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly available datasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Several independent datasets were screened for investigating the relationship between RNF157 and breast cancer survival, different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis to identify signaling pathways associated with… More >

  • Open Access

    ARTICLE

    Novel defined N7-methylguanosine modification-related lncRNAs for predicting the prognosis of laryngeal squamous cell carcinoma

    ZHAOXU YAO*, HAIBIN MA, LIN LIU, QIAN ZHAO, LONGCHAO QIN, XUEYAN REN, CHUANJUN WU, KAILI SUN

    BIOCELL, Vol.47, No.9, pp. 1965-1975, 2023, DOI:10.32604/biocell.2023.030796

    Abstract Objective: Through integrated bioinformatics analysis, the goal of this work was to find new, characterised N7-methylguanosine modification-related long non-coding RNAs (m7G-lncRNAs) that might be used to predict the prognosis of laryngeal squamous cell carcinoma (LSCC). Methods: The clinical data and LSCC gene expression data for the current investigation were initially retrieved from the TCGA database & sanitised. Then, using co-expression analysis of m7G-associated mRNAs & lncRNAs & differential expression analysis (DEA) among LSCC & normal sample categories, we discovered lncRNAs that were connected to m7G. The prognosis prediction model was built for the training category using univariate & multivariate COX… More >

  • Open Access

    ARTICLE

    Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

    GAOZHONG LI, FUXIN LI, NING WEI, QING JIA*

    BIOCELL, Vol.47, No.9, pp. 2081-2099, 2023, DOI:10.32604/biocell.2023.029986

    Abstract Background: This study was aimed at identifying natural killer (NK) cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer (GC) prognosis. Methods: We obtained NK cell-related genes from various databases, followed by Cox regression analysis and molecular typing to identify prognostic genes. Various immune algorithms and enrichment analyses were used to investigate the mutations, immune status, and pathway variations among different genotypes. The key prognostic genes were assessed using the least absolute shrinkage and selection operator (Lasso) regression analysis and univariate Cox regression analysis. Thereafter, the risk score (RS) prognosis model was constructed based… More > Graphic Abstract

    Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

  • Open Access

    ARTICLE

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

    MENGQIN ZHU1,2,3,4,#, TIANYI XU5,#, HAN ZHANG3,4, XIN FAN3,4, YULAN WANG6, JIAJIA ZHANG3,4, FEI YU1,2,3,4,*

    BIOCELL, Vol.47, No.9, pp. 1931-1945, 2023, DOI:10.32604/biocell.2023.028968

    Abstract Glutamine metabolism (GM) plays an important role in tumor growth and proliferation. Skin cutaneous melanoma (SKCM) is a glutamine-dependent cancer. However, the molecular characteristics and action mechanism of GM on SKCM remain unclear. Therefore, we aimed to explore the effects of GM-related genes on survival, clinicopathological characteristics, and the tumor microenvironment in SKCM. In this study, 682 SKCM samples were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus clustering was used to classify SKCM samples into distinct subtypes based on 41 GM-related genes. Differences in survival, immune infiltration, clinical characteristics, and Kyoto Encyclopedia of… More > Graphic Abstract

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

  • Open Access

    ARTICLE

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

    PENGCHENG ZHANG1,#,*, XINGLONG ZHANG2,#, YONGFU ZHU3, YIYI CUI1, JING XU4, WEIPING ZHANG1,*

    Oncology Research, Vol.31, No.6, pp. 937-953, 2023, DOI:10.32604/or.2023.030933

    Abstract Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. However, the role of PLK1 and necroptosis in lung adenocarcinoma (LA) remains unclear. In this study, we analyzed The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression databases to evaluate the prognostic value and mechanistic role of PLK1 in LA. PLK1 was found to be highly expressed in LA and was positively associated with advanced disease staging and poor survival outcomes. Functional enrichment analysis showed that PLK1 was involved in cell mitosis, neurotransmitter transmission, and drug metabolism. Further analysis using single-sample gene set enrichment… More > Graphic Abstract

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

  • Open Access

    ARTICLE

    CHRM3 is a novel prognostic factor of poor prognosis and promotes glioblastoma progression via activation of oncogenic invasive growth factors

    BIN ZHANG1,#, JIANYI ZHAO3,#, YONGZHI WANG2,#, HUA XU1, BO GAO1, GUANGNING ZHANG1, BIN HAN1, GUOHONG SONG1, JUNCHEN ZHANG1,*, WEI MENG1,*

    Oncology Research, Vol.31, No.6, pp. 917-927, 2023, DOI:10.32604/or.2023.030425

    Abstract Glioblastoma (GBM) is the most aggressive cancer of the brain and has a high mortality rate due to the lack of effective treatment strategy. Clarification of molecular mechanisms of GBM’s characteristic invasive growth are urgently needed to improve the poor prognosis. Single-nuclear sequencing of primary and recurrent GBM samples revealed that levels of M3 muscarinic acetylcholine receptor (CHRM3) were significantly higher in the recurrent samples than in the primary samples. Moreover, immunohistochemical staining of an array of GBM samples showed that high levels of CHRM3 correlated with poor prognosis, consistent with The Cancer Genome Atlas database. Knockdown of CHRM3 inhibited… More >

  • Open Access

    ARTICLE

    Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

    Yuki Kawasaki1,*, Takeshi Sasaki1, Daisuke Kobayashi2

    Congenital Heart Disease, Vol.18, No.4, pp. 431-445, 2023, DOI:10.32604/chd.2023.030910

    Abstract Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized that hemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinical features and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients who underwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI  ≥ 3, SVR index (SVRI) ≥ 20; B, CI < 3, SVRI ≥ 20; C, CI ≥ 3, SVRI < 20; and D, CI < 3, SVRI < 20. The primary outcome was freedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant, and death. Clinical and hemodynamic variables and freedom from… More > Graphic Abstract

    Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

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