Wendong Jia^#, Ting Zhang^#, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang^*, Ni Yin^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068651 - 30 December 2025

Abstract Objectives: Chromobox 4 (CBX4), a polycomb protein family member linked to tumor pathogenesis via dysregulation, has an incompletely defined role in gastric cancer (GC). The study aimed to investigate the role and mechanism of CBX4 in GC progression and evaluate its potential as a therapeutic target. Methods: CBX4 expression was assessed in GC tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells. Clinicopathological correlations were analyzed. Functional impacts of CBX4 were determined using knockdown and overexpression models in vitro (cell proliferation, migration, invasion) and in vivo (xenograft tumorigenesis in nude… More >

Xiaopan Zou^1,2, Meiyang Sun³, Xin Jiang¹, Jingze Yu², Xiaomeng Li^4,*, Bingyu Nie^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4157-4157, 2025, DOI:10.32604/or.2025.075991 - 27 November 2025

Abstract This article has no abstract. More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >

David Amilo^1,*, Khadijeh Sadri¹, Evren Hincal^1,2, Mohamed Hafez^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2189-2222, 2025, DOI:10.32604/cmes.2025.070298 - 26 November 2025

Abstract Breast cancer’s heterogeneous progression demands innovative tools for accurate prediction. We present a hybrid framework that integrates machine learning (ML) and fractional-order dynamics to predict tumor growth across diagnostic and temporal scales. On the Wisconsin Diagnostic Breast Cancer dataset, seven ML algorithms were evaluated, with deep neural networks (DNNs) achieving the highest accuracy (97.72%). Key morphological features (area, radius, texture, and concavity) were identified as top malignancy predictors, aligning with clinical intuition. Beyond static classification, we developed a fractional-order dynamical model using Caputo derivatives to capture memory-driven tumor progression. The model revealed clinically interpretable patterns: More >

Sihai Duan^1,2,#, Xiaoyan Li^3,#, Cailu Song³, Song Wu³, Yunyun Tang^3,4, Qing Bao^3,4, Na Li^3,*, Hailin Tang^3,*

Oncology Research, Vol.33, No.11, pp. 3543-3556, 2025, DOI:10.32604/or.2025.068292 - 22 October 2025

Abstract Objectives: Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest prognosis. This study aimed to elucidate the molecular pathways through which isoliquiritigenin (ISL), a natural chalcone compound derived from licorice and other plant roots, targets interferon regulatory factor 5 (IRF5) in TNBC. Methods: TNBC cell lines were cultured and subjected to IRF5 knockdown using short hairpin RNA. Cell proliferation was assessed by cell counting kit-8 (CCK-8) assay and colony formation assays. Western blotting and quantitative reverse transcription polymerase chain reaction (RT-PCR) were employed to measure expression levels of IRF5, solute carrier family… More >

Botao Pan¹, Zirun Luo², Xiujuan Yang¹, Qingqing Liu³, Zhimin Yang^4,*, Chenglai Xia^1,3,*

Oncology Research, Vol.33, No.11, pp. 3557-3582, 2025, DOI:10.32604/or.2025.068119 - 22 October 2025

Abstract Objectives: Breast cancer is characterized by significant metabolic dysregulation, in which altered enzyme activity plays a central role. Malate dehydrogenase 2 (MDH2), a key enzyme in the tricarboxylic acid cycle, has been implicated in several malignancies, but its role in breast cancer tumorigenesis and progression remains unclear. We aimed to elucidate the oncogenic role of MDH2 in breast cancer and to evaluate its potential as a diagnostic, therapeutic, and prognostic biomarker. Methods: We combined in vitro cell-based assays with mouse xenograft models to systematically dissect how MDH2 governs breast cancer growth. In vitro, we assessed the effects… More >

Ying Fang^1,2,3,#, Anqi Wu^2,4,#, Yu-Sheng Cong^5,*, Guoqing Li^1,2,*

Oncology Research, Vol.33, No.11, pp. 3231-3245, 2025, DOI:10.32604/or.2025.066402 - 22 October 2025

Abstract Gastric Cancer (GC) is a highly prevalent and poorly prognostic gastrointestinal malignancy with low overall treatment efficacy worldwide. Early diagnostic markers and potential therapeutic targets for GC treatment are urgently needed. UFMylation, a novel ubiquitin-like modification is indispensable for numerous fundamental cellular processes. Deficiency in this modification is reported to be associated with several human diseases including cancer. Accumulating evidence suggests that the expression of the key UFMylation components is closely associated with GC cell proliferation, invasion, metastasis, and chemotherapy resistance. Recent clinical studies have further highlighted the prognostic value and therapeutic potential of UFMylation More >

Yun Zhou^1,2, Shixiong Liu^1,2, Ya Zheng^1,3,4, Yuping Wang^1,3,4,*, Yongning Zhou^1,3,4,*

BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

Hong Wu, Yang Liu^*

BIOCELL, Vol.49, No.10, pp. 1985-2006, 2025, DOI:10.32604/biocell.2025.069527 - 22 October 2025

Abstract Background: Acute pancreatitis (AP) is a serious gastrointestinal disorder. Tetramethylpyrazine (TMP), a bioactive alkaloid extracted from Ligusticum chuanxiong, exhibits various pharmacological effects, but its protective mechanisms against AP remain unclear. This study aimed to investigate the protective effects and underlying mechanisms of TMP in AP. Methods: The study utilized Cerulein (CER) to model pancreatitis across experimental systems. Cellular responses were characterized through functional assays (CCK-8 viability, EdU proliferation, Transwell migration, flow cytometric apoptosis, Fluo-3/AM calcium imaging) and inflammatory profiling (ELISA for trypsin, CRP, TNF-α, IL-1β, IL-6). Autophagy was monitored via mRFP-GFP-LC3 flux and LysoTracker staining, with… More > Graphic Abstract