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  • Open Access

    ARTICLE

    Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways: An in vivo and a network pharmacology assessment

    LINGYAN LV1,2,#, JING ZHAO1,2,#, XUAN WANG1,2, LIUYAN XU1,2, YINGYI FAN2, CHUNHUI WANG3, HONGQIAO FAN4,5,*, XIAOHUA PEI5,*

    BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

    Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

  • Open Access

    ARTICLE

    CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway

    WEI DU1, FANG YIN1, YATING ZHONG1, MINJIE LUO1, ZHEN WANG2, PENG LIN2, QING LIU2,*, HAN YANG2,*

    Oncology Research, Vol.31, No.6, pp. 929-936, 2023, DOI:10.32604/or.2023.030611

    Abstract Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the treatment of NSCLC, circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues. RNA was isolated and used for circRNA sequencing. Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC, including their functions in cell proliferation and migration. How circRNAs function in NSCLC was explored… More > Graphic Abstract

    CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway

  • Open Access

    ARTICLE

    The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma

    RUI ZHANG1,2,#, PENG ZHOU1,3,#, XIA OU4, PEIZHU ZHAO2, XIJING GUO2, MIAN XI5,*, CHEN QING1,*

    Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184

    Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in ESCC. Additionally, suppression of DMRTA1… More >

  • Open Access

    ARTICLE

    CHRM3 is a novel prognostic factor of poor prognosis and promotes glioblastoma progression via activation of oncogenic invasive growth factors

    BIN ZHANG1,#, JIANYI ZHAO3,#, YONGZHI WANG2,#, HUA XU1, BO GAO1, GUANGNING ZHANG1, BIN HAN1, GUOHONG SONG1, JUNCHEN ZHANG1,*, WEI MENG1,*

    Oncology Research, Vol.31, No.6, pp. 917-927, 2023, DOI:10.32604/or.2023.030425

    Abstract Glioblastoma (GBM) is the most aggressive cancer of the brain and has a high mortality rate due to the lack of effective treatment strategy. Clarification of molecular mechanisms of GBM’s characteristic invasive growth are urgently needed to improve the poor prognosis. Single-nuclear sequencing of primary and recurrent GBM samples revealed that levels of M3 muscarinic acetylcholine receptor (CHRM3) were significantly higher in the recurrent samples than in the primary samples. Moreover, immunohistochemical staining of an array of GBM samples showed that high levels of CHRM3 correlated with poor prognosis, consistent with The Cancer Genome Atlas database. Knockdown of CHRM3 inhibited… More >

  • Open Access

    REVIEW

    The role of mesenchymal stem cell-derived exosomes in tumor progression

    CARL RANDALL HARREL1, VALENTIN DJONOV2, ANA VOLAREVIC3, DRAGICA PAVLOVIC4, VLADISLAV VOLAREVIC4,5,*

    BIOCELL, Vol.47, No.8, pp. 1757-1769, 2023, DOI:10.32604/biocell.2023.028567

    Abstract Exosomes derived from mesenchymal stem cells (MSC-Exos) are nano-sized extracellular vesicles enriched with bioactive molecules, such as microRNAs, enzymes, cytokines, chemokines, immunomodulatory, trophic, and growth factors. These molecules regulate the survival, phenotype, and function of malignant and tumor-infiltrated immune cells. Due to their nano-size and bilayer lipid envelope, MSC-Exos can easily bypass biological barriers and may serve as drug carriers to deliver chemotherapeutics directly into the tumor cells. Here, we summarize current knowledge regarding molecular mechanisms responsible for MSC-Exos-dependent modulation of tumor progression and discuss insights regarding the therapeutic potential of MSC-Exos in the treatment of malignant diseases. More > Graphic Abstract

    The role of mesenchymal stem cell-derived exosomes in tumor progression

  • Open Access

    ARTICLE

    Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway

    TIANYING CAI1,2, JUNJIE BAI1, PENG TAN3, ZHIWEI HUANG1, CHEN LIU1, ZIMING WU1, YONGLANG CHENG1, TONGXI LI1, YIFAN CHEN1, JIAN RUAN4, LIN GAO5, YICHAO DU3,*, WENGUANG FU1,3,*

    Oncology Research, Vol.31, No.5, pp. 805-817, 2023, DOI:10.32604/or.2023.029549

    Abstract Hepatocellular carcinoma (HCC) is a common malignancy that is driven by multiple genes and pathways. The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). Furthermore, the change in the expression levels of ZYX also altered that of proteins related to cell… More >

  • Open Access

    ARTICLE

    mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance

    CHIWEN BU1,2, LIGANG ZHAO1, LISHAN WANG1, ZEQIAN YU1, JIAHUA ZHOU1,*

    Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309

    Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the mTORC2 obligate subunit Rictor sensitized… More > Graphic Abstract

    mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance

  • Open Access

    ARTICLE

    The SMAD2/miR-4256/HDAC5/p16INK4a signaling axis contributes to gastric cancer progression

    MIN WANG1,#, HAILIANG ZHAO1,2,#, WEIWEI CHEN3,#, CAIQUN BIE4,#, JINYING YANG1, WENRUI CAI1, CHUTIAN WU1, YANFANG CHEN1, SHUFEN FENG1, YING SHI1, YUTING LI1, HUIJUN TANG4, LIXIAN ZHONG1, LILIANGZI GUO1, SISI CHEN1, LINJING LONG5, SHAOHUI TANG1,*

    Oncology Research, Vol.31, No.4, pp. 515-541, 2023, DOI:10.32604/or.2023.029101

    Abstract The dysregulation of exosomal microRNAs (miRNAs) plays a crucial role in the development and progression of cancer. This study investigated the role of a newly identified serum exosomal miRNA miR-4256 in gastric cancer (GC) and the underlying mechanisms. The differentially expressed miRNAs were firstly identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics. Next, the expression of serum exosomal miR-4256 was analyzed in GC cells and GC tissues, and the role of miR-4256 in GC was investigated by in vitro and in vivo experiments. Then, the effect of miR-4256 on its downstream target genes… More > Graphic Abstract

    The SMAD2/miR-4256/HDAC5/p16<sup>INK4a</sup> signaling axis contributes to gastric cancer progression

  • Open Access

    ARTICLE

    Betulinic acid-mediating miRNA-365 inhibited the progression of pancreatic cancer

    XIN LI1,2,#, WENKAI JIANG3,#, WANCHENG LI3,#, SHI DONG3, YAN DU3, HUI ZHANG1,*, WENCE ZHOU1,3,*

    Oncology Research, Vol.31, No.4, pp. 505-514, 2023, DOI:10.32604/or.2023.026959

    Abstract Background: The dilemma of pancreatic cancer treatment has become a global challenge. For this reason, effective, feasible, and new medical methods are currently much-needed. Betulinic acid (BA) has been valued as a potential therapy for pancreatic cancer. However, the mechanism by which BA exerts an inhibitory effect on the development of pancreatic cancer remains elusive. Methods: A rat model and two cell models of pancreatic cancer were established, and the effect of BA on pancreatic cancer was verified in vivo and in vitro by using MTT, Transwell, flow cytometry, RT-PCR, Elisa and immunohistochemistry. At the same time, miR-365 inhibitors were… More > Graphic Abstract

    Betulinic acid-mediating miRNA-365 inhibited the progression of pancreatic cancer

  • Open Access

    ARTICLE

    Detection of Alzheimer’s Disease Progression Using Integrated Deep Learning Approaches

    Jayashree Shetty1, Nisha P. Shetty1,*, Hrushikesh Kothikar1, Saleh Mowla1, Aiswarya Anand1, Veeraj Hegde2

    Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1345-1362, 2023, DOI:10.32604/iasc.2023.039206

    Abstract Alzheimer’s disease (AD) is an intensifying disorder that causes brain cells to degenerate early and destruct. Mild cognitive impairment (MCI) is one of the early signs of AD that interferes with people’s regular functioning and daily activities. The proposed work includes a deep learning approach with a multimodal recurrent neural network (RNN) to predict whether MCI leads to Alzheimer’s or not. The gated recurrent unit (GRU) RNN classifier is trained using individual and correlated features. Feature vectors are concatenated based on their correlation strength to improve prediction results. The feature vectors generated are given as the input to multiple different… More >

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