Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (164)
  • Open Access

    ARTICLE

    Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway

    TIANYING CAI1,2, JUNJIE BAI1, PENG TAN3, ZHIWEI HUANG1, CHEN LIU1, ZIMING WU1, YONGLANG CHENG1, TONGXI LI1, YIFAN CHEN1, JIAN RUAN4, LIN GAO5, YICHAO DU3,*, WENGUANG FU1,3,*

    Oncology Research, Vol.31, No.5, pp. 805-817, 2023, DOI:10.32604/or.2023.029549

    Abstract Hepatocellular carcinoma (HCC) is a common malignancy that is driven by multiple genes and pathways. The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). Furthermore, the change in the expression levels of ZYX also altered that of proteins related to cell… More >

  • Open Access

    ARTICLE

    Comprehensive bioinformatics analysis and experimental validation: An anoikis-related gene prognostic model for targeted drug development in head and neck squamous cell carcinoma

    LIN QIU1,#, ANQI TAO1,#, XIAOQIAN SUN4,5, FEI LIU1, XIANPENG GE2,3,*, CUIYING LI1,*

    Oncology Research, Vol.31, No.5, pp. 715-752, 2023, DOI:10.32604/or.2023.029443

    Abstract We analyzed RNA-sequencing (RNA-seq) and clinical data from head and neck squamous cell carcinoma (HNSCC) patients in The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal to investigate the prognostic value of anoikis-related genes (ARGs) in HNSCC and develop new targeted drugs. Differentially expressed ARGs were screened using bioinformatics methods; subsequently, a prognostic model including three ARGs (CDKN2A, BIRC5, and PLAU) was constructed. Our results showed that the model-based risk score was a good prognostic indicator, and the potential of the three ARGs in HNSCC prognosis was validated by the TISCH database, the model’s accuracy was validated in two… More >

  • Open Access

    ARTICLE

    YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells

    JUNYU HE1,2,3, FENG ZENG1,2,3, XI JIN1,2,3, LIN LIANG1,2,3, MENGXIANG GAO1,2,3, WENTAO LI1,2,3, GUIYUAN LI1,2,3, YANHONG ZHOU1,2,3,*

    Oncology Research, Vol.31, No.4, pp. 615-630, 2023, DOI:10.32604/or.2023.029698

    Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. However, the detailed mechanism of Fra-1 in GC is unclear, such as the identification of Fra-1-interacting proteins and their role in GC pathogenesis. In this study, we identified tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH) as a Fra-1-interacting protein in GC cells using co-immunoprecipitation… More >

  • Open Access

    ARTICLE

    LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral squamous carcinoma

    FAYU SHAN1, LANLAN LIANG1, CHONG FENG1, HONGBAO XU1, ZIROU WANG1, WEILI LIU1, LINGLING PU1, ZHAOLI CHEN1, GANG CHEN2,*, XINXING WANG1,*

    Oncology Research, Vol.31, No.4, pp. 481-493, 2023, DOI:10.32604/or.2023.029064

    Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently, Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; however, how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored. This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC. Methods: To explore the mechanism by which LAMC2 is highly expressed in OSCC, we used small interfering RNA (siRNA) to knock down LAMC2 to further observe the changes in the… More >

  • Open Access

    ARTICLE

    PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A

    YU LU1, TSUTOMU MIYAMOTO1,*, HODAKA TAKEUCHI1, FUMI TSUNODA1, NAOKI TANAKA2,3,4, TANRI SHIOZAWA1

    Oncology Research, Vol.31, No.3, pp. 239-253, 2023, DOI:10.32604/or.2023.026067

    Abstract Endometrial carcinoma (EMC) is associated with obesity; however, the underlying mechanisms have not yet been elucidated. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that is involved in lipid, glucose, and energy metabolism. PPARα reportedly functions as a tumor suppressor through its effects on lipid metabolism; however, the involvement of PPARα in the development of EMC remains unclear. The present study demonstrated that the immunohistochemical expression of nuclear PPARα was lower in EMC than in normal endometrial tissues, suggesting the tumor suppressive nature of PPARα. A treatment with the PPARα activator, irbesartan, inhibited the EMC cell lines, Ishikawa and… More >

  • Open Access

    ARTICLE

    Vitamin D attenuates TGF-β1-induced lung fibroblast proliferation and migration through repression of RasGRP3

    GUANQIONG HU1, RISHENG HUANG2, LUELUE LU1, QINSHI PAN3, XIAOXIN CHEN1,*

    BIOCELL, Vol.47, No.6, pp. 1243-1251, 2023, DOI:10.32604/biocell.2023.027763

    Abstract Background: Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that plays a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). While previous studies have revealed a cross-talk between vitamin D and TGF-β1 signaling, it is still unclear how they interact with each other to regulate the progression of IPF. Methods: In this work, we searched for a novel mediator of TGF-β1 activity in lung fibroblasts and examined its regulation by vitamin D. In addition, we investigated the mechanism underlying the interaction between vitamin D and TGF-β1 signaling in lung fibroblast activation. Bioinformatic analysis was performed to identify TGF-β1… More >

  • Open Access

    ARTICLE

    LINC00609 inhibits A549 cells progression through the regulation of miR-128-3p/RND3 axis

    XIANGCHAO DING1,#, YANG ZHAO2,#, XINGHUA ZHANG1, HUIQING LIN1,*

    BIOCELL, Vol.47, No.5, pp. 1117-1126, 2023, DOI:10.32604/biocell.2023.026715

    Abstract Background: Long-chain non-coding RNA (lncRNA) LINC00609 is a potential tumor suppressor, but the mechanism of action in non-small cell lung cancer (NSCLC) is yet to be understood.Objectives: The effects of LINC00609 on A549 cell proliferation, apoptosis, and cell cycle arrest were investigated. Methods: The LINC00609 levels in NSCLC and normal tissues were analyzed by bioinformatics. Expressions of LINC00609, miR-128-3p, and Rho family GTPase 3 (RND3) in NSCLC cells (A549) were determined by qRT-PCR. Bioinformatics analysis predicted target genes and dual-luciferase reporter assays to ensure that LINC00609 targeted miR-128-3p and miR-128-3p targeted RND3. The proliferation of cells was determined using EDU… More >

  • Open Access

    ARTICLE

    UCK2 promotes the proliferation, migration, and invasion of trophoblast cells in preeclampsia by activating the STAT3 pathway

    WEI XIA1, NING YANG2, XIAOYAN FENG3, TING XIN1, YONGLE JING1, YUMING LI4,*, CHENGZHI LU1,5,*

    BIOCELL, Vol.47, No.4, pp. 837-847, 2023, DOI:10.32604/biocell.2023.026161

    Abstract Background: Preeclampsia (PE), characterized by hypertension and proteinuria, leads to serious maternal and infant complications. Uridine-cytidine kinase 2 (UCK2) belongs to the UCK family, a class of enzymes that catalyzes the conversion of uridine and cytidine to monophosphate form. However, the role of UCK2 in PE has not been reported. Methods: The expression of UCK2 was detected in the placenta of PE patients and N(ω)-nitro-L-arginine methyl esterinduced PE mouse model. Through forced up-regulation or down-regulation of UCK2 in vitro, we examined the effects of UCK2 on the proliferation, apoptosis, migration, and invasion of trophoblast cells. Stattic, the inhibitor of STAT3… More >

  • Open Access

    ARTICLE

    Semaphorin 7A promotes human vascular smooth muscle cell proliferation and migration through the β-catenin signaling pathway

    XIAOSU SONG, FEN GAO, HONG LI, WEIWEI QIN, CHANJUAN CHAI, GUOJUAN SHI, HUIYU YANG*

    BIOCELL, Vol.47, No.4, pp. 849-858, 2023, DOI:10.32604/biocell.2023.026545

    Abstract Background: Vascular smooth muscle cells (VSMCs) undergo a conversion from a contractile phenotype to a proliferative synthetic phenotype, contributing to the pathogenesis of cardiovascular diseases. Semaphorin 7A (SEMA7A) is a glycosylphosphatidylinositol-anchored membrane protein that plays an important role in vascular homeostasis by regulating endothelial cell behaviors. However, the expression and role of SEMA7A in VSMCs remain unclear.Methods: In this study, we screened for VSMC-regulating genes in publicly available datasets and analyzed the expression of SEMA7A in human coronary artery smooth muscle cells (hCASMCs) treated with platelet-derived growth factor-BB (PDGF-BB). The effects of SEMA7A overexpression and knockdown on hCASMC proliferation and… More >

  • Open Access

    ARTICLE

    Single-cell sequencing analysis reveals the molecular mechanism of promotion of SCAP proliferation upon AZD2858 treatment

    YIFAN XU1,#, DONGMEI CHENG1,#, LEI HU1, XIN DONG2, LIYING LV2, CHEN ZHANG2, JIAN ZHOU1,3,4,*

    BIOCELL, Vol.47, No.4, pp. 825-836, 2023, DOI:10.32604/biocell.2023.026122

    Abstract The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation. Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway, yet the function of this pathway in tooth regeneration remains unclear. Here, we found that AZD2858 promotes the accumulation of β-catenin in the nuclei of stem cells from the apical papilla (SCAPs) and enhances cell proliferation. Single-cell sequencing was performed on SCAPs treated with AZD2858. Eight clusters were identified, namely SCAPs-CNTNAP2, SCAPs-DTL, SCAPs-MYH11, SCAPs-MKI67, SCAPs-CXCL8, SCAPs-TPM2, SCAPs-IFIT2 and SCAPs-NEK10. The pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11, SCAPs-CNTNAPs and… More >

Displaying 21-30 on page 3 of 164. Per Page