Md Shakhawat Hossain^1,2,#,*, Md Sahilur Rahman^2,#, Munim Ahmed², Anowar Hussen³, Zahid Ullah⁴, Mona Jamjoom⁵

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3193-3215, 2025, DOI:10.32604/cmc.2025.065230 - 03 July 2025

Abstract One in every eight men in the US is diagnosed with prostate cancer, making it the most common cancer in men. Gleason grading is one of the most essential diagnostic and prognostic factors for planning the treatment of prostate cancer patients. Traditionally, urological pathologists perform the grading by scoring the morphological pattern, known as the Gleason pattern, in histopathology images. However, this manual grading is highly subjective, suffers intra- and inter-pathologist variability and lacks reproducibility. An automated grading system could be more efficient, with no subjectivity and higher accuracy and reproducibility. Automated methods presented previously… More >

Mostafa Ahmed Arafa^1,2, Karim Hamda Farhat^1,*, Nesma Lotfy³, Farrukh Kamel Khan¹, Alaa Mokhtar⁴, Abdulaziz Mohammed Althunayan¹, Waleed Al-Taweel⁴, Sultan Saud Al-Khateeb⁴, Sami Azhari^1,5, Danny Munther Rabah^1,4

Canadian Journal of Urology, Vol.32, No.3, pp. 173-180, 2025, DOI:10.32604/cju.2025.066016 - 27 June 2025

Abstract Background: Transrectal (TR) and transperineal (TP) biopsies are commonly used methods for diagnosing prostate cancer. However, their comparative effectiveness in conjunction with machine learning (ML) techniques remains underexplored. This study aimed to evaluate the predictive accuracy of ML algorithms in detecting prostate cancer using data derived from TR and TP biopsies. Methods: The clinical records of patients who underwent prostate biopsy at King Saud University Medical City and King Faisal Specialist Hospital and Research Centerin Riyadh, Saudi Arabia, between 2018 and 2025 were analyzed. Data were used to train and test ML models, including eXtreme… More >

Ryan Daigle¹, Ilene Staff², Joseph Tortora², Tara McLaughlin Proto^3,*, Kevin Pinto³, Rosa Negron², Jonathan Earle⁴, Joseph Wagner,³

Canadian Journal of Urology, Vol.32, No.3, pp. 189-198, 2025, DOI:10.32604/cju.2025.063773 - 27 June 2025

Abstract Introduction: We examined the pathology and safety outcomes associated with the extent of pelvic lymph node dissection in patients with high-risk prostate cancer undergoing radical prostatectomy. Materials and Methods: We retrospectively identified men with prostate cancer who underwent robot-assisted radical prostatectomy with pelvic lymph node dissection between May 2016 and September 2021. Cases were categorized using Current Procedural Terminology (CPT) codes (38571) for extended lymph node dissection and super-extended lymph node dissection (38572). Using logistic regression, we compared the groups on a number of factors, including recurrence. Results: Super-extended lymph node dissection had significantly higher median… More >

Zachariah Taylor^1,*, Kayla Meyer², Danielle Terrenzio², Ryan Wong³, Sharon Larson⁴, Stephanie Kjelstrom⁴, Natalina Contoreggi⁵, Laurence Belkoff^1,6, Ilia Zeltser^1,6

Canadian Journal of Urology, Vol.32, No.1, pp. 21-27, 2025, DOI:10.32604/cju.2025.064705 - 20 March 2025

Abstract Purpose: While the mental health impact of a prostate cancer diagnosis, including low-risk prostate cancer, is well-documented, the effect of pre-existing anxiety and/or depression on adherence to active surveillance protocols in low-risk prostate cancer patients remains unclear. This study assessed the association between prior anxiety and/or depression and active surveillance adherence in men with low-risk prostate cancer. Methods: We conducted a retrospective, multicenter study involving 426 men diagnosed with low-risk prostate cancer who were recommended active surveillance as the primary management strategy. Active surveillance adherence was defined by completion of both a prostate-specific antigen test… More >

RIYAD F. ALZHRANI¹, LAMA BINOBAID², ABDULAZIZ A. ALORAINI¹, MESHAL S. ALSAHLI¹, AHMED H. BAKHEIT³, HANADI H. ASIRI³, SABRY M. ATTIA², ALI ALHOSHANI², GAMALELDIN I. HARISA^1,*

Oncology Research, Vol.33, No.4, pp. 919-935, 2025, DOI:10.32604/or.2024.054537 - 19 March 2025

Abstract Objective: Prostate cancer (PCA) is the second most widespread cancer among men globally, with a rising mortality rate. Enzyme-responsive lipid nanoparticles (ERLNs) are promising vectors for the selective delivery of anticancer agents to tumor cells. The goal of this study is to fabricate ERLNs for dual delivery of gefitinib (GF) and simvastatin (SV) to PCA cells. Methods: ERLNs loaded with GF and SV (ERLNGFSV) were assembled using bottom-up and top-down techniques. Subsequently, these ERLN cargoes were coated with triacylglycerol, and phospholipids and capped with chitosan (CS). The ERLNGFSV, and CS engineered ERLNGFSV (CERLNGFSV) formulations were… More > Graphic Abstract

XIUWANG WEI¹, JIANBO LIANG¹, HUANWEN HUANG¹, DAMING YANG¹, XINXIN WANG¹, XIUJIA WANG¹, CHANGSHENG CHEN¹, KAIQIANG LI¹, TAISEN PANG¹, BIN HU¹, FENGNING WU^2,*

Oncology Research, Vol.33, No.1, pp. 161-169, 2025, DOI:10.32604/or.2024.048054 - 20 December 2024

Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >

Noam Bar-Yaakov^1,2, Ziv Savin^1,2, Ibrahim Fahoum^2,3, Sophie Barnes^2,4, Yuval Bar-Yosef^1,2, Ofer Yossepowitch^1,2, Gal Keren-Paz^1,2, Roy Mano^1,2

Canadian Journal of Urology, Vol.31, No.1, pp. 11793-11801, 2024

Abstract Introduction: Prostate cancer screening with PSA is associated with low specificity; furthermore, little is known about the optimal timing of biopsy. We aimed to evaluate whether a risk classification system combining PSA density (PSAD) and mpMRI can predict clinically significant cancer and determine biopsy timing.
Materials and methods: We reviewed the medical records of 256 men with a PI-RADS ≥ 3 lesion on mpMRI who underwent transperineal targeted and systematic biopsies of the prostate between 2017-2019. Patients were stratified into three risk groups based on PSAD and mpMRI findings.
The study endpoint was clinically significant prostate cancer (CSPC).… More >

Ioana Fugaru¹, David Bouhadana¹, Gautier Marcq^2,3, Joseph Moryousef⁴, Alexis Rompré-Brodeur¹, Andrew Meng⁴, Oleg Loutochin¹, George Loutochin¹, Maurice Anidjar¹, Frank Bladou⁵, Rafael Sanchez-Salas¹

Canadian Journal of Urology, Vol.31, No.1, pp. 11784-11793, 2024

Abstract Introduction: Partial gland ablation (PGA) using high intensity focal ultrasound (HIFU) is an alternative to active surveillance for low to intermediate risk localized prostate cancer. This pilot study assessed quality of life (QoL) outcomes during the implementation of PGA HIFU at our institution.
Materials and methods: We prospectively enrolled 25 men with a diagnosis of localized low/intermediate risk prostate cancer who elected to undergo PGA-HIFU in a pilot study at our institution between 2013 and 2016. Patients underwent pre-treatment mpMRI and transrectal ultrasound-guided biopsies. The primary endpoints were impact on patient-reported functional outcomes (erectile, urinary function, QoL)… More >

Alex J. Xu¹, Sameer Thakker², Vyom Sawhney², Rozalba Gogaj¹, Fjolla Vokshi¹, James S. Wysock¹

Canadian Journal of Urology, Vol.31, No.1, pp. 11767-11774, 2024

Abstract Introduction: We evaluate the rate of developing ciprofloxacin resistance in patients undergoing repeat prostate biopsies (PBx), associated risk factors, and impact on complications.
Materials and methods: We retrospectively evaluated pre-procedural rectal culture (RCx) data in men undergoing PBx from 1/1/2016 to 1/15/2021. Univariate and multivariate logistic regression were utilized to identify risk factors associated with development of antibiotic resistance. Complication rates were compared between ciprofloxacin-sensitive and ciprofloxacin resistant patients.
Results: A total of 743 men underwent initial RCx. Initial RCx detected ciprofloxacin resistance in 22% of patients. A history of diabetes (p = 0.01), > 2 prior prostate… More >

Michelle K. Li, Orlando Diaz, Jonathan E. Katz

Canadian Journal of Urology, Vol.31, No.2, pp. 11861-11863, 2024

Abstract Standard treatment approaches for localized prostate cancer remain limited to active surveillance, radiotherapy, and radical prostatectomy. We present a case of transition zone prostate cancer that was treated with holmium laser enucleation of the prostate, a procedure that is normally reserved for the management of benign prostatic hyperplasia. More >