Amin Einipour¹, Mohammad Mosleh^{1, *}, Karim Ansari-Asl^{1, 2}

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.1, pp. 377-397, 2020, DOI:10.32604/cmes.2020.08496

Abstract The emergence of single-cell RNA-sequencing (scRNA-seq) technology has introduced new information about the structure of cells, diseases, and their associated biological factors. One of the main uses of scRNA-seq is identifying cell populations, which sometimes leads to the detection of rare cell populations. However, the new method is still in its infancy and with its advantages comes computational challenges that are just beginning to address. An important tool in the analysis is dimensionality reduction, which transforms high dimensional data into a meaningful reduced subspace. The technique allows noise removal, visualization and compression of high-dimensional data. This paper presents a new… More >

Jesus Sebastian DISTEL¹, Walter BERON¹, Rodolfo Matias ORTIZ FLORES^1,2

BIOCELL, Vol.43, No.1, pp. 1-6, 2019, DOI:10.32604/biocell.2019.07021

Abstract Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever. In this brief review, we describe how recently described mechanisms help our understanding of C. burnetii invasion and its survival in the host cell by the formation of a replicative niche: the Coxiella-containing vacuole. We describe the actin-associated proteins involved in the internalization of C. burnetii, and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole. More >

Daguo Wang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.91, No.4, pp. 289-312, 2013, DOI:10.3970/cmes.2013.091.289

Abstract A 2-D time-domain numerical coupled model for non-linear wave forces acting on a fixed ship is developed in the present study. The whole domain is divided into the inner domain and the outer domain. The inner domain is the area around the ship section and the flow is described by the Laplace equation. The remaining area is the outer domain and the flow is defined by the higher-order Boussinesq equations in order to consider the nonlinearity of the wave motions. The matching conditions on the interfaces between the inner domain and the outer domain are the continuation of volume flux… More >

Alfredo Nicolás¹, Blanca Bermúdez², Elsa Báez³

CMES-Computer Modeling in Engineering & Sciences, Vol.48, No.1, pp. 83-106, 2009, DOI:10.3970/cmes.2009.048.083

Abstract Numerical results of natural convection flows in two-dimensional cavities, filled with air, are presented to study the effects on the characteristics of the flows as some parameters vary: the Rayleigh number Ra and the aspect ratio A of the cavity. This kind of thermal flows may be modeled by the unsteady Boussinesq approximation in stream function-vorticity variables. The results are obtained with a simple numerical scheme, previously reported for isothermal/mixed convection flows, based mainly on a fixed point iterative process applied to the non-linear elliptic system that results after time discretization. The evolution of the flows, mainly flows converging to… More >

Y.Y. Shan¹, C. Shu^1,2, Z.L. Lu³

CMES-Computer Modeling in Engineering & Sciences, Vol.25, No.2, pp. 99-114, 2008, DOI:10.3970/cmes.2008.025.099

Abstract The local multiquadric-based differential quadrature (MQ-DQ) method proposed by [Shu, Ding, and Yeo (2003)] is a natural mesh-free approach for derivative approximation, which is easy to be implemented to solve problems with curved boundary. Previously, it has been well tested for the two-dimensional (2D) case. In this work, this mesh-free method was extended to simulate fluid flow problems with curved boundary in three-dimensional (3D) space. The main concern of this work is to numerically study the performance of the 3D local MQ-DQ method and demonstrate its capability and flexibility for simulation of 3D incompressible fluid flows with curved boundary. Fractional… More >

D.L. Young^1,3, C.S. Chen², T.K. Wong³

CMC-Computers, Materials & Continua, Vol.2, No.4, pp. 267-276, 2005, DOI:10.3970/cmc.2005.002.267

Abstract A meshless time domain numerical method based on the radial basis functions using multiquadrics (MQ) is employed to simulate electromagnetic field problems by directly solving the time-varying Maxwell's equations without transforming to simplified versions of the wave or Helmholtz equations. In contrast to the conventional numerical schemes used in the computational electromagnetism such as FDTD, FETD or BEM, the MQ method is a truly meshless method such that no mesh generation is required. It is also easy to deal with the appropriate partial derivatives, divergences, curls, gradients, or integrals like semi-analytic solutions. For illustration purposes, the MQ method is employed… More >