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  • Open Access


    Role of RIPK1 in the pathogenesis of acute respiratory distress syndrome


    BIOCELL, Vol.47, No.10, pp. 2151-2162, 2023, DOI:10.32604/biocell.2023.030570

    Abstract Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused by microbial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammation in the lungs and increased alveolar permeability, leading to pulmonary edema and consequently, a low oxygen supply or hypoxemia. ARDS is responsible for 1 in 10 admissions to intensive care units, and the mortality rate for patients with severe ARDS is as high as 46%. Extensive efforts have been devoted to investigating the pathological mechanisms of ARDS to develop new effective clinical strategies. Recent studies have More > Graphic Abstract

    Role of RIPK1 in the pathogenesis of acute respiratory distress syndrome

  • Open Access


    Cylindromatosis Is Required for Survival of a Subset of Melanoma

    Ting La*†, Lei Jin*‡, Xiao Ying Liu*, Ze Hua Song*, Margaret Farrelly, Yu Chen Feng, Xu Guang Yan, Yuan Yuan Zhang*,† Rick F. Thorne*,*§ Xu Dong Zhang*†, Liu Teng*

    Oncology Research, Vol.28, No.4, pp. 385-398, 2020, DOI:10.3727/096504020X15861709922491

    Abstract The deubiquitinase cylindromatosis (CYLD) functions as a tumor suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although short hairpin RNA (shRNA) knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in… More >

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