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  • Open Access

    ARTICLE

    Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways

    WANTONG LIU1,#, DANYANG CHEN1,#, JINGYAO SU1,#, RUILIN ZHENG1,#, RAN KONG1, BING ZHU1, HAO DONG2,*, YINGHUA LI1,*

    BIOCELL, Vol.47, No.1, pp. 187-194, 2023, DOI:10.32604/biocell.2022.023030 - 26 September 2022

    Abstract Liver cancer is the seventh most common malignant tumor in the world and is the second highest cause of death due to cancer. Quercetin, a flavonoid with low toxicity, widely exists in various fruits and vegetables. It has the potential to be a therapeutic agent against various cancers. This study aimed to demonstrate the anti-tumor effect of quercetin on HepG2 cells. Quercetin suppressed the HepG2 cell proliferation in a dose-dependent manner in cell viability assay. Induction of cell apoptosis was confirmed by apoptotic cells population (sub-G1 peak) detected by flow cytometer. A decrease in mitochondrial More >

  • Open Access

    ARTICLE

    Nitric oxide alleviates cadmium-impeded growth by limiting ROS accumulation in pea seedlings

    EKHLAQUE A. KHAN1,2,*, HAMDINO M. I. AHMED3, MEENA MISRA1, PALLAVI SHARMA1,4, AMARENDRA N. MISRA1,5, MIRZA HASANUZZAMAN6,*

    BIOCELL, Vol.46, No.12, pp. 2583-2593, 2022, DOI:10.32604/biocell.2022.021732 - 10 August 2022

    Abstract

    Cadmium (Cd) causes oxidative stress, which leads to the oxidation of various biomolecules by the production of reactive oxygen species (ROS) to facilitate programmed cell death (PCD). The antioxidant defense system fails to detoxify ROS when it is produced in excess. Nitric oxide (NO), a gaseous free radical and a phytohormone, regulates various physiological processes of plants. Therefore, this work was undertaken to study the effects of the application of exogenous sodium nitroprusside (SNP, a NO donor) on growth parameters, oxidative stress, accumulation of secondary metabolites, and activities of antioxidant enzymes under Cd stress. Mild (50

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  • Open Access

    ARTICLE

    Organic Amendments Improve Plant Morpho-Physiology and Antioxidant Metabolism in Mitigating Drought Stress in Bread Wheat (Triticum aestivum L.)

    Taufika Islam Anee1,#, Md. Nur Nabi Islam1,#, Mohamed M. Hassan2, Abdul Awal Chowdhury Masud1, Md. Mahabub Alam1, Mirza Hasanuzzaman1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 1959-1972, 2022, DOI:10.32604/phyton.2022.021137 - 13 May 2022

    Abstract Due to the unpredictable climate change, drought stress is being considered as one of the major threats to crop production. Wheat (Triticum aestivum L. cv. BARI Gom-26) being a dry season crop frequently faces scarcity of water and results in a lower yield. Therefore, this experiment aims to explore the role of different organic amendments (OAs) in mitigating drought stress-induced damage. The pot experiment consisted of different organic amendments viz. compost, vermicompost and poultry manure @0.09 kg m−2 soil, biochar @2.5% w/w soil and chitosan @1% w/w soil which was imposed on the plants grown under both… More >

  • Open Access

    REVIEW

    Role of Reactive Oxygen Species in the Initiation of Plant Retrograde Signaling

    Eduardo-Antonio Trillo-Hernández1, Arturo Duarte Sierra2, Martín Ernesto Tiznado-Hernández1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 905-913, 2022, DOI:10.32604/phyton.2022.018118 - 24 January 2022

    Abstract

    The interaction between the nucleus and the different organelles is important in the physiology of the plant. Reactive oxygen species (ROS) are a by-product of the oxidation of organic molecules to obtain energy by the need to carry out the electron transfer between the different enzymatic complexes. However, they also have a role in the generation of what is known as retrograde signaling. This signal comes from the different organelles in which the oxidation of molecules or the electron transference is taking place such as mitochondria and chloroplasts. Furthermore, ROS can also induce the release

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  • Open Access

    ARTICLE

    Effects of High-Temperature Stress on Photosynthetic Characteristics and Antioxidant Enzyme System of Paeonia ostii

    Xiaoxiao Wang1, Ziwen Fang1, Daqiu Zhao1, Jun Tao1,2,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 599-615, 2022, DOI:10.32604/phyton.2022.017881 - 26 October 2021

    Abstract

    Paeonia ostii is an economically important oil crop, which has been widely cultivated in the middle and lower reaches of the Yangtze River in China in recent years. Although P. ostii is highly adaptable to the environment, the prolonged high summer temperature in this region severely inhibits its growth, which adversely affects seed yield and quality. In this study, P. ostii plants were subjected to 20°C/15°C (day/night) and 40°C/35°C (day/night) temperatures for 15 days. The changes in physiological and biochemical indicators of P. ostii under high-temperature stress were initially investigated. The results showed that with the deepening of leaf

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  • Open Access

    ARTICLE

    Oxidative stress indicators in human and bottlenose dolphin leukocytes in response to a pro-inflammatory challenge

    TARYN E. SYMON1, RAMÓN GAXIOLA-ROBLES1,2, CLAUDIA J. HERNÁNDEZ-CAMACHO3, TANIA ZENTENO-SAVÍN1,*

    BIOCELL, Vol.45, No.6, pp. 1621-1630, 2021, DOI:10.32604/biocell.2021.016302 - 01 September 2021

    Abstract Marine mammals undergo cycles of tissue ischemia and reperfusion during the dive response. Reperfusion injury can result in oxidative tissue damage and the activation of a pro-inflammatory immune response. The risk of oxidative damage is reduced by antioxidants. Our hypothesis is that the reported higher antioxidant defenses within marine mammal tissues provide additional protection in situations that produce oxidative stress, like inflammation, in comparison to terrestrial mammal tissues. Leukocytes were isolated from the whole blood of Pacific bottlenose dolphins (Tursiops truncatus gilli) and humans (Homo sapiens) and were exposed to lipopolysaccharides (LPS, 10 µg/mL) in vitro to simulate… More >

  • Open Access

    ARTICLE

    Phenotype, Physiology, and Gene Expression of Barley Seedlings in Response to Nano Zinc Oxide Stress

    Mengyuan Dong#, Rong Sun#, Qianhui Yang, Lantian Zhang, Yangying Yong, Yunxia Fang, Xian Zhang, Xiaoqin Zhang*, Dawei Xue*

    Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1589-1598, 2021, DOI:10.32604/phyton.2021.017465 - 28 June 2021

    Abstract In recent years, zinc oxide nanoparticles (ZnO NPs) have been widely used as zinc fertilizers and pesticides. The use of ZnO NPs in this way can provide benefits to humans, but also has potential risks. ZnO NPs inevitably enter the environment during their production and use, which affects the ecological environment and crop growth. In order to investigate the phenotype, physiology, and gene expression of barley (Hordeum vulgare L.) seedlings under ZnO NPs stress, the barely cultivars ZJU3 (P21), Golden Promise (GP) and L23 were chosen for study. Different ZnO NPs concentrations were applied to compare… More >

  • Open Access

    ARTICLE

    Hellebrigenin induces apoptosis in colorectal cancer Cells through induction of excessive reactive oxygen species

    CHUNJIAO LIU1,2, QINHONG KONG1,2, FENG PAN1,2, SHAN JIANG1,2, LINGJIE MENG1,2, GAI HUANG1,2, LIDAN LU1,2, SANHUA LI1,2,*, YUN LIU1,2,3,*

    BIOCELL, Vol.45, No.4, pp. 943-951, 2021, DOI:10.32604/biocell.2021.015836 - 22 April 2021

    Abstract Traditional Chinese medicine (TCM) has been increasingly applied in both preventing and treating a variety of cancers in the last decades, attributing to its fewer side effects as compared with chemotherapy drugs. Hellebrigenin, a component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported to have an obvious anti-cancer activity on various cancers. However, the effect and mechanism of hellebrigenin on colorectal cancers were still unknown. Herein, the present study demonstrated hellebrigenin significantly reduced viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in More >

  • Open Access

    ARTICLE

    Overexpression of rice F-box phloem protein gene OsPP12-A13 confers salinity tolerance in Arabidopsis

    CHUNKUN FAN, YONGPENG ZHANG, CHUNBAO YANG, YAWEI TANG, JI QU, BU JIE, DEJI QUZHEN, LIYUN GAO*

    BIOCELL, Vol.45, No.4, pp. 1121-1135, 2021, DOI:10.32604/biocell.2021.014336 - 22 April 2021

    Abstract Salinity is a serious challenge for agriculture production by limiting the arable land. Rice is a major staple food crop but very sensitive to salt stress. In this study, we used Arabidopsis for the functional characterization of a rice F-box gene LOC_Os04g48270 (OsPP12-A13) under salinity stress. OsPP12-A13 is a nuclear-localized protein that is strongly upregulated under salinity stress in rice and showed the highest expression in the stem, followed by roots and leaves. Two types of transgenic lines for OsPP12-A13 were generated, including constitutive tissue over-expression using the CaMV35S promoter and phloem specific over-expression using the pSUC2 promoter.… More >

  • Open Access

    REVIEW

    Application of photodynamic therapy in cancer: challenges and advancements

    ZIXUAN WANG1,#, HONGMEI PENG2,#, WEI SHI4,#, LU GAN1, LIPING ZHONG1, JIAN HE1, LINLIN XIE1, PAN WU1, YONGXIANG ZHAO1, ZHIMING DENG3,*, HONGLIANG TANG4, YONG HUANG1,3,*

    BIOCELL, Vol.45, No.3, pp. 489-500, 2021, DOI:10.32604/biocell.2021.014439 - 03 March 2021

    Abstract Although great achievements have been made in the past decades in medicine, cancer remains a worldwide public health issue. Surgery is usually accompanied by shortcomings such as residual lesions and poor treatment effects, and the successive appearance of other treatment methods, such as radiotherapy and chemotherapy, has not changed the postoperative recurrence rate, toxicity, and side effects. However, the advent of photodynamic therapy has greatly improved this situation. Photodynamic therapy is an emerging tumor diagnosis and treatment technology with good application prospects, photodynamic therapy uses a specific wavelength of light to excite a photosensitizer to More >

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