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  • Open Access

    ARTICLE

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

    JINGLONG CAO1,#, SHUMEI LI2,#, TONG ZHANG1,#, JIAN LIU1, WENSHUANG HOU1, ANQI WANG1, CHANG WANG3,4,*, CHENGHAO JIN1,3,5,*

    BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474

    Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated… More > Graphic Abstract

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    ARTICLE

    Application of Plant Growth-Promoting Bacteria as an Eco-Friendly Strategy for Mitigating the Harmful Effects of Abiotic Stress on Plants

    Ahmed Hassan Abdou1,*, Omar Abdullah Alkhateeb2, Hossam Eldin Hamed Mansour3, Hesham S. Ghazzawy4, Muayad Saud Albadrani5, Nadi Awad Al-harbi6, Wasimah B. Al-Shammari7, Khaled Abdelaal8,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.12, pp. 3305-3321, 2023, DOI:10.32604/phyton.2023.044780

    Abstract Plant growth-promoting bacteria (PGPB) play an important role in improving agricultural production under several abiotic stress factors. PGPB can be used to increase crop growth and development through hormonal balance and increase nutrient uptake. The positive effect of PGPB may be due to its pivotal role in morphophysiological and biochemical characteristics like leaf number, leaf area, and stem length. Furthermore, relative water content, chlorophyll content, carotenoids, antioxidant enzymes, and plant hormones were improved with PGPB treatment. Crop yield and yield components were also increased with PGPB treatment in numerous crops. The anatomical structure of plant… More >

  • Open Access

    ARTICLE

    Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

    ZIYU LIU1,2, AKIKO OKANO3,4, EMIKO SANADA1,3,4, YUSHI FUTAMURA3,4, TOSHIHIKO NOGAWA3,5, KOSUKE ISHIKAWA6, KENTARO SEMBA7,8, JIANG LI9, XIAOMENG LI10, HIROYUKI OSADA3,4,11,*, NOBUMOTO WATANABE1,2,4,*

    Oncology Research, Vol.31, No.5, pp. 655-666, 2023, DOI:10.32604/or.2023.030248

    Abstract

    Myc belongs to a family of proto-oncogenes that encode transcription factors. The overexpression of c-Myc causes many types of cancers. Recently, we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library. The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained. In this study, we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp. RK19-A0402 strongly inhibits c-Myc transcriptional activity. After purification of the hit broth, we identified compounds closely related to the aglycone

    More > Graphic Abstract

    Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

  • Open Access

    REVIEW

    A Review on Selenium Function under Oxidative Stress in Plants Focusing on ROS Production and Detoxification

    Armin Saed-Moucheshi1,*, Elham Rezaei Mirghaed2

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 1921-1941, 2023, DOI:10.32604/phyton.2023.027810

    Abstract

    One of the main reasons of the annual reduction in plant production all around the world is the occurrence of abiotic stresses as a result of an unpredicted changes in environmental conditions. Abiotic stresses basically trigger numerous pathways related to oxygen free radicals’ generation resulting in a higher rate of reactive oxygen species (ROS) production. Accordingly, higher rate of oxygen free radicals than its steady state causes to oxidize various types of molecules and compartments within the plants’ cells and tissues. Oxidative stress is the result of high amount free radicals of oxygen interfering with different

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  • Open Access

    ARTICLE

    Calcitriol induces post-thawed bovine sperm capacitation

    ANA CECILIA LIAUDAT, FRANCISCA EBEL, BIANCA ANA OPIZZO, MARINA AURORA GONZALEZ, DAMIÁN BLOIS, PABLO BOSCH#, NANCY RODRIGUEZ#,*

    BIOCELL, Vol.47, No.5, pp. 1135-1143, 2023, DOI:10.32604/biocell.2023.027628

    Abstract Background: Capacitation is a set of physiological changes sperms undergo to acquire fertilizing capacity. In vivo, this process is directly associated with high calcium levels in sperm cytoplasm. Calcitriol, the vitamin D hypercalcemic metabolite, is related to human sperm motility, capacitation, and acrosome reaction. This work aimed to study the effect of calcitriol on bull sperm quality parameters and capacitation. Methods: One million freeze-thawed spermatozoa were obtained from different bulls and treated with 20 nM of calcitriol for 30 min. Untreated cells (negative control) and treated ones with calcitriol or heparin (100 µg/mL, positive capacitation control) were… More >

  • Open Access

    ARTICLE

    Salicylic Acid Application Mitigates Oxidative Damage and Improves the Growth Performance of Barley under Drought Stress

    Shah Mohammad Naimul Islam1, Niloy Paul1, Md. Mezanur Rahman2, Md. Ashraful Haque1, Md. Motiar Rohman3, Mohammad Golam Mostofa4,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1513-1537, 2023, DOI:10.32604/phyton.2023.025175

    Abstract Drought is a severe environmental constraint, causing a significant reduction in crop productivity across the world. Salicylic acid (SA) is an important plant growth regulator that helps plants cope with the adverse effects induced by various abiotic stresses. The current study investigated the potential effects of SA on drought tolerance efficacy in two barley (Hordeum vulgare) genotypes, namely BARI barley 5 and BARI barley 7. Ten-day-old barley seedlings were exposed to drought stress by maintaining 7.5% soil moisture content in the absence or presence of 0.5, 1.0 and 1.5 mM SA. Drought exposure led to severe… More >

  • Open Access

    ARTICLE

    Silicon and Nitric Oxide-Mediated Regulation of Growth Attributes, Metabolites and Antioxidant Defense System of Radish (Raphanus sativus L.) under Arsenic Stress

    Savita Bhardwaj1, Tunisha Verma1, Ali Raza2,*, Dhriti Kapoor1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 763-782, 2023, DOI:10.32604/phyton.2023.025672

    Abstract

    Arsenic (As) contaminated food chains have emerged as a serious public concern for humans and animals and are known to affect the cultivation of edible crops throughout the world. Therefore, the present study was designed to investigate the individual as well as the combined effects of exogenous silicon (Si) and sodium nitroprusside (SNP), a nitric oxide (NO) donor, on plant growth, metabolites, and antioxidant defense systems of radish (Raphanus sativus L.) plants under three different concentrations of As stress, i.e., 0.3, 0.5, and 0.7 mM in a pot experiment. The results showed that As stress reduced the

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  • Open Access

    ARTICLE

    A Novel Dominant Allele from 93-11, ES(4), Represses Reactive Oxygen Species Scavenging and Leads to Early-Senescence in Rice

    Zhishu Jiang#, Cong Gan#, Yulian Liu, Xiaoli Lin, Limei Peng, Yongping Song, Xiaowei Luo, Jie Xu*

    Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 665-677, 2023, DOI:10.32604/phyton.2023.025266

    Abstract Senescence is the last developmental process in plant, which has an important impact on crop yield and quality. In this study, a stable hereditary early-senescence line BC64 was isolated from the high-generation recombinant inbred lines of 93-11 and Wuyunjing7 (W7). Genetic analysis showed that the premature aging phenotype was controlled by a dominant gene derived from 93-11. By linkage analysis, the gene was primarily mapped in the region between marker B4 and B5 near the centromere of chromosome 4, described as ES(4). Through multiple backcrossing with W7, the near-isogenic line of ES(4) (NIL-ES(4)) was obtained. Compared More >

  • Open Access

    REVIEW

    Hypoxia-induced reactive oxygen species in organ and tissue fibrosis

    LINSHEN XIE1, QIAOLAN WANG1, JINGXUAN MA1, YE ZENG2,*

    BIOCELL, Vol.47, No.2, pp. 261-267, 2023, DOI:10.32604/biocell.2023.024738

    Abstract Fibrosis is the end-stage change of damaged tissues in various human diseases, which can lead to permanent scarring or organ malfunction. Hypoxia leads to oxidative stress, mitochondrial dysfunction, and inflammation in dysfunctional organs and tissues. Oxidative stress resulting from the overproduction of reactive oxygen species plays a central role in the fibrosis of injured organs. This review addresses the updated knowledge of the relationship between hypoxia and tissue fibrosis mediated by the reactive oxygen species pathway. Moreover, novel anti-fibrotic strategies are discussed, which may suppress reactive oxygen species and organ fibrosis. More >

  • Open Access

    ARTICLE

    Schisandrin B exerts anticancer effects on human gastric cancer cells through ROS-mediated MAPK, STAT3, and NF-κB pathways

    TIANZHU LI1,#, YU ZHANG2,#, TONG ZHANG2,#, YANNAN LI2, HUI XUE2, JINGLONG CAO2, WENSHUANG HOU2, YINGHUA LUO3,*, CHENGHAO JIN2,4,*,

    BIOCELL, Vol.47, No.1, pp. 195-204, 2023, DOI:10.32604/biocell.2023.025593

    Abstract Schisandrin B (Sch B) is a monomer with anti-cancer and anti-inflammatory effects, which are isolated from the plant Schisandra chinensis (Turcz) Baillon. We investigated the anti-gastric cancer (GC) effects of Sch B and its underlying molecular mechanisms. The Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell lines. Hoechst/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch B. Western blotting was used to evaluate the effects of Sch B on downstream apoptotic proteins. The DCFH-DA fluorescent probe was… More >

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