Huilong Ren¹, Xiaoying Zhuang^2,3,*, Timon Rabczuk¹

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 353-383, 2019, DOI:10.32604/cmes.2019.05146

Abstract A dual-support smoothed particle hydrodynamics (DS-SPH) that allows variable smoothing lengths while satisfying the conservations of linear momentum, angular momentum and energy is developed. The present DS-SPH is inspired by the dual-support, a concept introduced from dual-horizon peridynamics from the authors and applied here to SPH so that the unbalanced interactions between the particles with different smoothing lengths can be correctly considered and computed. Conventionally, the SPH formulation employs either the influence domain or the support domain. The concept of dual-support identifies that the influence domain and the support domain involves the duality and should More >

Takeo Matsumoto^1,*, Chizuru Hirooka¹, Yong Fan¹, Junfeng Wang¹, Naoki Mori¹, Eijiro Maeda¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 81-81, 2019, DOI:10.32604/mcb.2019.07102

Abstract Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, however, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]. However, to the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response. It has been reported that mechanical deformation of the nuclei causes transcription upregulation… More >

Linhong Deng^1,*, Yang Jin², Mingzhi Luo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 80-80, 2019, DOI:10.32604/mcb.2019.07370

Abstract Airway smooth muscle cells (ASMCs) exists within the bronchial airway wall in a form of spirally winding bundles [1]. This pattern emerges early during embryonic development and is involved in airway branching [2], providing the airway appropriate contractile capacity and resistance to circumferential tension in health or causing excessive airway narrowing in disease such as asthma. Despite its importance, the cause of ASMCs self-organization remains largely a mystery. Previously, we have demonstrated in 2D that ASMCs can sense the curvature in their microenvironment and change behaviors in differentiation, orientation and migration accordingly [3]. Here we… More >

Mingxing Ouyang^1,*, Zhili Qian¹, Yang Jin¹, Linhong Deng¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 65-65, 2019, DOI:10.32604/mcb.2019.06642

Abstract The collective functions at cell population level rely on cell-cell communications with or without direct contacts [1-3]. The long-range biomechanical force propagating across certain scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population [3-5]. Whether and how cells communicate with each other mechanically in a distant manner remains largely to be explored. Airway smooth muscle (ASM) cells are one crucial component in providing mechanical support and contraction force for the bronchial tubes in respiratory system, whereas the mechanical property of ASM is also associated with asthma… More >

Yu Gao¹, Meiyue Wang¹, Yanting He¹, Lanlan Li¹, Xiaodong Cui¹, Min Cheng^1,*, Xiaoyun Zhang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 93-93, 2019, DOI:10.32604/mcb.2019.05758

Abstract This study examines the effects of P53 in transdifferentiation of endothelial progenitor cells (EPCs) into smooth muscle cells induced by oscillatory shear stress. Endothelial progenitor cells (EPCs) were planted on slide and treated with 4 dyne/cm2 oscillatory shear stress (OSS). Results showed that the expression P53 was decreased time dependent after OSS. The OSS also attenuated the endothelial cells marker vWF and CD31 expression but enhanced the marker of smooth muscle cell α-SMA and SM22 expression in EPCs. After EPCs were pretreated with P53 agonist, the changes of angiogenesis in vitro were detected by matrix More >

Jifeng Li^1,#, Yanting He^1,#, Xiaoyun Zhang¹, Hong Li¹, Xiumei Guan¹, Min Cheng^1,*, Xiaodong Cui^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 89-89, 2019, DOI:10.32604/mcb.2019.05753

Abstract Objective: The propose of the study is to investigate the specific effects of the mechanically sensitive channel Kir2.1 on the transdifferentiation of EPCs so as to understand the molecular mechanism of pathological vascular remodeling. Methods: Endothelial progenitor cells (EPCs) were isolated from rat bone marrow and cultured in EGM2 medium in vitro. The recombinant lentiviral vectors carrying Kir2.1 (NM_017296.1) gene was designed and constructed in order to overexpress the gene. The smooth muscle cells (SMCs) molecules marker on EPCs, such as α-SMA, FSP1 and α-SM22, were detected by RT-PCR and cellular immunofluorescence. In addition, cell angiogenic capacity… More >

N. Kins Burk Sunil^{1, *}, R. Ganesan², B. Sankaragomathi³

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 351-375, 2019, DOI:10.31614/cmes.2018.04484

Abstract Obstructive Sleep Apnea (OSA) is a respiratory syndrome that occurs due to insufficient airflow through the respiratory or respiratory arrest while sleeping and sometimes due to the reduced oxygen saturation. The aim of this paper is to analyze the respiratory signal of a person to detect the Normal Breathing Activity and the Sleep Apnea (SA) activity. In the proposed method, the time domain and frequency domain features of respiration signal obtained from the PPG device are extracted. These features are applied to the Classification and Regression Tree (CART)-Particle Swarm Optimization (PSO) classifier which classifies the More >

S. Kshrisagar¹, A. Francis¹, J. J. Yee², S. Natarajan¹, C. K. Lee^3,*

CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 481-502, 2019, DOI:10.32604/cmc.2019.07967

Abstract In this paper, the node based smoothed-strain Abaqus user element (UEL) in the framework of finite element method is introduced. The basic idea behind of the node based smoothed finite element (NSFEM) is that finite element cells are divided into subcells and subcells construct the smoothing domain associated with each node of a finite element cell [Liu, Dai and Nguyen-Thoi (2007)]. Therefore, the numerical integration is globally performed over smoothing domains. It is demonstrated that the proposed UEL retains all the advantages of the NSFEM, i.e., upper bound solution, overly soft stiffness and free from More >

Mirza Hasanuzzaman^1,*, Aditya Banerjee², M. H. M. Borhannuddin Bhuyan^3,4, Aryadeep Roychoudhury^2,*, Jubayer Al Mahmud⁵ and Masayuki Fujita³

Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 185-221, 2019, DOI:10.32604/phyton.2019.07559

Abstract In the era of climate change, abiotic stresses (e.g., salinity, drought, extreme temperature, flooding, metal/metalloid(s), UV radiation, ozone, etc.) are considered as one of the most complex environmental constraints that restricts crop production worldwide. Introduction of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint, and to produce these types of tolerant crops. Several bioengineering mechanisms involved in stress signaling are being adopted in this regard. One example of this kind of manipulation is the osmotic adjustment. The quarternary ammonium compound glycinebetaine (GB), also originally referred to as betaine is a methylated… More >

Ozturk M¹, S Gucel², V Altay³, MSA Ahmad⁴, MY Ashraf⁵, M Ashraf⁶

Phyton-International Journal of Experimental Botany, Vol.88, No.1, pp. 63-68, 2019, DOI:10.32604/phyton.2019.04574

Abstract This paper presents the work conducted on the chemical constituents of some common and widely distributed halophyte taxa from Cyprus with the aim that these studies will help in the evaluation of halophytes for different economical purposes. The plant species of Crithmum maritimum L., Limbarda crithmoides (L.) Dumort, Atriplex portulacoides L., Salsola kali L., Atriplex halimus L., Limonium oleifolium Mill., L. meyeri (Boiss.) Kuntze; and Tetraena alba (L.f.) Beier & Thulin were collected in the middle of July. The shoot tissue and leaf samples were collected from the natural habitats and left for drying under… More >