M. Al-Saad¹, C. A. Suarez^{2, 4}, A. Obeidat², S. P. A. Bordas^{1, 2, 3, *}, S. Kulasegaram¹

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.3, pp. 831-862, 2020, DOI:10.32604/cmes.2020.08527 - 01 March 2020

Abstract Thrombosis plays a crucial role in atherosclerosis or in haemostasis when a blood vessel is injured. This article focuses on using a meshless particle-based Lagrangian numerical technique, the smoothed particles hydrodynamic (SPH) method, to study the flow behaviour of blood and to explore the flow parameters that induce formation of a thrombus in a blood vessel. Due to its simplicity and effectiveness, the SPH method is employed here to simulate the process of thrombogenesis and to study the effect of various blood flow parameters. In the present SPH simulation, blood is modelled by two sets More >

Wujie Hu¹, Gonglin Yuan^{1, *}, Hongtruong Pham²

CMC-Computers, Materials & Continua, Vol.62, No.2, pp. 787-800, 2020, DOI:10.32604/cmc.2020.02993

Abstract It is well known that Newton and quasi-Newton algorithms are effective to small and medium scale smooth problems because they take full use of corresponding gradient function’s information but fail to solve nonsmooth problems. The perfect algorithm stems from concept of ‘bundle’ successfully addresses both smooth and nonsmooth complex problems, but it is regrettable that it is merely effective to small and medium optimization models since it needs to store and update relevant information of parameter’s bundle. The conjugate gradient algorithm is effective both large-scale smooth and nonsmooth optimization model since its simplicity that utilizes More >

Shichao Ma^{1, 2, *}, Xin Ning^{1, 2, *}, Liang Wang³

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.1, pp. 49-59, 2020, DOI:10.32604/cmes.2020.06911 - 01 January 2020

Abstract Friction systems are a kind of typical non-linear dynamical systems in the actual engineering and often generate abundant dynamics phenomena. Because of non-smooth characteristics, it is difficult to handle these systems by conventional analysis methods directly. At the same time, random perturbation often affects friction systems and makes these systems more complicated. In this context, we investigate the steady-state stochastic responses and stochastic P-bifurcation of friction systems under random excitations in this paper. And in order to retain the non-smooth of friction system, the generalized cell mapping (GCM) method is first used to the original… More >

Haresh Kumar Sharma, Kriti Kumari, Samarjit Kar

Intelligent Automation & Soft Computing, Vol.25, No.1, pp. 1-14, 2019, DOI:10.31209/2018.100000036

Abstract This article focuses on the use of the rough set theory in modeling of time series forecasting. In this paper, we have used the double exponential smoothing (DES) model for forecasting. The classical DES model has been improved by using the rough set technique. The improved double exponential smoothing (IDES) method can be used for the time series data without any statistical assumptions. The proposed method is applied on tourism demand of the air transportation passenger data set in Australia and the results are compared with the classical DES model. It has been observed that More >

Huilong Ren¹, Xiaoying Zhuang^2,3,*, Timon Rabczuk¹

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 353-383, 2019, DOI:10.32604/cmes.2019.05146

Abstract A dual-support smoothed particle hydrodynamics (DS-SPH) that allows variable smoothing lengths while satisfying the conservations of linear momentum, angular momentum and energy is developed. The present DS-SPH is inspired by the dual-support, a concept introduced from dual-horizon peridynamics from the authors and applied here to SPH so that the unbalanced interactions between the particles with different smoothing lengths can be correctly considered and computed. Conventionally, the SPH formulation employs either the influence domain or the support domain. The concept of dual-support identifies that the influence domain and the support domain involves the duality and should More >

Takeo Matsumoto^1,*, Chizuru Hirooka¹, Yong Fan¹, Junfeng Wang¹, Naoki Mori¹, Eijiro Maeda¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 81-81, 2019, DOI:10.32604/mcb.2019.07102

Abstract Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, however, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]. However, to the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response. It has been reported that mechanical deformation of the nuclei causes transcription upregulation… More >

Linhong Deng^1,*, Yang Jin², Mingzhi Luo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 80-80, 2019, DOI:10.32604/mcb.2019.07370

Abstract Airway smooth muscle cells (ASMCs) exists within the bronchial airway wall in a form of spirally winding bundles [1]. This pattern emerges early during embryonic development and is involved in airway branching [2], providing the airway appropriate contractile capacity and resistance to circumferential tension in health or causing excessive airway narrowing in disease such as asthma. Despite its importance, the cause of ASMCs self-organization remains largely a mystery. Previously, we have demonstrated in 2D that ASMCs can sense the curvature in their microenvironment and change behaviors in differentiation, orientation and migration accordingly [3]. Here we… More >

Mingxing Ouyang^1,*, Zhili Qian¹, Yang Jin¹, Linhong Deng¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 65-65, 2019, DOI:10.32604/mcb.2019.06642

Abstract The collective functions at cell population level rely on cell-cell communications with or without direct contacts [1-3]. The long-range biomechanical force propagating across certain scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population [3-5]. Whether and how cells communicate with each other mechanically in a distant manner remains largely to be explored. Airway smooth muscle (ASM) cells are one crucial component in providing mechanical support and contraction force for the bronchial tubes in respiratory system, whereas the mechanical property of ASM is also associated with asthma… More >

Yu Gao¹, Meiyue Wang¹, Yanting He¹, Lanlan Li¹, Xiaodong Cui¹, Min Cheng^1,*, Xiaoyun Zhang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 93-93, 2019, DOI:10.32604/mcb.2019.05758

Abstract This study examines the effects of P53 in transdifferentiation of endothelial progenitor cells (EPCs) into smooth muscle cells induced by oscillatory shear stress. Endothelial progenitor cells (EPCs) were planted on slide and treated with 4 dyne/cm2 oscillatory shear stress (OSS). Results showed that the expression P53 was decreased time dependent after OSS. The OSS also attenuated the endothelial cells marker vWF and CD31 expression but enhanced the marker of smooth muscle cell α-SMA and SM22 expression in EPCs. After EPCs were pretreated with P53 agonist, the changes of angiogenesis in vitro were detected by matrix More >

Jifeng Li^1,#, Yanting He^1,#, Xiaoyun Zhang¹, Hong Li¹, Xiumei Guan¹, Min Cheng^1,*, Xiaodong Cui^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 89-89, 2019, DOI:10.32604/mcb.2019.05753

Abstract Objective: The propose of the study is to investigate the specific effects of the mechanically sensitive channel Kir2.1 on the transdifferentiation of EPCs so as to understand the molecular mechanism of pathological vascular remodeling. Methods: Endothelial progenitor cells (EPCs) were isolated from rat bone marrow and cultured in EGM2 medium in vitro. The recombinant lentiviral vectors carrying Kir2.1 (NM_017296.1) gene was designed and constructed in order to overexpress the gene. The smooth muscle cells (SMCs) molecules marker on EPCs, such as α-SMA, FSP1 and α-SM22, were detected by RT-PCR and cellular immunofluorescence. In addition, cell angiogenic capacity… More >