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  • Open Access

    REVIEW

    Cancer Drug Development in Never-Smoker Lung Cancer: Targeted and Immune-Based Therapeutic Strategies

    Cristian Cojocaru, Marcel Costuleanu*, Ovidiu Rusalim Petriș, Ruxandra Cojocaru, Decebal Vasîncu, Elena Cojocaru

    Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.080024 - 16 July 2026

    Abstract Lung cancer in individuals who have never smoked (LCINS) represents a clinically and biologically distinct subset of non–small cell lung cancer, driven predominantly by oncogenic alterations rather than tobacco-related mutagenesis. This review aims to summarize current and emerging targeted and immune-based therapeutic strategies in LCINS individuals. These patients present a molecular profile that differs substantially from tobacco-associated disease and has direct consequences for treatment selection. Evidence published over the past five years has clarified how these molecular features shape treatment response and resistance in this setting. Particular attention is given to tumors with alterations in… More >

  • Open Access

    ARTICLE

    Multi-Class Severity-Aware Fire and Smoke Detection Using YOLOv12 for Sustainable Intelligent Real-Time Monitoring

    Aminah Almehmadi1, Ayman Noor1, Aziza I. Noor2, Hanan Almukhalfi1, Talal H. Noor1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.083503 - 30 June 2026

    Abstract Fire emergencies have long posed a serious threat to people’s lives, real estate assets, and environmental sustainability in civilized societies, especially when combustible events are detected at late stages of development. Recent advancements in computer vision–based fire detection have enabled automated real-time monitoring; however, most solutions either detect the existence of fire/smoke or employ binary decision-making, which limits visual monitoring systems from being risk-aware. This work introduces a severity-aware fire/smoke detection model that supports intelligent monitoring systems in detecting visual hazards. The goal is to identify varying levels of fire intensity and smoke density and… More >

  • Open Access

    ARTICLE

    Enhancing IoMT Network Threat Detection with Data Balancing for Multi-Class Attack Classification on CICIoMT2024 Dataset

    Taghreed Alkhodaidi1,*, Wadee Alhalabi1, Miada Almasre2

    CMC-Computers, Materials & Continua, Vol.88, No.2, 2026, DOI:10.32604/cmc.2026.081665 - 15 June 2026

    Abstract The rapid growth of the IoMT has resulted in critical security threats to healthcare infrastructure, which require highly sophisticated IDSs that can detect a wide range of and unbalanced attack patterns. This study has addressed a critical challenge faced by network security data, which is class imbalance, by presenting a comprehensive evaluation of data balancing techniques on both a real-world standard data set, CICIoMT2024, and a synthetic data set, SynIoMT2026, which we generated to mimic the characteristics of the standard data set for developing a highly controlled data set. Three data balancing techniques, ADASYN, Sample… More >

  • Open Access

    ARTICLE

    Deep Learning-Assisted Modelling of Electro-Osmotic Flow in Thin Film Sutterby Hybrid Nanofluid over a Porous Inclined Sheet

    Irfan Saif Ud Din1, Imran Siddique2,3,4,5, Zohaib Zahid1, Muhammad Nadeem6, Ibrahim Alraddadi2,*, Taha Radwan7,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.081726 - 27 May 2026

    Abstract This study examines the variable thermal conductivity and electroosmotic performance of Sutterby hybrid nanofluid (SBHNF) thin film flow over a stretched inclined sheet using an artificial neural network (ANN)-based on NARX (Multilayer Nonlinear Autoregressive Networks with Exogenous Inputs) multiple-layer backpropagation simulation with the Levenberg-Marquardt algorithm (LMA). AA7075 and AA7072 nanoparticles suspended in sodium alginate (SA) base fluid make up the hybrid nanofluid (HNF), which was selected due to its improved heat transfer properties and superior thermal conductivity. The model’s practical applicability is enhanced by melting heat, nonlinear thermal radiation, boundary slip, and Newtonian heating effects,… More >

  • Open Access

    ARTICLE

    Alleviation of Salt Stress on the Growth and Active Constituents of Chamomile (Matricaria chamomilla L.) Using Glutathione and Hydrogen Peroxide

    Wessam M. Serag El-Din1,*, Kamal E. Attia1, Taghreed E. Eissa2,*, Tarek M. Noor El-Deen2, Hadeer Darwish1,3, Ghadah H. Al Hawas4,5, Modhi O. Alotaibi6,7

    Phyton-International Journal of Experimental Botany, Vol.95, No.5, 2026, DOI:10.32604/phyton.2026.078357 - 27 May 2026

    Abstract Water salinity is a growing environmental concern that significantly impacts soil health, agricultural productivity, and freshwater sustainability, especially in arid regions. This study evaluated the comparative effects of foliar-applied glutathione (GSH) and hydrogen peroxide (H2O2) on growth, flower yield, essential oil composition, and physiological responses of Matricaria chamomilla L. under water salinity levels. The experiment was conducted during the 2022/2023 and 2023/2024 seasons at the Experimental Farm of El-Quassassin, Ismailia, Egypt, using a factorial randomized complete block design with three replicates. Foliar applications of GSH (1, 2, and 3 mM) and H2O2 (5, 10, and 20 mM)… More >

  • Open Access

    REVIEW

    Cross-Tolerance in a Changing Climate: Physiological Responses to Combined Abiotic Stress

    Damilola Olofintuyi, Ayesha Siddika, Abdollah Monfared, Hong Zhang, Jennifer Smith*

    Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.079971 - 28 April 2026

    Abstract Climate change is increasing the frequency and intensity of overlapping abiotic stresses, making cross-tolerance a critical component of plant resilience. While single stress responses have been extensively characterized, plants in natural and agricultural environments frequently encounter simultaneous or sequential stresses such as drought–heat, light–drought, and drought–salinity, which trigger nonadditive and often unpredictable physiological outcomes that vary with stress intensity, timing, and species. This review synthesizes current understanding of the mechanisms underlying cross-tolerance, emphasizing how contradictory signals, stress timing, and physiological integration shape plant responses under combined stress. We highlight how stomatal regulation, leaf energy balance,… More >

  • Open Access

    ARTICLE

    Elicitors of Salt Stress Tolerance during Germination and Early Growth of Basil (Ocimum basilicum L.)

    Edilma Alves da Silva1, João Batista Costa Neto1, Silvana Nunes Barreto1, Matheus Henrique de Souza Alencar1, Maria Valdiglezia de Mesquita Arruda2, Daise Feitoza da Rocha2, Salvador Barros Torres2, Francisco Vanies da Silva Sá3,*, Kleane Targino Oliveira Pereira2, Cynthia Cavalcanti de Albuquerque1

    Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.077713 - 28 April 2026

    Abstract Salt stress attenuators assist seed germination by reducing the effects of osmotic and ionic stress, y promoting water uptake, they stabilize enzymes and enhance metabolic tolerance, resulting in higher germination rates and more uniform early development. This study evaluates the effects of applying salt stress attenuators on the germination and seedling formation of O. basilicum as a pre-germination treatment. Two cultivars, Limoncino (tolerant) and Genaro de Menta (sensitive), were subjected to pre-germination treatments combining salt stress with a stress-attenuating agent: no pre-germination treatment and no salt stress; salt stress (6.98 dS m1 NaCl); hydropriming + salt stress;… More >

  • Open Access

    ARTICLE

    Numerical Simulations of Extreme Deformation Problems in Granular-Dominated Hazard from Indoor to Engineering Geological Scale: A Comparative Study

    Yuxin Tian1, Wangxin Yu1, Wanqing Yuan1, Qingquan Liu1,*, Xiaoliang Wang1,2,3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.078776 - 30 March 2026

    Abstract Granular flow, such as hopper discharge and debris flows, involves complex multi-scale, multi-phase, and multi-physics coupling, posing significant challenges for numerical simulation. Over the past two decades, methods like the Discrete Element Method (DEM), Smoothed Particle Hydrodynamics (SPH), and Depth-Averaging Method (DAM), have been developed to address these problems. However, their applicability across different scales remains unclear due to differences in physical assumptions and numerical algorithms. Therefore, a comprehensive evaluation is critically needed. This study selects three typical methods (DEM, SPH, and DAM) to examine their convergence behavior, boundary condition implementation, and limitations in physical More >

  • Open Access

    ARTICLE

    Mathematical and Computer Modeling of Electroosmotic Peristaltic Transport of a Biofluid with Double-Diffusive Convection and Thermal Radiation

    Yasir Khan1, Arshad Riaz2,*, Iqra Batool2, Safia Akram3, A. Alameer1, Ghaliah Alhamzi4

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.078060 - 30 March 2026

    Abstract Tangent hyperbolic fluids characterized by shear-thinning behavior, are widely utilized in diverse industrial and scientific fields such as polymer engineering, inkjet printing, biofluids modeling, thermal insulation materials, and chemical manufacturing. Additionally, double-diffusive convection involving simultaneous heat and mass transfer driven by temperature and concentration gradients plays a critical role in many natural and industrial systems, including oceanic circulation, geothermal energy extraction, crystal solidification, alloy formation, and enhanced oil recovery. The current work examines the peristaltic transport of a tangent hyperbolic nanofluid under the concurrent effects of thermal radiation, electroosmotic forces, slip boundary conditions, and double… More >

  • Open Access

    ARTICLE

    Electroosmotic Transport and Entropy Generation in ZnO-Williamson Nanoblood Flow through a Converging/Diverging Tapered Stenosed Artery

    Noor Fadiya Mohd Noor1,2,*, Noreen Sher Akbar3, Rashid Mehmood4, Muhammad Bilal Habib5

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.075694 - 30 March 2026

    Abstract Electroosmotic transport and entropy generation play a decisive role in regulating efficiency, stability, and energy cost of non-Newtonian nanoblood flows in stenosed arteries, particularly with tapered geometries. This study develops a unified model to analyze ZnO–Williamson nanoblood flow through a stenosed artery with converging, diverging, and non-tapered configurations, incorporating electroosmosis, viscous dissipation, and entropy production. The arterial walls are assumed to be electrically charged with a no-slip condition to induce electroosmotic propulsion along the endothelial surface. The partial differential equations are nondimensionalized to a coupled system of nonlinear ordinary differential equations, which are solved numerically… More >

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