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  • Open Access

    REVIEW

    How aging affects bone health via the intestinal micro-environment

    HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

  • Open Access

    REVIEW

    Reconstruction of the Hindlimb Locomotion of Confuciusornis (Aves) and Its Implication for the Origin of Avian Flight

    Xinsen Wei1, Ying Guo1,2,*, Yan Zhao1

    Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 49-61, 2023, DOI:10.32604/mcb.2023.041173

    Abstract As one of the most basal avian clades, the Confuciusornithids are ideal in revealing the early evolution of avian flight. Birds’ hindlimbs are functionally diverse and contain a wealth of information about their behavior. The hindlimb of Confuciusornis, however, has only been studied in detail in terms of functional morphology, and quantitative studies that directly assess locomotor ability are relatively lacking. This has led to certain controversies on the behavior of Confuciusornis. This paper reviews the debates over the life habits and take-off ability of Confuciusornis, which are closely related to their hindlimb function. Several methodologies adopted engineering techniques, including… More >

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