Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Mengjie Wang¹, Jingfa Li^2,*, Bo Yu², Nianrong Wang³, Xiaofeng Wang³, Tao Hu⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3055-3072, 2025, DOI:10.32604/fdmp.2025.071675 - 31 December 2025

Abstract The adaptation of existing natural gas pipelines for hydrogen transportation has attracted increasing attention in recent years. Yet, whether hydrogen and natural gas stratify under static conditions remains a subject of debate, and experimental evidence is still limited. This study presents an experimental investigation of the concentration distribution of hydrogen–natural gas mixtures under static conditions. Hydrogen concentration was measured using a KTL-2000M-H hydrogen analyzer, with a measurement range of 0–30% (by volume), an accuracy of 1% full scale (FS), and a resolution of 0.01%. Experiments were conducted in a 300 cm riser, filled with uniformly… More >

Xingkang Jiang^*, Jing Tian, Yong Xu

Canadian Journal of Urology, Vol.32, No.6, pp. 539-540, 2025, DOI:10.32604/cju.2025.073363 - 30 December 2025

Abstract This article has no abstract. More >

Chuang Meng^1,*, Yutong Bi¹, Bingji Zhang¹, Wentao Fu², Guang Chen³

Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1681-1694, 2025, DOI:10.32604/sdhm.2025.068732 - 17 November 2025

Abstract The lift-and-transverse type parking equipment, with its core advantages such as high space utilization, modular and flexible layout, and intelligent operation, has become an efficient solution to alleviate the urban parking problem. However, existing research still lacks a systematic evaluation of its structural performance, particularly in areas such as the fatigue characteristics of steel frame materials, stress distribution under dynamic loads, and resonance risk analysis. The stress amplitude (S) and fatigue life (N) relationship curve of Q235 steel, the material used in the steel frame of the lift-and-transverse type parking equipment, was obtained through fatigue… More >

Phillip Taboada¹, Rohit R. Badia¹, Dhillon Advano¹, Andrew Murphy¹, Christina Sze¹, Ryan J. Mauck¹, Jennifer Tse¹, Jeffrey Gahan², Claus G. Roehrborn¹, Ramy Goueli^1,*

Canadian Journal of Urology, Vol.32, No.5, pp. 491-499, 2025, DOI:10.32604/cju.2025.068150 - 30 October 2025

Abstract Background: Aquablation is a robotic-assisted, water jet-based transurethral therapy for benign prostatic hyperplasia (BPH). Concerns about postoperative hematuria led to the practice of limited transurethral resection (TUR) with cauterization. This study aimed to assess the impact of tranexamic acid (TXA) on hematuria outcomes when combined with limited TUR after Aquablation. Methods: We retrospectively analyzed men undergoing Aquablation at our institution (October 2020–July 2024). Demographic, prostate, surgical, and hematuria outcomes were extracted from electronic medical records. Kruskal-Wallis test compared medians. Results: Of 131 patients, 113 (86%) had limited TUR; 31 (27%) received 1 g TXA perioperatively. TXA… More >

ZiQi Zhao, MingYang Xu, ChaoYang Sun, PeiPei Li^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.012382

Abstract Hot isostatic pressing (HIP) is often utilized to obtain laser powder bed fused (LPBF) Ti-6Al-4V with good mechanical properties. To uncover the underlying mechanisms by which HIP improves the mechanical properties, several mechanisms are considered and examined against experimental data sets available in the literature. The results suggest that HIP improves mechanical properties by both reducing defect sizes below a critical threshold and altering the microstructure surrounding defects. Based on these findings, a pore healing model was developed, and optimized HIP processing parameter range (temperature, pressure, and soaking time) were proposed. Severe plastic deformation driven… More >

Ana Clara Ciglioni Salustiano^1,2, Gabriela Barbosa^1,3,4, Rodolfo Borges dos Reis^2,4, Amílcar Castro de Mattos^5,6, Athanase Billis⁶, Leonardo O. Reis^1,3,4,*

Oncology Research, Vol.33, No.11, pp. 3417-3428, 2025, DOI:10.32604/or.2025.068023 - 22 October 2025

Abstract Objective: The tumor microenvironment plays a pivotal role in prostate cancer progression and may differ across metastatic sites. This study aimed to evaluate and compare the primary and metastatic prostate adenocarcinoma tumor microenvironment. Methods: A total of 27 formalin-fixed paraffin-embedded tissue samples derived from 17 patients diagnosed with prostate adenocarcinoma, including the primary tumors, and the corresponding metastatic lymphatic and hematogenous lesions from various anatomical sites. Immunohistochemical labeling was performed using antibodies against Cluster of Differentiation 3 epsilon chain (CD3e), CD8 alpha chain (CD8a), Cluster of Differentiation 68 (CD68), Cluster of Differentiation 163 (CD163), Forkhead… More > Graphic Abstract

Brian Mweu^1,*, John Ndia²

Journal of Cyber Security, Vol.7, pp. 417-437, 2025, DOI:10.32604/jcs.2025.071765 - 10 October 2025

Abstract Static analysis methods are crucial in developing secure software, as they allow for the early identification of vulnerabilities before the software is executed. This systematic review follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines to assess static analysis techniques for software security enhancement. We systematically searched IEEE Xplore, Association for Computing Machinery (ACM) Digital Library, SpringerLink, and ScienceDirect for journal articles published between 2017 and 2025. The review examines hybrid analyses and machine learning integration to enhance vulnerability detection accuracy. Static analysis tools enable early fault detection but face persistent challenges. More >