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  • Open Access

    ARTICLE

    Cushioning Performance of Hilbert Fractal Sandwich Packaging Structures under Quasi-Static Compressions

    Xingye Xu1, Haiyan Song1,2,*, Lijun Wang1,2

    CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.1, pp. 275-292, 2023, DOI:10.32604/cmes.2022.022637

    Abstract The sandwich structure of cushioning packaging has an important influence on the cushioning performance. Mathematical fractal theory is an important graphic expression. Based on Hilbert fractal theory, a new sandwich structure was designed. The generation mechanism and recurrence formula of the Hilbert fractal were expressed by Lin’s language, and the second-order Hilbert sandwich structure was constructed from thermoplastic polyurethane. The constitutive model of the hyperelastic body was established by using the finite element method. With the unit mass energy absorption as the optimization goal, the fractal sandwich structure was optimized, and the best result was obtained when the order was… More >

  • Open Access

    ARTICLE

    Static Analysis of Anisotropic Doubly-Curved Shell Subjected to Concentrated Loads Employing Higher Order Layer-Wise Theories

    Francesco Tornabene*, Matteo Viscoti, Rossana Dimitri

    CMES-Computer Modeling in Engineering & Sciences, Vol.134, No.2, pp. 1393-1468, 2023, DOI:10.32604/cmes.2022.022237

    Abstract In the present manuscript, a Layer-Wise (LW) generalized model is proposed for the linear static analysis of doublycurved shells constrained with general boundary conditions under the influence of concentrated and surface loads. The unknown field variable is modelled employing polynomials of various orders, each of them defined within each layer of the structure. As a particular case of the LW model, an Equivalent Single Layer (ESL) formulation is derived too. Different approaches are outlined for the assessment of external forces, as well as for non-conventional constraints. The doubly-curved shell is composed by superimposed generally anisotropic laminae, each of them characterized… More >

  • Open Access

    ARTICLE

    Static Analysis of Doubly-Curved Shell Structures of Smart Materials and Arbitrary Shape Subjected to General Loads Employing Higher Order Theories and Generalized Differential Quadrature Method

    Francesco Tornabene*, Matteo Viscoti, Rossana Dimitri

    CMES-Computer Modeling in Engineering & Sciences, Vol.133, No.3, pp. 719-798, 2022, DOI:10.32604/cmes.2022.022210

    Abstract The article proposes an Equivalent Single Layer (ESL) formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions. A parametrization of the physical domain is provided by employing a set of curvilinear principal coordinates. The generalized blending methodology accounts for a distortion of the structure so that disparate geometries can be considered. Each layer of the stacking sequence has an arbitrary orientation and is modelled as a generally anisotropic continuum. In addition, re-entrant auxetic three-dimensional honeycomb cells with soft-core behaviour are considered in the model. The unknown variables are described employing a… More > Graphic Abstract

    Static Analysis of Doubly-Curved Shell Structures of Smart Materials and Arbitrary Shape Subjected to General Loads Employing Higher Order Theories and Generalized Differential Quadrature Method

  • Open Access

    ARTICLE

    Flexible Strain Sensor Based on 3D Electrospun Carbonized Sponge

    He Gong1,2,3, Zilian Wang1,3, Zhiqiang Cheng4, Lin Chen1,3, Haohong Pan1,3, Daming Zhang2, Tianli Hu1,3,*, Thobela Louis Tyasi5

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 4971-4980, 2022, DOI:10.32604/cmc.2022.029433

    Abstract Flexible strain sensor has attracted much attention because of its potential application in human motion detection. In this work, the prepared strain sensor was obtained by encapsulating electrospun carbonized sponge (CS) with room temperature vulcanized silicone rubber (RTVS). In this paper, the formation mechanism of conductive sponge was studied. Based on the combination of carbonized sponge and RTVS, the strain sensing mechanism and piezoresistive properties are discussed. After research and testing, the CS/RTVS flexible strain sensor has excellent fast response speed and stability, and the maximum strain coefficient of the sensor is 136.27. In this study, the self-developed CS/RTVS sensor… More >

  • Open Access

    ARTICLE

    Harmonics Extraction Scheme for Power Quality Improvement Using Chbmli-Dstatcom Module

    R. Hemalatha1,*, M. Ramasamy2

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1505-1525, 2023, DOI:10.32604/iasc.2023.026301

    Abstract In recent day’s power distribution system is distress from acute power quality issues. In this work, for compensating Power Quality (PQ) disturbances a seven level cascaded H-bridge inverter is implemented in distribution static compensator which protects power quality problems in currents. Distribution Static Compensator (DSTATCOM) aid to enhances power factor and removes total harmonic distortion which is drawn from non-linear load. The D–Q reference theory based hysteresis current controller is employed to generate reference current for compensation of harmonics and reactive power, additionally Probabilistic Neural Network (PNN) classifier is used which easily separates exact harmonics. In the meantime fuzzy logic… More >

  • Open Access

    ARTICLE

    Research on Dynamic and Static Test Methods for Evaluating the Poisson’s Ratio of Oriented Strand Board

    Yuhao Zhou, Yuhang He, Zhaoyu Shen, Zheng Wang*

    Journal of Renewable Materials, Vol.10, No.12, pp. 3459-3476, 2022, DOI:10.32604/jrm.2022.021251

    Abstract In this article, dynamic method and static method of testing Poisson’s ratio of OSB (Oriented Strand Board) were proposed. Through modal and static numerical analyses, the position where the transverse stress is equal to zero was determined. The binary linear regression method was applied to express the gluing position of the strain gauge as a relational expression that depended on the length-width ratio and width-thickness ratio of the cantilever plate. Then the longitudinal and transverse Poisson’s ratios of OSB were measured by the given dynamic and static methods. In addition, the test results of OSB Poisson’s ratio were analyzed with… More >

  • Open Access

    ARTICLE

    Numerical Simulation Research on Static Aeroelastic Effect of the Transonic Aileron of a High Aspect Ratio Aircraf

    Hongtao Guo, Changrong Zhang, Binbin Lv, Li Yu*

    CMES-Computer Modeling in Engineering & Sciences, Vol.132, No.3, pp. 991-1010, 2022, DOI:10.32604/cmes.2022.020638

    Abstract The static aeroelastic effect of aircraft ailerons with high aspect ratio at transonic velocity is investigated in this paper by the CFD/CSD fluid-structure coupling numerical simulation. The influences of wing static aeroelasticity and the ‘scissor opening’ gap width between aileron control surface and the main wing surface on aileron efficiency are mainly explored. The main purpose of this paper is to provide technical support for the wind tunnel experimental model of aileron static aeroelasticity. The results indicate that the flight dynamic pressure has a great influence on the static aeroelastic effect of ailerons, and the greater the dynamic pressure, the… More >

  • Open Access

    ARTICLE

    OLFM4 Inhibits Epithelial–Mesenchymal Transition and Metastatic Potential of Cervical Cancer Cells

    Juan Li*†1, Chunyan Liu‡1, Dawei Li§, Meng Wan, Hong Zhang, Xiaoxia Zheng, Xuemei Jie, Pengju Zhang, Jingjing Li#, Hongchun Hou, Qing Sun*

    Oncology Research, Vol.27, No.7, pp. 763-771, 2019, DOI:10.3727/096504018X15399955297355

    Abstract OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened by phosphatidic acid (PA)-induced mTOR signal activation, which implicates the… More >

  • Open Access

    ARTICLE

    Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study

    Xiaoting Wei, Lili Mao, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Yan Kong, Jie Dai, Xuan Wang, Siming Li, Bixia Tang, Bin Lian, Xieqiao Yan, Xue Bai, Li Zhou, Jun Guo, Lu Si

    Oncology Research, Vol.27, No.4, pp. 495-501, 2019, DOI:10.3727/096504018X15331163433914

    Abstract Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment is a promising approach in treating advanced melanoma patients harboring c-Kit mutations or amplifications. We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring c-Kit mutations or amplifications. These patients were treated with imatinib at a dose of 400 mg/day continuously unless intolerable toxicities or disease progression occurred. Endpoints for exploration included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease of control rate (DCR). The median OS and PFS of all patients were 13.1 and 4.2 months,… More >

  • Open Access

    ARTICLE

    Cost–Utility Analysis of Pembrolizumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small Cell Lung Cancer With Different PD-L1 Expression Levels

    Xiuhua Weng*1, Shaohong Luo*1, Shen Lin*, Lixian Zhong, Meiyue Li*, Rao Xin*, Pinfang Huang*, Xiongwei Xu*

    Oncology Research, Vol.28, No.2, pp. 117-125, 2020, DOI:10.3727/096504019X15707883083132

    Abstract To evaluate the cost–utility of pembrolizumab versus chemotherapy as the first-line setting for metastatic nonsmall cell lung cancer (NSCLC) from the US health care system perspective, a Markov model was developed to compare the lifetime cost and effectiveness of pembrolizumab versus chemotherapy for untreated metastatic NSCLC, based on the clinical data derived from phase III randomized controlled trial (KEYNOTE- 042; ClinicalTrials.gov; NCT02220894). Weibull distribution was fitted to simulate the parametric survival functions. Drug costs were collected from official websites, and utility values were obtained from published literature. Total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) were computed… More >

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