JIYUN PANG^1,2,#, WEIGANG XIU^1,#, YUEYUN CHEN⁴, WENJING LIAO^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.33, No.4, pp. 895-904, 2025, DOI:10.32604/or.2024.053363 - 19 March 2025

Abstract Background: Non-small cell lung cancer (NSCLC) is often accompanied by brain metastasis (BM), and the prognosis of patients with BM is poor. This study assesses the prognostic impact of BM in NSCLC patients with epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively evaluated 692 advanced NSCLC patients with EGFR mutations treated with tyrosine kinase inhibitors (TKIs) at West China Hospital from 2015 to 2019. The overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), disease control rate (DCR), and clinical parameters of the BM and non-BM groups were compared. Univariable and multivariable… More >

Chang-Eui Hong¹, Su-Yun Lyu^2,*

BIOCELL, Vol.49, No.2, pp. 289-314, 2025, DOI:10.32604/biocell.2025.061334 - 28 February 2025

Abstract Objectives: Among cutaneous malignancies, melanoma stands out for its particularly aggressive nature, with therapeutic interventions becoming notably limited once the disease progresses. In this research, we investigate the tumor-suppressing capabilities of water-extracted Korean mistletoe (Viscum album var. coloratum) and its purified lectin component (V. album var. coloratum agglutinin, VCA) using two distinct mouse melanoma models: B16BL6 and B16F10 cell lines. Methods: The impact of water extract and VCA treatments on melanoma cells was assessed through multiple experimental approaches, examining cellular survival rates, programmed cell death pathways, multicaspase activity, and cell cycle distribution patterns. To elucidate the interconnections among… More >

Ömer Ekim Genel^*, Hilal Koç, Ekrem Tüfekci

CMC-Computers, Materials & Continua, Vol.82, No.2, pp. 2043-2059, 2025, DOI:10.32604/cmc.2025.060111 - 17 February 2025

Abstract Due to their superior properties, the interest in nanostructures is increasing today in engineering. This study presents a new two-noded curved finite element for analyzing the in-plane static behaviors of curved nanobeams. Opposite to traditional curved finite elements developed by using approximate interpolation functions, the proposed curved finite element is developed by using exact analytical solutions. Although this approach was first introduced for analyzing the mechanical behaviors of macro-scale curved beams by adopting the local theory of elasticity, the exact analytical expressions used in this study were obtained from the solutions of governing equations that… More >

Zhao-Jun Zhang¹, Wen-Wei Wang^1,2,*, Jing-Shui Zhen¹, Bo-Cheng Li¹, De-Cheng Cai¹, Yang-Yang Du¹, Hui Huang²

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 105-123, 2025, DOI:10.32604/sdhm.2024.052506 - 15 November 2024

Abstract This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer (GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone. An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs, and a calculation method based on the conjugate beam method was proposed. The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens. Two methods, epoxy resin bonding, and stud connection, were used to connect the composite… More >

Aalya Hamouda¹, Ahmed Ibrahim², Nicholas Corsi³, Giampaolo Siena⁴,Dean S. Elterman⁵, Bilal Chughtai⁶, Naeem Bhojani², Francesco Sessa⁴, Anna Rivetti⁴, Silvia Secco⁷, Kevin C. Zorn^2,8

Canadian Journal of Urology, Vol.31, No.1, pp. 11802-11808, 2024

Abstract Minimally invasive surgery techniques (MIST) have become newly adopted in urological care. Given this, new analgesic techniques are important in optimizing patient outcomes and resource management. Rez ūm treatment (RT) for BPH has emerged as a new MIST with excellent patient outcomes, including improving quality of life (QoL) and International Prostate Symptom Scores (IPSSs), while also preserving sexual function. Currently, the standard analgesic approach for RT involves a peri prostatic nerve block (PNB) using a transrectal ultrasound (TRUS) or systemic sedation anesthesia. The TRUS approach is invasive, uncomfortable, and holds a risk of infection. Additionally,… More >

Agustín Pérez-Londoño, Alejandro Abello, Boris Gershman, Ruslan Korets

Canadian Journal of Urology, Vol.31, No.2, pp. 11848-11853, 2024

Abstract Holmium laser enucleation of the prostate (HoLEP) is considered a size-independent technique to treat benign prostatic hyperplasia. This safe and effective procedure is increasingly being adopted in urology training programs worldwide, yet limited teaching strategies have been described. Endoscopic handling during HoLEP allows for a simultaneous interaction between the surgeon and trainee, facilitating a guided teaching strategy with increasing difficulty as experience grows. In this article, we describe our stepwise approach for teaching HoLEP as part of a structured surgical training curriculum. We also evaluate the association of our method with intraoperative efficiency parameters and More >

Bruce M. Gao, Seyedamirvala Saadat, Edward J. H. Choi, James Jiang, Akhil K. Das

Canadian Journal of Urology, Vol.31, No.3, pp. 11904-11907, 2024

Abstract Holmium enucleation of the prostate (HoLEP) is a gold standard, size-independent surgical treatment for benign prostatic hyperplasia (BPH) distinguished for its efficacy in tissue removal, shorter catheterization durations, lower transfusion rates, and decreased hospital stays when compared to transurethral resection of the prostate (TURP). The objective of this article is to demonstrate the step-by-step procedure of holmium laser cystolitholapaxy and enucleation of the prostate for BPH, emphasizing a top-down modified two-lobe technique with early apical release which enhances visualization and irrigation flow during the enucleation process. More >

Nikola C. Teslovich¹, Peter Elliott², Christopher S. Elliott²

Canadian Journal of Urology, Vol.31, No.3, pp. 11886-11891, 2024

Abstract Introduction: To define the smallest prostate needle biopsy (PNB) template necessary for accurate tissue diagnosis in men with markedly elevated PSA while decreasing procedural morbidity.
Materials and methods: We performed a chart review of 80 men presenting with a newly elevated PSA > 100 ng/mL who underwent biopsy (PNB or metastatic site). For patients who underwent a full 12-core biopsy, simulated templates of 2- to 10-cores were generated by randomly drawing subsets of biopsies from their full-template findings. Templates were iterated to randomize core location and generate theoretical smaller template outcomes. Simulated biopsy results were compared to… More >

Jean-Baptiste Lattouf¹, Jenny J. Ko², Margot K. Davis³, Christian Constance⁴, Geoffrey T. Gotto⁵

Canadian Journal of Urology, Vol.31, No.5, pp. 11977-11985, 2024

Abstract Introduction: Niraparib, a PARP1/2 inhibitor, is newly approved in combination with abiraterone acetate (AA) plus prednisone or prednisolone (niraparib/AA+P) for the treatment of adult patients with BRCA-mutated, treatment-naïve metastatic castration resistant prostate cancer (mCRPC). Detailed guidance beyond the prescribing information may be helpful in managing the side effect profile and dosing practicalities of this combination therapy.
Materials and methods: A panel of specialists convened to design management algorithms for four common niraparib/ AA+P treatment-related adverse events (AEs) in mCRPC; anemia, thrombocytopenia, hypertension, and nausea. The algorithms build on Health Canada-approved prescribing information to highlight practical considerations related… More >

Gabrielle R. Yankelevich¹, Kale Moreland², Makayla M. Swancutt², Robert L. Grubb¹

Canadian Journal of Urology, Vol.31, No.6, pp. 12035-12044, 2024

Abstract Introduction: We report the first scoping review of the clinical urologic literature for photodynamic therapy (PDT) among multiple urologic malignancies.
Materials and methods: A scoping review using Medline and Embase was performed for treatment of urologic malignancies with PDT.
Results: There were 84 papers included with the majority involving bladder and prostate cancer. Upper tract urothelial cancer (UTUC) only comprised three publications and there was no clinical data for renal or testicular cancer. Utilizing PDT in prostate cancer led to a negative biopsy rate of 30%-100%. Bladder cancer treatment with PDT had a 3-month complete response rate of More >