R. Canabarro^1,2, H. Sporleder², T. Gomes^3,4, G. Zanatta^3,5, L. Scribel^3,6, F. Freitas⁷, J. Neumann², P. Pranke^1,3

BIOCELL, Vol.31, No.3, pp. 397-403, 2007, DOI:10.32604/biocell.2007.31.397

Abstract The use of umbilical cord blood stem cells is an efficient alternative for the transplantation of hematopoietic progenitor cells. A number of factors can influence the volume and amount of CD34⁺ cells, which are considered as immature and capable of proliferation. Quantification of CD34⁺ cells, evaluation of CD38 and c-kit molecules on these cells, as well as correlations of such factors as maternal age, gestational age, newborn sex and weight, umbilical cord length, placental weight with increased volume and concentration of immature cells, among others, were performed in 70 blood samples from term newborns. The mean volume of umbilical cord… More >

Danyang Yue¹, Yijuan Fan¹, Juan Lu¹, Mengxue Zhang¹, Jin Zhou¹, Yuying Bai¹, Jun Pan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 144-144, 2019, DOI:10.32604/mcb.2019.07084

Abstract Mesenchymal Stem Cells (MSCs) are recruited to the musculoskeletal system following trauma [1] or chemicals stimulation [2]. The regulation of their differentiation into either bone or cartilage cells is a key question. The fluid shear stress (FSS) is of pivotal importance to the development, function and even the repair of all tissues in the musculoskeletal system [3]. We previously found that MSCs are sensitive enough to distinguish a slight change of FSS stimulation during their differentiation commitment to bone or cartilage cells, and the internal mechanisms. In detail, MSCs were exposed to laminar FSS linearly increased from 0 to 10… More >

Pan Zhang^1,2, Chen Zhang^1,2, Jiyang Han^1,2, Xiru Liu^1,2, Qishan Wang³, Hui Yang^1,2,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 132-132, 2019, DOI:10.32604/mcb.2019.06839

Abstract Research in stem cell biology relies on the knowledge of the cell microenvironment in vivo, known as “stem cell niche”, where stem cells are nurtured by the niche signals. Hematopoietic stem cells (HSCs) are capable of continuously generating and maintaining the body’s full immune and hematopoietic systems. In adult, a pool of hematopoietic cells, including HSCs, primarily reside in the bone marrow (BM) niches that plays critical roles on cell fate. Niche supporting cells, cytokines, extracellular matrix proteins and other biochemical cues associated with HSCs behaviors (quiescence, self-renewal, proliferation, differentiation, mobilization, homing, and apoptosis) has been revealed in quantity. Recently… More >

Mengyue Wang¹, Runze Zhao¹, Fan Feng¹, Tingting Xia^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 130-130, 2019, DOI:10.32604/mcb.2019.07154

Abstract Hepatocellular carcinoma (HCC) is the third most common cancer in the world. Previous studies have shown that hard matrix promotes the proliferation of liver tumor cells. However, the role of matrix stiffness on hepatic cancer stem cells (HCSCs) is still unclear. Three-dimensional hydrogels with different stiffness were used to mimic the normal liver tissue (4kPa) and cancerous liver tissue (26kPa) stiffness. The proliferation, stemness and invasion properties of HCSCs under 3D different stiffness were detected. METHOD: HSCSs were screened and cultured by enrichment method, and the effect of matrix stiffness on HCSCs was studied by three-dimensional culture of HCSCs in… More >

Yuhsuan Wang^1,2, Yuwei Guo^1,2, Lisha Zheng^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 99-99, 2019, DOI:10.32604/mcb.2019.06995

Abstract Many studies have shown that cell shape effects cell chromatin aggregation, gene expression, protein synthesis, cell growth, apoptosis, and cytoskeletal rearrangement [1, 2]. Dental pulp stem cells (DPSCs) are capable of osteogenic, dentinogenic, chondrogenic, and neurogenic differentiation. They are regarded as a promising candidate for tissue regeneration. How the cell shape regulates their cell behavior is still unknown. We used micropatterning technology to design single cell patterns in a 1:1, 1:2, 1:4, 1:8, 1:16 length-width ratio of rectangles with the same area. The results indicated that cell shape rearranged the cytoskeleton of DPSCs. The nuclear shape also affected by different… More >

Lili Dong¹, Yang Song^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 78-78, 2019, DOI:10.32604/mcb.2019.07130

Abstract It has been widely recognized that stem cells possess the potential of osteogenic differentiation, which greatly contribute to bone repair. Recently, accumulating evidences have indicated that mechanical cues are required for bone repair ^[1,2]. However, how local and recruited stem cells in the bone architecture receive the mechanical signals is poorly understood ^[3,4]. The purpose of this study is to demonstrate that macrophages potentially transduce the mechanical signals for stem cell osteogenic lineage. This demonstration has been carried out through a co-culture system to investigate the effect of macrophages which subjected to cyclic stretch on the osteogenic potential of bone… More >

Diego Masone^1,2, Aldana D. Gojanovich¹, Yesica R. Frontini-Lopez¹, Samanta DEL Veliz¹, Marina Uhart¹, Diego M. Bustos^1,3*

BIOCELL, Vol.41, No.2-3, pp. 55-58, 2017, DOI:10.32604/biocell.2017.41.055

Abstract In this study, we propose an automatic procedure for digital image processing. We describe a method that can efficiently quantify and characterize lipid droplets distributions in different cell types in culture. Prospectively, the lipid droplets detection method described in this work could be applied to static or time-lapse data, collected with a simple visible light or fluorescence microscopy equipment. Fully automated algorithms were implemented in Octave, a freely available scientific package. More >

S. Sun¹, S. Lipsky¹, M. Cho¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 213-213, 2006, DOI:10.32604/mcb.2006.003.213

Abstract This article has no abstract. More >

F. Li¹, X. Wang¹, X. Liao¹, C. Niyibizi¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 167-168, 2006, DOI:10.32604/mcb.2006.003.167

Abstract This article has no abstract. More >

E. K. Moioli¹, B. Shah¹, P. A. Clark¹, M. Stroscio¹, J. J. Mao¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 153-155, 2006, DOI:10.32604/mcb.2006.003.153

Abstract This article has no abstract. More >