I. A. Titushkin¹, M. Cho¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 151-151, 2006, DOI:10.32604/mcb.2006.003.151

Abstract This article has no abstract. More >

C. Niyibizi¹, F. Li¹, X. Wang¹, X. Liao¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 149-149, 2006, DOI:10.32604/mcb.2006.003.149

Abstract This article has no abstract. More >

Entsar A. SAAD¹, Reda S. EL-DEMERDASH², Eman M. ABD EI-FATTAH¹

BIOCELL, Vol.43, No.2, pp. 73-80, 2019, DOI:10.32604/biocell.2019.07020

Abstract Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function tests. Rats treated with cisplatin + captopril showed noticeable kidney histopathological changes. Superior… More >

HAIFENG WANG^1,2, KAI WANG¹, JUAN GUO¹, TIEQIAO WEN²

BIOCELL, Vol.43, No.2, pp. 59-64, 2019, DOI:10.32604/biocell.2019.05731

Abstract Histone deacetylation is a key modulator involved in cell proliferation, apoptosis, and mRNA transcription. However, the effects of histone deacetylation on C17.2 neural stem cells (NSCs) remain unclear. Here, the histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) were used to determine the role of histone deacetylation on gene transcription in NSCs. The results showed that the mRNA expression of p53, Sox1, Sox2, and Bax were significantly higher in E14.5 NSCs than in C17.2 NSCs. Nestin, a marker gene of neuronal differentiation, did not differ significantly between E14.5 NSCs and C17.2 NSCs. The transcription levels of p53 and Nestin were… More >

Nesrine EBRAHIM¹, Eman EHSAN², Eman Abd EL GHANY², Dina SABRY³, Ashraf SHAMAA⁴

BIOCELL, Vol.43, No.1, pp. 21-28, 2019, DOI:10.32604/biocell.2019.06111

Abstract The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into four groups. Group 1: control group. Group 2: rats were exposed to bilateral ligation of cephalic arteries. Group… More >

Ruikai Chen¹, Delphine Dean^1,*

Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 153-169, 2017, DOI:10.3970/mcb.2017.014.153

Abstract Vascular smooth muscle cells (VSMCs) play an important role in regulating blood flow and pressure by contracting and relaxing in response to a variety of mechanical stimuli. A fully differentiated and functional VSMC should have both the ability to contract and relax in response to environmental stimuli. In addition, it should have the proper mechanical properties to sustain the mechanically active vascular environment. Stem cells can differentiate towards VSMC lineages and so could be used as a potential treatment for vascular repair. However, few studies have assessed the time it takes for stems cells to acquire similar mechanical property to… More >

Maryam Jazayeri¹, Mohammad Ali Shokrgozar¹, Nooshin Haghighipour^1,2, Reza Mahdian³, Mehdi Farrokhi¹, Shahin Bonakdar¹, FereshtehMirahmadi¹, Tannaz Nourizadeh Abbariki

Molecular & Cellular Biomechanics, Vol.12, No.3, pp. 197-213, 2015, DOI:10.3970/mcb.2015.012.197

Abstract The osseous tissue repair and regeneration have great importance in orthopedic and maxillofacial surgery. Tissue engineering makes it possible to cure different tissue abnormalities using autologous grafts. It is now obvious that mechanical loading has essential role in directing cells to differentiation. In this study, the influence of cyclic uniaxial loading and its combination with chemical factors on expression of osteogenic markers was investigated. Rat bone marrow-derived stem cells were isolated and cultured. In one group cells were maintained in chemical induction medium. In another group cells were subjected to cyclic uniaxial strain with 3% amplitude and 0.3 Hz frequency… More >

F. S. Tabatabaei^∗, M. Jazayeri^†, P. Ghahari^‡, N. Haghighipour^§

Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 209-220, 2014, DOI:10.3970/mcb.2014.011.209

Abstract During orthodontic treatments, applied mechanical forces create strain and result in tooth movement through the alveolar bone. This response to mechanical strain is a fundamental biological reaction. The present study evaluated the effect of equiaxial strain within the range of orthodontic forces on the osteogenic differentiation of human dental pulp stem cells (hDPSCs). Following isolation and culture of hDPSCs, 3rd passage cells were transferred on a silicone membrane covered with collagen. Cell adhesion to the membrane was evaluated under scanning electron microscope (SEM). Cells were divided into three groups: the first group was placed in a conventional culture medium, transferred… More >

Norizadeh Abbariki Tannaz^*,†, Shokrgozar Mohammad Ali^†,‡, Haghighipour Nooshin^*,§, Aghdami Nasser^¶, Mahdian Rezak^II, Amanzadeh Amir^*, Jazayeri Maryam^*,†

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 19-37, 2014, DOI:10.3970/mcb.2014.011.019

Abstract Background: Environmental factors affect stem cell differentiation. In addition to chemical factors, mechanical signals have been suggested to enhance myogenic differentiation of stem cells. Therefore, this study was undertaken to illustrate and compare the effect of chemical and mechanical stimuli on Myogenin (MyoG) and Myosin heavy chani 2 (Myh2) expression of mouse bone marrowderived mesenchymal stem cells (BMSCs) and embryonic stem cells (ESCs). Methods: After isolation and expansion of BMSCs and generation of embryoid bodies and spontaneous differentiation of ESCs, cells were examined in 4 groups: (1) control group: untreated cells; (2) chemical group: cells incubated in myogenic medium (5-azacythidine… More >

Syed A Jamal^*

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 267-273, 2013, DOI:10.3970/mcb.2013.010.267

Abstract Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) were subjected to in vitro osteogenic differentiation using a novel combination of signaling molecules including BMP-2 and purmorphamine. Differentiation outcomes were assessed by calcein staining and by microscopic examination of the cytoskeleton. Calcein staining showed appreciable degree of calcium mineralization in cell culture, and changes in the morphological attributes of differentiating cells were observed vis-a-vis the actin cytoskeleton. Finally, positive calcein staining, altered cytoskeletal profile, and stress fiber formation in treated cells demonstrated, for the first time, a potentially synergistic interplay between BMP-2 and the hedgehog agonist, purmorphamine. This study lends support to… More >