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  • Open Access

    ARTICLE

    miR-21-3p alleviates neuronal apoptosis during cerebral ischemiareperfusion injury by targeting SMAD2

    FEI TIAN*, GANG LIU, LINLIN FAN, ZHONGYUN CHEN, YAN LIANG,

    BIOCELL, Vol.45, No.1, pp. 49-56, 2021, DOI:10.32604/biocell.2021.013794

    Abstract Cerebral ischemia is due to the formation of blood clots or embolisms in the brain arteries, which leads to local brain tissue necrosis and neural cell apoptosis. Recent studies have shown that microRNA (miRNA) plays an important regulatory role in the pathological process of ischemic injury. The aim of this study is to investigate the role and the mechanism of miR-21-3p and drosophila mothers against decapentaplegic 2 (SMAD2) in cerebral ischemic reperfusion injured (CIRI) neural cells. The CIRI model was established by oxygen-glucose deprivation and recovery process for N2a cells. The cell viability and the apoptotic was evaluated by MTT… More >

  • Open Access

    ARTICLE

    Dynamic Resistance Parameters of Arm Stroke during Swimming

    Bin Wang1, Dayong Li2, Yuxin Qin3,*

    Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 179-188, 2020, DOI:10.32604/mcb.2020.011050

    Abstract Swimming, as a sport beneficial to body and mind, also has a place in international sports. For swimmers and coaches, it is always the most important to improve the propulsion and reduce the resistance during swimming. This paper briefly introduced the resistance of human body in swimming, described the dynamic resistance of human body in arm stroke, and then introduced the principle of micro disturbance method which was used for measuring the dynamic resistance in swimming. Finally, ten swimmers from school team and ten beginners were tested for the dynamic resistance in freestyle, backstroke and breaststroke when they swam with… More >

  • Open Access

    ARTICLE

    Feature Selection and Representation of Evolutionary Algorithm on Keystroke Dynamics

    Purvashi Baynath, Sunjiv Soyjaudah, Maleika Heenaye-Mamode Khan

    Intelligent Automation & Soft Computing, Vol.25, No.4, pp. 651-661, 2019, DOI:10.31209/2018.100000060

    Abstract The goal of this paper is (i) adopt fusion of features (ii) determine the best method of feature selection technique among ant Colony optimisation, artificial bee colony optimisation and genetic algorithm. The experimental results reported that ant colony Optimisation is a promising techniques as feature selection on Keystroke Dynamics as it outperforms in terms of recognition rate for our inbuilt database where the distance between the keys has been considered for the password derivation with recognition rate 97.85%. Finally the results have shown that a small improvement is obtained by fused features, which suggest that an effective fusion is necessary. More >

  • Open Access

    ARTICLE

    Cerebrovascular accidents in Ebstein’s anomaly

    Nicholas Y. Tan1, Christine H. Attenhofer Jost1, Murray D. Polkinghorne1, Emily R. Vargas2, David O. Hodge2, Joseph A. Dearani3, Samuel J. Asirvatham1,4, Heidi M. Connolly1, Christopher J. McLeod1

    Congenital Heart Disease, Vol.14, No.6, pp. 1157-1165, 2019, DOI:10.1111/chd.12841

    Abstract Introduction: Mechanisms and risk factors for cerebrovascular accidents (CVAs) in Ebstein’s anomaly (EA) are not well understood; hence, we aimed to clarify these in a large cohort of EA patients.
    Methods: Patients with a confirmed diagnosis of EA were retrospectively reviewed. Baseline characteristics were compared between patients with and without a prior history of CVA using logistic regression modeling. Cox regression analysis was used to identify predictors of CVA following initial evaluation. CVA incidence from birth and following tricuspid valve surgery were estimated using the Kaplan‐Meier method.
    Results: Nine hundred sixty‐eight patients (median age 21.1 years, 41.5% male) were included,… More >

  • Open Access

    ARTICLE

    Multifrequency Microwave Imaging for Brain Stroke Detection

    Lulu Wang1,*

    Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 33-40, 2020, DOI:10.32604/mcb.2019.07165

    Abstract CT and MRI are often used in the diagnosis and monitoring of stroke. However, they are expensive, time-consuming, produce ionizing radiation (CT), and not suitable for continuous monitoring stroke. Microwave imaging (MI) has been extensively investigated for identifying several types of human organs, including breast, brain, lung, liver, and gastric. The authors recently developed a holographic microwave imaging (HMI) algorithm for biological object detection. However, this method has difficulty in providing accurate information on embedded small inclusions. This paper describes the feasibility of the use of a multifrequency HMI algorithm for brain stroke detection. A numerical system, including HMI data… More >

  • Open Access

    ABSTRACT

    Multifrequency Microwave Imaging for Brain Stroke Detection

    Lulu Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 125-125, 2019, DOI:10.32604/mcb.2019.07101

    Abstract Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor… More >

  • Open Access

    ABSTRACT

    Protecting the Brain from Calcification in Ischemic Stroke

    Shu Q. Liu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Vibration Fatigue Analysis of Cylinder Head of a New Two-Stroke Free Poston Engine Using Finite Element Approach

    M. M. Rahman1, A. K. Ariffin1, N. Jamaludin1, C. H. C. Haron1

    Structural Durability & Health Monitoring, Vol.1, No.2, pp. 121-130, 2005, DOI:10.3970/sdhm.2005.001.121

    Abstract The focus of this paper is to design a new two-stroke linear generator engine. This paper describes the finite element based vibration fatigue analysis techniques that can be used to predict fatigue life using total life approach. Fatigue damage in traditionally determined from time signals of loading, usually in the form of stress and strain. However, there are scenarios when a spectral form of loading is more appropriate. In this case the loading is defined in terms of its magnitude at different frequencies in the form of a power spectral density (PSD) plot. A power spectral density function is the… More >

  • Open Access

    ARTICLE

    New Concept in Stroke Diagnosis

    Ali. E. Dabiri1,2,*, Richard Leigh3, Ghassan S. Kassab1

    Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 225-233, 2019, DOI:10.32604/mcb.2019.07962

    Abstract Stroke is a life-threatening event that is expected to more than double over the next 40 years. Approximately 85% of strokes are ischemic in nature and result from thromboembolic occlusion of a major cerebral artery or its branches. One of the diagnostic methods for detection of the cerebral ischemia is the gadolinium-enhanced MRI imaging. It is mainly used in patients to detect brain tissue damaged by an ischemic stroke and brain hemorrhage. These techniques are expensive, require sophisticated machines and are time consuming. A recent study in acute stroke patients showed gadolinium leakage into ocular structures (GLOS) during MRI imaging… More >

  • Open Access

    ABSTRACT

    CFD case study to optimize surgical adjustment of ventricular assist device implantation to minimize stroke risk part II: transient vascular resistance model

    Eduardo Divo1, Alain Kassab2, Greisa Mendez3, I. RicardoArgueta-Morales4, William M. DeCampli4,5

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.15, No.4, pp. 125-128, 2010, DOI:10.3970/icces.2010.015.125

    Abstract In order to properly account for the unsteady nature of the flow field generated by the cardiac ejection in an Aortic Arch with an implanted Left Ventricular Assist Device (LVAD) Computational Fluid Dynamics (CFD) model, a closed-loop external vascular model is necessary. Such external model is coupled to the CFD model to dictate the flow field boundary conditions at the outlets of the CFD model and thus, control the flow splits through the different branches that stem out of the aortic arch throughout the cardiac cycle. More >

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