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  • Open Access


    Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death

    Vesna Vetma*†‡, Jan Rožanc§, Emilie M. Charles*†, Christian T. Hellwig*†‡¶, Leonidas G. Alexopoulos§#, Markus Rehm*†‡#

    Oncology Research, Vol.25, No.9, pp. 1489-1494, 2017, DOI:10.3727/096504017X14897145996933

    Abstract Antagonists of inhibitors of apoptosis proteins (IAPs), alone or in combination with genotoxic therapeutics, have been shown to efficiently induce cell death in various solid tumors. The IAP antagonist birinapant is currently being tested in phase II clinical trials. We herein aimed to investigate the antitumor efficacy of dacarbazine in vitro, both as a single agent and in combination with birinapant, in melanoma cell lines. Covering clinically relevant drug concentration ranges, we conducted a total of 5,400 measurements in a panel of 12 human melanoma cell lines representing different stages of disease progression. Surprisingly, functionally More >

  • Open Access


    Enhancing Relational Triple Extraction in Specific Domains: Semantic Enhancement and Synergy of Large Language Models and Small Pre-Trained Language Models

    Jiakai Li, Jianpeng Hu*, Geng Zhang

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2481-2503, 2024, DOI:10.32604/cmc.2024.050005

    Abstract In the process of constructing domain-specific knowledge graphs, the task of relational triple extraction plays a critical role in transforming unstructured text into structured information. Existing relational triple extraction models face multiple challenges when processing domain-specific data, including insufficient utilization of semantic interaction information between entities and relations, difficulties in handling challenging samples, and the scarcity of domain-specific datasets. To address these issues, our study introduces three innovative components: Relation semantic enhancement, data augmentation, and a voting strategy, all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks. We first… More >

  • Open Access


    Emerging Trends in Damage Tolerance Assessment: A Review of Smart Materials and Self-Repairable Structures

    Ali Akbar Firoozi1,*, Ali Asghar Firoozi2

    Structural Durability & Health Monitoring, Vol.18, No.1, pp. 1-18, 2024, DOI:10.32604/sdhm.2023.044573

    Abstract The discipline of damage tolerance assessment has experienced significant advancements due to the emergence of smart materials and self-repairable structures. This review offers a comprehensive look into both traditional and innovative methodologies employed in damage tolerance assessment. After a detailed exploration of damage tolerance concepts and their historical progression, the review juxtaposes the proven techniques of damage assessment with the cutting-edge innovations brought about by smart materials and self-repairable structures. The subsequent sections delve into the synergistic integration of smart materials with self-repairable structures, marking a pivotal stride in damage tolerance by establishing an autonomous More >

  • Open Access



    Ming Zhao* , Yang Tian

    Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-10, 2019, DOI:10.5098/hmt.13.4

    Abstract The field synergy principle and thermal resistance analysis were carried out for the heat transfer enhancement of a chip heat sink. Thermal analysis of the heat dissipation capacity is applied for setting up the gallery on the rib, changing the fan ventilation diameter, and changing the rib height. The results show that the analysis of field synergy principle agrees well with that of the thermal analysis, and setting up a gallery on the rib can improve the heat capacity of the heat sink. Meanwhile, the results also show that decreasing diameter of the ventilation causes More >

  • Open Access


    Thermogravimetric and Synergy Analysis of the Co-Pyrolysis of Coconut Husk and Laminated Plastic Packaging for Biofuel Production

    Joselito Olalo*

    Energy Engineering, Vol.119, No.2, pp. 555-567, 2022, DOI:10.32604/EE.2022.018864

    Abstract Unlike plastic, biomass can also be converted and produce high quality of biofuel. Co-pyrolysis of coconut husk (CH) and laminated plastic packaging (LPP) were done in this study. Synergy between these two feedstock was calculated by using thermogravimetric (TGA) and derivative thermogravimetry (DTG) analysis. Different activation energies of the reactions in the co-pyrolysis of CH and LPP were evaluated using the Coats-Redfern method. Results showed an activation energy ranging from 8 to 37 kJ/mol in the different percentage composition of the co-pyrolysis. Also, thermal degradation happens in two-stages in the copyrolysis of CH and LPP, More >

  • Open Access


    Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology


    BIOCELL, Vol.46, No.5, pp. 1157-1162, 2022, DOI:10.32604/biocell.2022.018960

    Abstract Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within “stem cell” populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with in vivo lineage-tracing approaches, with an emphasis on practical considerations More >

  • Open Access


    Numerical Analysis on Multi-Field Characteristics and Synergy in a Large-Size Annular Combustion Chamber with Double Swirlers

    Zaiguo Fu1, *, Huanhuan Gao1, Zhuoxiong Zeng1, Jiang Liu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.3, pp. 805-830, 2020, DOI:10.32604/cmes.2020.08825

    Abstract In order to comprehensively evaluate the flow and heat transfer performance of a large-size annular combustion chamber of a heavy-duty gas turbine, we carried out numerical computation and analyses on the velocity, temperature and pressure fields in the chamber with double swirlers. The mathematical model of the coupling combustion, gas flow, and heat transfer process was established. The influences of the inlet swirling strength, fuel-air ratio and temperature of the premixed gas on the multi-field characteristics and synergy were investigated on the basis of field synergy theory. The results showed that the central recirculation zone… More >

  • Open Access


    In Vitro Studies of the Synergy Between Mechanical Loading and Genetics Within Human Induced Pluripotent Stem Cell Derived Micro-Scale Engineered Heart Tissues

    Nathaniel Huebsch1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 107-108, 2019, DOI:10.32604/mcb.2019.08524

    Abstract This article has no abstract. More >

  • Open Access


    Lattice Boltzmann Method Simulation of Channel Flow with Square Pillars inside by the Field Synergy Principle

    Cha’o-Kuang Chen1, Shing-Cheng Chang1, Szu-Yu Sun1

    CMES-Computer Modeling in Engineering & Sciences, Vol.22, No.3, pp. 203-216, 2007, DOI:10.3970/cmes.2007.022.203

    Abstract In this study, the channel flow is discussed by the LBM simulations. In the cases of channel with obstacles inside, the square pillars play the role of causing interruption within the fluid field, and hence change the direction of fluid flow. The recirculation region is formed behind the obstacles and influences the fluid passed through not only in the velocity field but also in the temperature field. Therefore, heat transfer is enhanced in local region.
    The field synergy principle is applied in the research to demonstrate that the increased interruption within the fluid increases the More >

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