Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Agit Amrullah, Ferda Ernawan^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-16, 2026, DOI:10.32604/cmc.2025.069229 - 09 December 2025

Abstract This paper proposes a tamper detection technique for semi-fragile watermarking using Quantization-based Discrete Cosine Transform (DCT) for tamper localization. In this study, the proposed embedding strategy is investigated by experimental tests over the diagonal order of the DCT coefficients. The cover image is divided into non-overlapping blocks of size 8 × 8 pixels. The DCT is applied to each block, and the coefficients are arranged using a zig-zag pattern within the block. In this study, the low-frequency coefficients are selected to examine the impact of the imperceptibility score and tamper detection accuracy. High accuracy of… More >

Qiuling Wu^1,*, Hao Li¹, Mingjian Li¹, Ming Wang²

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-20, 2026, DOI:10.32604/cmc.2025.068220 - 10 November 2025

Abstract Digital watermarking technology plays an important role in detecting malicious tampering and protecting image copyright. However, in practical applications, this technology faces various problems such as severe image distortion, inaccurate localization of the tampered regions, and difficulty in recovering content. Given these shortcomings, a fragile image watermarking algorithm for tampering blind-detection and content self-recovery is proposed. The multi-feature watermarking authentication code (AC) is constructed using texture feature of local binary patterns (LBP), direct coefficient of discrete cosine transform (DCT) and contrast feature of gray level co-occurrence matrix (GLCM) for detecting the tampered region, and the… More >

Rawabi S. Altuwayjiri, Ibtesam S. Almami^*

Oncology Research, Vol.33, No.12, pp. 3923-3943, 2025, DOI:10.32604/or.2025.070104 - 27 November 2025

Abstract Objective: Testicular germ cell tumors (TGCTs) represent the most common malignancy among young men aged 20–40 years. Transglutaminase 7 (TG7), encoded by TGM7, is a poorly characterized enzyme whose function in TGCT remains unknown. This study aimed to assess TG7 expression in clinical specimens and investigate its functional role in a testicular germ cell tumor cell line (NT2/D1). Methods: TG7 protein expression was evaluated in clinical testicular tissue samples via immunohistochemistry (IHC) and immunofluorescence (IF). Functional analysis was conducted in the NT2/D1 human testicular cancer cell line using Dicer-substrate small interfering RNAs (DsiRNAs) targeting TG7. Gene… More >

Apri Heri Iswanto^1,2,*, Nabila Nabila¹, Rika Elfina¹, Luthfi Hakim^1,2, Tito Sucipto^1,2, Manggar Arum Aristri³, Muhammad Adly Rahandi Lubis⁴, Widya Fatriasari⁴, Jajang Sutiawan⁴, Atmawi Darwis⁵, Tomasz Rogoziński⁶, Lee Seng Hua⁷, Lum Wei Chen⁸, Petar Antov⁹

Journal of Renewable Materials, Vol.13, No.11, pp. 2253-2279, 2025, DOI:10.32604/jrm.2025.02025-0058 - 24 November 2025

Abstract Indonesia, with its vast forested regions, has experienced significant deforestation, adversely affecting the wood industry. As a result, alternative sources of lignocellulosic biomass are required to mitigate this impact. Among the abundant lignocellulosic raw materials in Indonesia, particularly in Sumatra, bamboo stands out as a promising substitute. Bamboo is a highly versatile resource, suitable for various applications, including its use as a composite raw material to replace traditional wood-based products. This research work aimed to investigate and evaluate the characteristics—morphology, anatomy, physical and mechanical properties, chemical composition, starch content, and natural resistance—of three bamboo species:… More >

Abdulbari Bener^1,2,*, Ünsal Veli Üstündağ³, Emir Barışık⁴, Cem Cahit Barışık⁵

Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025

Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

Ceren Ayşe Bayram^*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3283-3295, 2025, DOI:10.32604/phyton.2025.073047 - 29 October 2025

Abstract In semi-arid regions where climatic limitations hinder open-field vegetable production, greenhouse-based lettuce (Lactuca sativa L.) cultivation plays a vital role in ensuring off-season supply. In this study, the potential of sustainable input combinations was evaluated to enhance lettuce productivity, quality, and profitability under unheated greenhouse conditions in Southeastern Türkiye. Treatments included farmer practice and a mycorrhizal biofertilizer (ERS, a water-soluble arbuscular mycorrhizal fungus product) applied alone or in combination with organic-based biostimulants (IS and NM). Evaluated parameters were plant height, leaf pigmentation (a*, h°), SPAD values, vitamin C, nitrogen and phosphorus content, and gross margin. The More >

Junyi Xiang^1,2,3, Yijun Chai^1,2,3,*, Xiongwei Yang^1,2,3, Yueming Li^1,2,3

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.011738

Abstract Acoustic metamaterials have garnered significant attention in recent years due to their potential to manipulate sound waves and the ability to dynamically adjust the bandgap of such materials is particularly crucial.
This work investigates the influence mechanisms of solid-liquid phase change processes on the performance of metamaterials, which is a significant research focus in the field of acoustic metamaterials. The primary objective is to explore the mechanisms governing the controllable shifting of bandgaps through phase change processes. By utilizing solid-liquid phase change materials as scattering bodies, numerical methods were employed to calculate the band structure and… More >

Zhenyu Li¹, Hongze Li², Jinshui Yang², Hong Hu^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.010548

Abstract The urgent need to achieve "carbon neutrality" drives the development of innovative porous structures that integrate both acoustic and mechanical properties, aimed at reducing energy consumption. However, enhancing these functionalities often results in increased structural weight, which can restrict their application in scenarios where weight is a critical factor. In response to this challenge, we present a groundbreaking structural design that combines carbon fiber reinforced polymer (CFRP) composites with mechanical and acoustic metamaterials for the first time. This novel construction is characterized by its lightweight nature while delivering exceptional mechanical strength and acoustic performance.
The experimental… More >

Yifan Zhu^1,2, Fengxiang Xu^1,2,*, Zhen Zou^1,2, Zhengpao Liu^1,2, Xiaokun Dai^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-2, 2025, DOI:10.32604/icces.2025.010641

Abstract Conventional energy-absorbing mechanical metamaterials primarily dissipate energy through irreversible plastic deformation, buckling, or fragmentation. Their applications are limited by structural fractures caused by 45° shear stresses and their suitability only for single-use impact protection, lacking the capability for repeated energy absorption. Inspired by the cancellous bone of the human skull, a Tangent Arc Curve Structure (TACS) was proposed in this study, followed by the modeling and fabrication of four types of 3D-TACSs: tensile, tensile-rotational, orthogonal, and diagonal. The shear resistance and repeatable energy absorption capabilities of TACS were systematically investigated through theoretical analysis, compression experiments,… More >