GUANQIONG HU¹, RISHENG HUANG², LUELUE LU¹, QINSHI PAN³, XIAOXIN CHEN^1,*

BIOCELL, Vol.47, No.6, pp. 1243-1251, 2023, DOI:10.32604/biocell.2023.027763

Abstract Background: Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that plays a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). While previous studies have revealed a cross-talk between vitamin D and TGF-β1 signaling, it is still unclear how they interact with each other to regulate the progression of IPF. Methods: In this work, we searched for a novel mediator of TGF-β1 activity in lung fibroblasts and examined its regulation by vitamin D. In addition, we investigated the mechanism underlying the interaction between vitamin D and TGF-β1 signaling in lung fibroblast activation. Bioinformatic analysis was performed to identify TGF-β1… More >

Xingyu Chen^*

Journal of Information Hiding and Privacy Protection, Vol.4, No.2, pp. 103-113, 2022, DOI:10.32604/jihpp.2022.039766

Abstract With the popularization of high-performance electronic imaging equipment and the wide application of digital image editing software, the threshold of digital image editing becomes lower and lower. This makes it easy to trick the human visual system with professionally altered images. These tampered images have brought serious threats to many fields, including personal privacy, news communication, judicial evidence collection, information security and so on. Therefore, the security and reliability of digital information has been increasingly concerned by the international community. In this paper, digital image tamper detection methods are classified according to the clues that they rely on, detection methods… More >

OMER ERDOGAN¹, GULEN MELIKE DEMIRBOLAT², OZGE CEVIK^1,*

BIOCELL, Vol.47, No.5, pp. 1051-1063, 2023, DOI:10.32604/biocell.2023.028129

Abstract Background: Raloxifene, a selective estrogen receptor modulator, is also known to be a lysosomotropic agent. The bioavailability of raloxifene is around 2% due to extensive hepatic transport. Exosomes are nanosized vesicles that are naturally released from cells. Method: In this study, exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability, and an aptamer was attached to the exosome membrane for targeting only HeLa cells. Characterization of exosomes isolated from HeLa cells was performed by transmission electron microscopy, zeta sizer, and western blotting. In addition, the cytotoxic, apoptotic, autophagic, and lysosomotropic effects of the prepared… More >

VIJAY KUMAR^1,#, PRAVEEN C. RAMAMURTHY^2,#, SIMRANJEET SINGH^2,#, DALJEET SINGH DHANJAL³, PARUL PARIHAR⁴, DEEPIKA BHATIA⁵, RAM PRASAD^6,*, JOGINDER SINGH^7,*

BIOCELL, Vol.47, No.5, pp. 1159-1176, 2023, DOI:10.32604/biocell.2023.022065

Abstract Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese Medicines. For several decades, the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, anemia, anorexia, and dyspepsia. In the traditional system, Indian gooseberry has various ethnomedicinal applications. In the Ayurvedic system, different methods of administration (anupan) have shown different ethnomedicinal properties of Indian gooseberry. Seventy well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation, among which the flavonoids and phenols are most prominent. From the toxicity perspective, it is considered a… More >

Liefei Pei^1,2, Xiangyun Zhang¹, Zizhou Yuan^1,*

Journal of Renewable Materials, Vol.11, No.6, pp. 2969-2983, 2023, DOI:10.32604/jrm.2023.025760

Abstract Iron-based amorphous crystalline powder Fe₇₈Si₉B₁₃^AP is used as a permeability reaction barrier (PRB) combined with an electrokinetic method (EK-PRB) to study the removal rate of Cu in contaminated soil. After treating Cucontaminated soil for 5 days under different voltage gradients and soil water content, the soil pH is between 3.1 and 7.2. The increase of voltage gradient and soil water content can effectively promote the movement of Cu²⁺ to the cathode. The voltage gradient is 3 V/cm, and the water content of 40% is considered to be an optional experimental condition. Therefore, under this condition, the effects of Fe₇₈Si₉B₁₃^AP and… More >

V. Jayanthi^*, S. Thenmalar

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3551-3564, 2023, DOI:10.32604/iasc.2023.036599

Abstract In this paper, Modified Multi-scale Segmentation Network (MMU-SNet) method is proposed for Tamil text recognition. Handwritten texts from digital writing pad notes are used for text recognition. Handwritten words recognition for texts written from digital writing pad through text file conversion are challenging due to stylus pressure, writing on glass frictionless surfaces, and being less skilled in short writing, alphabet size, style, carved symbols, and orientation angle variations. Stylus pressure on the pad changes the words in the Tamil language alphabet because the Tamil alphabets have a smaller number of lines, angles, curves, and bends. The small change in dots,… More >

ZEINAB KLAAB¹, AZIZA HASSAN², JAWAHER ALBAQAMI¹, FAIZAH A. ALMALKI^1,*

BIOCELL, Vol.47, No.4, pp. 891-904, 2023, DOI:10.32604/biocell.2023.026556

Abstract Cancer remains to be one of the most severe sicknesses globally. Cases have kept rising over the years. Breast cancer (BC), which is among the leading types of cancers and predominantly affects women, is the second leading cause of cancer mortality. Researchers have developed interventions over the years; however, the BC survival rate has not improved since the 1980s. This has created the need for novel drug interventions that would manage and treat BC more effectively. This study focused on using a combination of natural product extracts such as phytoestrogen (Ziziphus jujube) and Tannin nanoparticles (NP99) together, which we have… More >

YU ZHANG^1,2, XI’AN ZHOU^1,2, CHUNYAN ZHANG^1,2, DENGNI LAI⁵, DONGBO LIU^1,3,4, YANYANG WU^1,2,3,4,*

BIOCELL, Vol.47, No.4, pp. 859-868, 2023, DOI:10.32604/biocell.2023.026429

Abstract Background: Hyperglycemia is a typical symptom of diabetes. High glucose induces apoptosis of islet β cells. While autophagy functions in cytoprotection and autophagic cell death. The interaction between autophagy and apoptosis is important in the modulation of the function of islet β cells. Vitamin B3 can induce autophagy and inhibit islet β apoptosis.Method: The mechanism of vitamin B3-mediated protective effect on the function of islet β cells was explored by the method of western blot, immunofluorescence and flow cytometry.Results: In the present study, high glucose stress increased the apoptosis rate, while vitamin B3 reduced the apoptosis rate. The effect of… More >

YI-NONG CHEN^1,#, YING-LIN CHEN^1,#, WAN-MING CHEN^2,3, MINGCHIH CHEN^2,3, BEN-CHANG SHIA^2,3, JENQ-YUH KO^1,4, SZU-YUAN WU^{2,3,5,6,7,8,9,10,11,*}

Oncology Research, Vol.31, No.1, pp. 23-34, 2023, DOI:10.32604/or.2022.028449

Abstract This study aimed to examine the association between the use of H1-antihistamines (AHs) and head and neck cancer (HNC) risk in patients with type 2 diabetes mellitus (T2DM). Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018. A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression. The results showed that the risk of HNC was significantly lower in AH users (adjusted hazard ratio: 0.55, 95% CI: 0.48 to 0.64) and the incidence rate… More >

Hüseyin Bilal Macit¹, Arif Koyun^2,*

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1603-1619, 2023, DOI:10.32604/cmc.2023.036216

Abstract Recently, digital images have become the most used data, thanks to high internet speed and high resolution, cheap and easily accessible digital cameras. We generate, transmit and store millions of images every second. Most of these images are insignificant images containing only personal information. However, in many fields such as banking, finance, public institutions, and educational institutions, the images of many valuable objects like ID cards, photographs, credit cards, and transaction receipts are stored and transmitted to the digital environment. These images are very significant and must be secured. A valuable image can be maliciously modified by an attacker. The… More >