Manaliben Amin^*

Journal on Artificial Intelligence, Vol.8, pp. 1-18, 2026, DOI:10.32604/jai.2026.073895 - 07 January 2026

Abstract Artificial intelligence (AI) is steadily making its way into pharmaceutical validation, where it promises faster documentation, smarter testing strategies, and better handling of deviations. These gains are attractive, but in a regulated environment speed is never enough. Regulators want assurance that every system is reliable, that decisions are explainable, and that human accountability remains central. This paper sets out a Human-in-the-Loop (HITL) AI approach for Computer System Validation (CSV) and Computer Software Assurance (CSA). It relies on explainable AI (XAI) tools but keeps structured human review in place, so automation can be used without creating… More >

Wu Feng^1,2,*, Tengku Anita Raja Hussin¹, Xu Yang³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

Jianhua Du¹, Shaofeng Wang¹, Ting Gao², Huiwen Sun², Wenjing Liu^1,*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071189 - 08 January 2026

Abstract In ultrasonic non-destructive testing of high-temperature industrial equipment, sound velocity drift induced by non-uniform temperature fields can severely compromise defect localization accuracy. Conventional approaches that rely on room-temperature sound velocities introduce systematic errors, potentially leading to misjudgment of safety-critical components. Two primary challenges hinder current methods: first, it is difficult to monitor real-time changes in sound velocity distribution within a thermal gradient; second, traditional uniform-temperature correction models fail to capture the nonlinear dependence of material properties on temperature and their effect on ultrasonic velocity fields. Here, we propose a defect localization correction method based on… More >

Ping Wu¹, Jie Zou², Wangxin Li^1,*, Yidong Xu¹

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070873 - 08 January 2026

Abstract The existing 2D settlement monitoring systems for utility tunnels are heavily reliant on manual interpretation of deformation data and empirical prediction models. Consequently, early anomalies (e.g., minor cracks) are often misjudged, and warnings lag by about 24 h without automated spatial localization. This study establishes a technical framework for requirements analysis, architectural design, and data-integration protocols. Revit parametric modelling is used to build a 3D tunnel model with structural elements, pipelines and 18 monitoring points (for displacement and joint width). Custom Revit API code integrated real-time sensor data into the BIM platform via an automated… More >

Zhangdi Xie^1,2,*, Cantao Zhuang¹, Yong Wu¹, Linghui Niu¹, Jianming Zhao³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070531 - 08 January 2026

Abstract This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing, as well as from a free-field station and roof frame, during a M_w 5.5 magnitude earthquake in Pingyuan, Shandong, in 2023. The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves. The results indicate that during the earthquake, the peak frequency of the free-field and the measurement points… More >

Renfei Chang¹, Liqiang Jin¹, Haihui Xie^2,*, Kai Zhang³, Musheng Ye⁴

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.063718 - 08 January 2026

Abstract To investigate the impact of temporary structures on the mechanical behavior of shaped bridge towers during the construction process, the Dianbu River Special Bridge was selected as the engineering background. A finite element model of the middle tower column during the construction stage was established using ABAQUS to analyze the effects of key parameters, including the angle and pretension of temporary cables, as well as the wall thickness and diameter of temporary diagonal braces. The study examines how these parameters influence the stresses at the tower-girder consolidation. The results indicate that the angle of temporary More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077268 - 30 December 2025

Abstract This article has no abstract. More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Supriya Wadekar^1,*, Shailendra Mittal¹, Ganesh Wakte², Rajshree Shinde²

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.071761 - 27 December 2025

Abstract Rapid evolutions of the Internet of Electric Vehicles (IoEVs) are reshaping and modernizing transport systems, yet challenges remain in energy efficiency, better battery aging, and grid stability. Typical charging methods allow for EVs to be charged without thought being given to the condition of the battery or the grid demand, thus increasing energy costs and battery aging. This study proposes a smart charging station with an AI-powered Battery Management System (BMS), developed and simulated in MATLAB/Simulink, to increase optimality in energy flow, battery health, and impractical scheduling within the IoEV environment. The system operates through… More >