EDMUND CHEUNG SO^1,2,#, LOUIS W. C. CHOW^3,#, CHIN-MIN CHUANG⁴, CING YU CHEN^5,6, CHENG-HSUN WU⁷, LIAN-RU SHIAO⁸, TING-TSZ OU⁹, KAR-LOK WONG¹⁰, YUK-MAN LEUNG^8,*, YI-PING HUANG^8,*

Oncology Research, Vol.33, No.2, pp. 397-406, 2025, DOI:10.32604/or.2024.052743 - 16 January 2025

Abstract Objectives: Mitochondrial Ca²⁺ uniporter (MCU) provides a Ca²⁺ influx pathway from the cytosol into the mitochondrial matrix and a moderate mitochondrial Ca²⁺ rise stimulates ATP production and cell growth. MCU is highly expressed in various cancer cells including breast cancer cells, thereby increasing the capacity of mitochondrial Ca²⁺ uptake, ATP production, and cancer cell proliferation. The objective of this study was to examine MCU inhibition as an anti-cancer mechanism. Methods: The effects of MCU-i4, a newly developed MCU inhibitor, on cell viability, apoptosis, cytosolic Ca²⁺, mitochondrial Ca²⁺ and potential, glycolytic rate, generation of ATP, and reactive oxygen species,… More >

NASSER MULLA^1,*, YOUSEF KATIB², ASIM M. ALMUGHAMSI³, DUAA S. ALKHAYAT¹, MOHAMED MOSAAD^1,4, SAMIR T. ALFOTIH⁵, RAWAN ALAOFI⁶

Oncology Research, Vol.33, No.1, pp. 149-160, 2025, DOI:10.32604/or.2024.050903 - 20 December 2024

Abstract Background: Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients’ overall survival (OS). Methods: A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis. Results: The mean patient age of all… More >

A. M. Kadim^*, M. K. Abid

Chalcogenide Letters, Vol.21, No.4, pp. 327-333, 2024, DOI:10.15251/CL.2024.214.327

Abstract Zinc telluride (ZnTe) nanocrystals (NCs) have generated the interest of researchers as an electrode material in hybrid light emitting devices (HLEDs) due to its potentially high capacity. However, due to the restricted fundamental charging capacity of the electrode materials, the available energy of existing nanomaterial light emitting devices remains enough for a wide range of applications. In this research, ZnTe nanocrystals were synthesized using Nd: YAG laser at energy 600 mJ by 150 pulse number to form a battery device out of ITO/ZnTe/TPD/Ni. The spectra of the ZnTe NCs were assessed using ultraviolet-visible (UV-VIS) and More >

Stephen E. Strup

Canadian Journal of Urology, Vol.31, No.3, pp. 11897-11897, 2024

Abstract This article has no abstract. More >

Shridhar C. Ghagane^1,3, Shadab Rangrez³, R.B. Nerli^2,3, Madhukar L. Thakur^4,6, Leonard G. Gomella^5,6

Canadian Journal of Urology, Vol.31, No.3, pp. 11892-11896, 2024

Abstract Introduction: Prostate cancer is the second most common malignancy in men worldwide. Genomic VPAC receptors are expressed on malignant prostate cancer cells and can be targeted and imaged optically by a peptide labeled fluorophore. The objective of our study was to assess the feasibility of detecting cancer of the prostate using a voided urine sample.
Materials and methods: Patients ≥ 40 years old, with lower urinary tract symptoms and serum PSA > 4 ng/ mL formed the study group. The first 50 mL of voided urine sample was collected and processed. The cells that were shed in… More >

Zhanhua Wang^1,*, Hesheng Xia¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.012859

Abstract Selective laser sintering (SLS) is one of the mainstream 3D printing technologies. A major challenge for SLS technology is the lack of novel polymer powder materials with improved Z-direction strength. Herein, a series of polymer materials with covalent adaptable networks structure were utilized to solve the challenge of SLS. To verify this concept, novel kinds of cross-linked polyurethanes (TPU) or polydimethylsiloxane (PDMS) elastomers containing dynamic covalent bonds including halogenated bisphenol carbamate bonds [1], hindered pyrazole urea bonds [2] or Diels–Alder bonds [3] were synthesized. The obtained dynamic TPU or PDMS exhibited excellent mechanical strength and More >

Quanqing Tao^1,*, Qingping Ma¹, Xu Song¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011311

Abstract This paper explores the design and fabrication of ultralight, rib-strengthened mechanical metamaterials, specifically focusing on thin-walled lattice structure and rib-formed lattice structure in micro 3D printing. The lattice structures, based on triply periodic minimal surfaces (TPMS) and constant mean curvature surfaces (CMCS), provide large surface areas and continuous internal channels with lightweight and multifunctional structural applications. Algorithm designed in this paper incorporates a dynamics relaxation solver to generate pure TPMS and ribbed CMCS, enhancing the lattice design of metamaterials and the use of parametric modeling facilitates the creation of metamaterial lattice models. The paper delves… More >

Muhd Azimin bin Ab Ghani¹, Zhongwei Guan^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011074

Abstract Thermoplastic polyurethane (TPU) offers a superior impact and perforation resistance. This paper presents a study on manufacturing a range of hybrid laminated structures made of TPU, glass fibre reinforced plastic (GFRP), styrene-butadiene rubber (SBR) and metal mesh materials, and further on investigating the structural response of the TPU based composite sandwich laminated structures. These laminated structures were tested under quasi-static perforation and low velocity impact loading to determine their structural responses and energy absorption characteristics. It has been shown that three-layer and five-layer laminates with lay-ups of GFRP-TPU-GFRP or TPU-GFRP-TPU and GFRP-TPU-GFRP-TPU-GFRP or TPU-GFRP-TPU-GFRP-TPU subjected… More >

Huiting Zou^1,2, Zheng Zhang^3,*, Peng Chen⁴

International Journal of Mental Health Promotion, Vol.26, No.11, pp. 925-934, 2024, DOI:10.32604/ijmhp.2024.056444 - 28 November 2024

Abstract Background: The mental health challenges faced by police officers due to high-stress work environments necessitate effective interventions. Cognitive-behavioral therapy (CBT) has shown promise in addressing mental health issues, and this study aims to evaluate the efficacy of smartphone-based cognitive-behavioral therapy (SCBT) in improving mental health outcomes among police officers. This intervention could provide a reference for enhancing mental health literacy and resilience in this population. Methods: A randomized controlled trial (RCT) design was employed, involving 291 police officers who were randomly assigned to either the SCBT intervention group (n = 145) or the control group… More >

Weiru Wang¹, Yulong Cao^1,*, Yanxu Wang¹, Jiale You¹, Guangnan Zhang¹, Yu Xiao²

Energy Engineering, Vol.121, No.12, pp. 3801-3823, 2024, DOI:10.32604/ee.2024.055398 - 22 November 2024

Abstract To ensure frequency stability in power systems with high wind penetration, the doubly-fed induction generator (DFIG) is often used with the frequency fast response control (FFRC) to participate in frequency response. However, a certain output power suppression amount (OPSA) is generated during frequency support, resulting in the frequency modulation (FM) capability of DFIG not being fully utilised, and the system’s unbalanced power will be increased during speed recovery, resulting in a second frequency drop (SFD) in the system. Firstly, the frequency response characteristics of the power system with DFIG containing FFRC are analysed. Then, based… More >