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  • Open Access


    Semaphorin 7A promotes human vascular smooth muscle cell proliferation and migration through the β-catenin signaling pathway


    BIOCELL, Vol.47, No.4, pp. 849-858, 2023, DOI:10.32604/biocell.2023.026545

    Abstract Background: Vascular smooth muscle cells (VSMCs) undergo a conversion from a contractile phenotype to a proliferative synthetic phenotype, contributing to the pathogenesis of cardiovascular diseases. Semaphorin 7A (SEMA7A) is a glycosylphosphatidylinositol-anchored membrane protein that plays an important role in vascular homeostasis by regulating endothelial cell behaviors. However, the expression and role of SEMA7A in VSMCs remain unclear.Methods: In this study, we screened for VSMC-regulating genes in publicly available datasets and analyzed the expression of SEMA7A in human coronary artery smooth muscle cells (hCASMCs) treated with platelet-derived growth factor-BB (PDGF-BB). The effects of SEMA7A overexpression and knockdown… More >

  • Open Access


    Proteoglycans production by aortic vascular smooth muscle cells from hypertensive rats

    Norma Risler, Claudia Castro, Montserrat Cruzado, Susana González, Roberto Miatello

    BIOCELL, Vol.27, No.2, pp. 189-196, 2003, DOI:10.32604/biocell.2003.27.189

    Abstract Remodeling of large and small arteries contributes to the development and complications of hypertension. Artery structural changes in chronic sustained hypertension include vascular smooth muscle cells (VSMC) proliferation and extracellular matrix (ECM) modifications. Extracellular constituents such as proteoglycans (PGs), may modulate vascular stiffness and VSMC growth and differentiation. We examined the effect of growth factors on secreted and membrane-bound PGs synthesis by cultured aortic smooth muscle cells (SMC) from 12- to 14- week-old spontaneously hypertensive rats (SHR) and age-matched Wistar rats. After stimulation with platelet-derived growth factor (PDGF-BB), 10% fetal calf serum (FCS) or 0.1%… More >

  • Open Access


    Changes of inducible nitric oxide synthase in aortic cells during the development of hypertension: Effect of angiotensin II

    M. Cruzado, C. Castro, N. Risler, R. Miatello

    BIOCELL, Vol.26, No.1, pp. 61-67, 2002, DOI:10.32604/biocell.2002.26.061

    Abstract Nitric oxide (NO) generation by inducible nitric oxide synthase (iNOS) in the vascular smooth muscle cells (VSMC), may play a role in blood vessel tone regulation. Lipopolysaccharide (LPS) induced iNOS activity and subsequent nitrite production by cultured aortic VSMC, from SHR with an established chronic blood pressure elevation (adult SHR) or during the period preceding the development of hypertension (young SHR) and from age-matched normotensive Wistar (W) rats were compared. Angiotensin II (Ang II) effect was also evaluated. Both basal LPS-induced iNOS activity and nitrite accumulation were significantly lower in young SHR VSMC compared… More >

  • Open Access


    Oct-1 Mediates ACTH-Induced Proliferation of Vascular Smooth Muscle Cells

    Qian Xiao1, Xia Tang1, Yuanxiu Chen1, Han Bao1, Lizhi Gao1,2, Xiaobo Gong3,*, Ping Zhang1,4,*

    Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 199-210, 2019, DOI:10.32604/mcb.2019.07107

    Abstract Adrenocorticotrophic hormone (ACTH), a 39-amino acid peptide hormone, has been reported in the appreciation of the proliferation of vascular smooth muscle cells (VSMCs), however, the mechanism in molecular scale supporting the appreciation remains to be elucidated. In this study, we observed that the protein expression levels of ACTH at 24 h after exposure to 15% cyclic stretch were significantly higher than that after 5% cyclic stretch. When VSMCs were treated with 1000 nM ACTH directly, Oct-1 and lamin B1 expression were both up-regulated associating with each other, and the presence of Oct-1 was found shuttling… More >

  • Open Access


    Mechanical Properties of Stem Cells from Different Sources During Vascular Smooth Muscle Cell Differentiation

    Ruikai Chen1, Delphine Dean1,*

    Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 153-169, 2017, DOI:10.3970/mcb.2017.014.153

    Abstract Vascular smooth muscle cells (VSMCs) play an important role in regulating blood flow and pressure by contracting and relaxing in response to a variety of mechanical stimuli. A fully differentiated and functional VSMC should have both the ability to contract and relax in response to environmental stimuli. In addition, it should have the proper mechanical properties to sustain the mechanically active vascular environment. Stem cells can differentiate towards VSMC lineages and so could be used as a potential treatment for vascular repair. However, few studies have assessed the time it takes for stems cells to… More >

  • Open Access


    Regulation of Vascular Smooth Muscle Cells and Mesenchymal Stem Cells by Mechanical Strain

    Kyle Kurpinski1,2,3, Jennifer Park1,2,3, Rahul G. Thakar1,2,3, Song Li1,2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 21-34, 2006, DOI:10.3970/mcb.2006.003.021

    Abstract Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to More >

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