Ranran Yang^1,2,3,#, Dan Yuan^2,#, Chaohan Liang^4,#, Siying Zhu⁴, Jie Huang², Yingqi Zhang⁴, Weiling He⁵, Qinghai Li^1,*, Hong Zhang^2,*

Oncology Research, Vol.33, No.12, pp. 3945-3971, 2025, DOI:10.32604/or.2025.064463 - 27 November 2025

Abstract Background: Colorectal cancer (CRC) is a predominant contributor to global cancer-associated mortality worldwide. Oxaliplatin (OXP), a foundational chemotherapeutic agent for CRC, often exhibits limited efficacy due to the emergence of drug resistance. Although endothelin-1 (EDN1) has been implicated in tumor drug resistance, its role in oxaliplatin resistance in CRC remains poorly defined. This work aimed to define how EDN1 contributes to oxaliplatin resistance and to explore its potential as a therapeutic target. Methods: Public genomic datasets were analyzed to confirm EDN1 upregulation in colorectal cancer (CRC) and its association with poor prognosis. EDN1 expression was… More >

Muflih Alhazmi¹, Waqar Ul Hassan², Saba Shaheen³, Mohammed M. A. Almazah⁴, Azmat Ullah Khan Niazi^3,*, Nafisa A. Albasheir⁵, Ameni Gargouri⁶, Naveed Iqbal⁷

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1903-1940, 2025, DOI:10.32604/cmes.2025.072973 - 26 November 2025

Abstract This paper proposes a model-based control framework for vehicle platooning systems with second-order nonlinear dynamics operating over switching signed networks, time-varying delays, and deception attacks. The study includes two configurations: a leaderless structure using Finite-Time Non-Singular Terminal Bipartite Consensus (FNTBC) and Fixed-Time Bipartite Consensus (FXTBC), and a leader—follower structure ensuring structural balance and robustness against deceptive signals. In the leaderless model, a bipartite controller based on impulsive control theory, gauge transformation, and Markovian switching Lyapunov functions ensures mean-square stability and coordination under deception attacks and communication delays. The FNTBC achieves finite-time convergence depending on initial More >

Hong Wu, Yang Liu^*

BIOCELL, Vol.49, No.10, pp. 1985-2006, 2025, DOI:10.32604/biocell.2025.069527 - 22 October 2025

Abstract Background: Acute pancreatitis (AP) is a serious gastrointestinal disorder. Tetramethylpyrazine (TMP), a bioactive alkaloid extracted from Ligusticum chuanxiong, exhibits various pharmacological effects, but its protective mechanisms against AP remain unclear. This study aimed to investigate the protective effects and underlying mechanisms of TMP in AP. Methods: The study utilized Cerulein (CER) to model pancreatitis across experimental systems. Cellular responses were characterized through functional assays (CCK-8 viability, EdU proliferation, Transwell migration, flow cytometric apoptosis, Fluo-3/AM calcium imaging) and inflammatory profiling (ELISA for trypsin, CRP, TNF-α, IL-1β, IL-6). Autophagy was monitored via mRFP-GFP-LC3 flux and LysoTracker staining, with… More > Graphic Abstract

Mohammad Soleimani Amiri¹, Sahbi Boubaker^2,3,*, Rizauddin Ramli^4,*, Souad Kamel²

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3113-3133, 2025, DOI:10.32604/cmes.2025.069167 - 30 September 2025

Abstract Disability is defined as a condition that makes it difficult for a person to perform certain vital activities. In recent years, the integration of the concepts of intelligence in solving various problems for disabled persons has become more frequent. However, controlling an exoskeleton for rehabilitation presents challenges due to their non-linear characteristics and external disturbances caused by the structure itself or the patient wearing the exoskeleton. To remedy these problems, this paper presents a novel adaptive control strategy for upper-limb rehabilitation exoskeletons, addressing the challenges of nonlinear dynamics and external disturbances. The proposed controller integrated… More >

Mohammed Althubyani^1,*, Nidal E. Taha², Khdija O. Taha², Rasmiyah A. Alharb², Sayed Saber^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3491-3521, 2025, DOI:10.32604/cmes.2025.061640 - 30 June 2025

Abstract This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo (ABC) sense. Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives, the proposed model incorporates nonlocal memory effects, hereditary properties, and complex transmission dynamics through fractal-fractional calculus. The Atangana-Baleanu operator, with its non-singular Mittag-Leffler kernel, ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models. The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis, including local More >

Umar Shafique¹, Ali Raza^2,7,*, Dumitru Baleanu³, Khadija Nasir⁴, Muhammad Naveed⁵, Abu Bakar Siddique¹, Emad Fadhal^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 449-476, 2025, DOI:10.32604/cmes.2025.061635 - 11 April 2025

Abstract Streptococcus suis (S. suis) is a major disease impacting pig farming globally. It can also be transferred to humans by eating raw pork. A comprehensive study was recently carried out to determine the indices through multiple geographic regions in China. Methods: The well-posed theorems were employed to conduct a thorough analysis of the model’s feasible features, including positivity, boundedness equilibria, reproduction number, and parameter sensitivity. Stochastic Euler, Runge Kutta, and Euler Maruyama are some of the numerical techniques used to replicate the behavior of the streptococcus suis infection in the pig population. However, the dynamic… More >

BIAO WU^1,#, XIANLIN GUO^2,#, ZHISHI WU¹, LIANG CHEN^1,*, SUQING ZHANG^3,*

Oncology Research, Vol.33, No.4, pp. 975-988, 2025, DOI:10.32604/or.2025.058085 - 19 March 2025

Abstract Objectives: Although Yes-associated protein 1 (YAP1) is an important oncogene in hepatocellular carcinoma (HCC) progression, its nuclear localization prevents it from being considered a potential therapeutic target. Recently, studies have reported that coatomer protein complex subunit beta 2 (COPB2) also plays a critical role in HCC development; however its mechanism of action is unclear. This study aimed to investigate the role of COPB2 and YAP1 in the progression of HCC and to elucidate the underlying mechanisms. Methods: COPB2 and YAP1 expression in HCC tissues were first analyzed by database searches and immunohistochemistry. Nomogram and artificial… More >

Mehmet Karahan^*

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 777-798, 2025, DOI:10.32604/cmc.2024.059123 - 03 January 2025

Abstract Advances in software and hardware technologies have facilitated the production of quadrotor unmanned aerial vehicles (UAVs). Nowadays, people actively use quadrotor UAVs in essential missions such as search and rescue, counter-terrorism, firefighting, surveillance, and cargo transportation. While performing these tasks, quadrotors must operate in noisy environments. Therefore, a robust controller design that can control the altitude and attitude of the quadrotor in noisy environments is of great importance. Many researchers have focused only on white Gaussian noise in their studies, whereas researchers need to consider the effects of all colored noises during the operation of… More >

Miao Huang¹, Maedeh Lotfi¹, Heyang Wang⁴, Hayley Sussman⁵, Kevin Connell¹, Quang Vo¹, Malisa Sarntinoranont¹, Hitomi Yamaguchi¹, Juan Guan², Xin Tang^1,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011130

Abstract Mechanotransduction, i.e., living cells sense and transduce mechanical forces into intracellular biochemical signaling and gene expression, is ubiquitous across diverse organisms. Increasing evidence suggests that mechanotransduction significantly influences cell functions and its mis-regulation is at the heart of various pathologies. A quantitative characterization of the relationship between mechanical forces and resulted mechanotransduction is pivotal in understanding the rules of life and innovating new therapeutic strategies [1-3]. However, while such relationship on the cell surface membrane and cytoskeleton have been well studied, little is known about whether/how mechanical forces applied on the cell interior nucleus (“headquarter… More >

Haowen Liang¹, Jiaming Bai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012563

Abstract Defects are pivotal in influencing the mechanical performance of the hydroxyapatite (HAp) porous structure. In vat photopolymerization (VP) fabrication, directly peeling HAp/polymer green structure from the platform is an efficient approach but often introduces defects, compromising the mechanical performance of sintered HAp scaffolds. The peeling process is a physical phenomenon where the photocured HAp/polymer green structure exhibits resistance against applied peeling forces, which is influenced by its modulus and toughness. In this study, the peeling behavior of cubic-pore HAp (CP-HAp) green structures with varying levels of modulus and toughness was investigated in detail. The characterization… More >