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Search Results (16)
  • Open Access

    ARTICLE

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

    CHONG SHEN, JIAJUN YAN*, YU REN, ZHIRONG ZHU, XIAOLONG ZHANG, SHUIXIANG TAO

    BIOCELL, Vol.48, No.1, pp. 97-109, 2024, DOI:10.32604/biocell.2023.045303

    Abstract Introduction: Bladder cancer (BC) has a high incidence and mortality rate worldwide. Suppressor anaphase-promoting complex domain containing 2 (SAPCDC2) is over-expressed in a variety of tumors. Objectives: This study investigated the effects of SAPCD2 knockdown on BC cells. Methods: T24 and UMUC3 cell models and the xenografted BC tumor model with SAPCD2 knockdown were established to observe the malignant phenotype of BC cells by cell counting kit-8 assay, colony formation test, wound healing, and Transwell assay, mRNA and proteins expressions were measured with quantitative real-time polymerase chain reaction, western blotting, and tissue immunohistochemistry. Lithium chloride agonist on the Wnt/β-catenin pathway… More > Graphic Abstract

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

  • Open Access

    ARTICLE

    Optimized Decision Tree and Black Box Learners for Revealing Genetic Causes of Bladder Cancer

    Sait Can Yucebas*

    Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 49-71, 2023, DOI:10.32604/iasc.2023.036871

    Abstract The number of studies in the literature that diagnose cancer with machine learning using genome data is quite limited. These studies focus on the prediction performance, and the extraction of genomic factors that cause disease is often overlooked. However, finding underlying genetic causes is very important in terms of early diagnosis, development of diagnostic kits, preventive medicine, etc. The motivation of our study was to diagnose bladder cancer (BCa) based on genetic data and to reveal underlying genetic factors by using machine-learning models. In addition, conducting hyper-parameter optimization to get the best performance from different models, which is overlooked in… More >

  • Open Access

    ARTICLE

    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study

    GUSTAVO MARTÍN VILLOLDO1, MARÍA TERESA POMBO2, MARIANA ARIS3, JOAQUÍN CHEMI1, PABLO MANDÓ3, SUPRIYA NAGARAJU4, JUAN CAMEAN1, ADRIÁN BURIONI1, DEBORAH EGEA1, MORA AMAT5, JOSÉ LEÓN MELLADO3, JOSÉ MORDOH3, ALBERTO VILLARONGA1, MARÍA MARCELA BARRIO3,*

    Oncology Research, Vol.31, No.2, pp. 207-220, 2023, DOI:10.32604/or.2023.028163

    Abstract Intravesical Bacillus Calmette Guerin (BCG) is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer (NMIBC). However, the response rate is ~60%, and 50% of non-responders will progress to muscle-invasive disease. BCG induces massive local infiltration of inflammatory cells (Th1) and ultimately cytotoxic tumor elimination. We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte (TIL) polarization in the tumor microenvironment (TME) in pre-treatment biopsies. Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG (n = 32) were evaluated retrospectively by immunohistochemistry. TME polarization was assessed by quantifying the T-Bet+ (Th1) and GATA-3+… More > Graphic Abstract

    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study

  • Open Access

    REVIEW

    Ferroptosis’s Role in Genitourinary System Cancer

    Chaoying Liu1,#, Xinfeng Yang2,#, Ye Wang2,#, Keyu Wu2, Siqiang Li2, Gailing Wang2, Yun Li2, Chuanfeng Li2, Mingcheng Wang2, Enzhong Li2,*

    Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705

    Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

  • Open Access

    ARTICLE

    Performance Measurement of Energy Efficient and Highly Scalable Hybrid Adder

    B. Annapoorani*, P. Marikkannu

    Computer Systems Science and Engineering, Vol.45, No.3, pp. 2659-2672, 2023, DOI:10.32604/csse.2023.025075

    Abstract The adders are the vital arithmetic operation for any arithmetic operations like multiplication, subtraction, and division. Binary number additions are performed by the digital circuit known as the adder. In VLSI (Very Large Scale Integration), the full adder is a basic component as it plays a major role in designing the integrated circuits applications. To minimize the power, various adder designs are implemented and each implemented designs undergo defined drawbacks. The designed adder requires high power when the driving capability is perfect and requires low power when the delay occurred is more. To overcome such issues and to obtain better… More >

  • Open Access

    ARTICLE

    Two-Stage Low-Carbon Economic Dispatch of Integrated Demand Response-Enabled Integrated Energy System with Ladder-Type Carbon Trading

    Song Zhang1, Wensheng Li2, Zhao Li2, Xiaolei Zhang1, Zhipeng Lu1, Xiaoning Ge3,*

    Energy Engineering, Vol.120, No.1, pp. 181-199, 2023, DOI:10.32604/ee.2022.022228

    Abstract Driven by the goal of “carbon neutrality” and “emission peak”, effectively controlling system carbon emissions has become significantly important to governments around the world. To this end, a novel two-stage low-carbon economic scheduling framework that considers the coordinated optimization of ladder-type carbon trading and integrated demand response (IDR) is proposed in this paper for the integrated energy system (IES), where the first stage determines the energy consumption plan of users by leveraging the price-based electrical-heat IDR. In contrast, the second stage minimizes the system total cost to optimize the outputs of generations with consideration of the uncertainty of renewables. In… More >

  • Open Access

    ARTICLE

    A Secure Hardware Implementation for Elliptic Curve Digital Signature Algorithm

    Mouna Bedoui1,*, Belgacem Bouallegue1,2, Abdelmoty M. Ahmed2, Belgacem Hamdi1,3, Mohsen Machhout1, Mahmoud1, M. Khattab2

    Computer Systems Science and Engineering, Vol.44, No.3, pp. 2177-2193, 2023, DOI:10.32604/csse.2023.026516

    Abstract Since the end of the 1990s, cryptosystems implemented on smart cards have had to deal with two main categories of attacks: side-channel attacks and fault injection attacks. Countermeasures have been developed and validated against these two types of attacks, taking into account a well-defined attacker model. This work focuses on small vulnerabilities and countermeasures related to the Elliptic Curve Digital Signature Algorithm (ECDSA) algorithm. The work done in this paper focuses on protecting the ECDSA algorithm against fault-injection attacks. More precisely, we are interested in the countermeasures of scalar multiplication in the body of the elliptic curves to protect against… More >

  • Open Access

    ARTICLE

    Design of Multi-Valued Logic Circuit Using Carbon Nano Tube Field Transistors

    S. V. Ratankumar1,2, L. Koteswara Rao1,*, M. Kiran Kumar3

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5283-5298, 2022, DOI:10.32604/cmc.2022.027975

    Abstract The design of a three-input logic circuit using carbon nanotube field effect transistors (CNTFETs) is presented. Ternary logic must be an exact replacement for dual logic since it performs straightforwardly in digital devices, which is why this design is so popular, and it also reduces chip area, both of which are examples of circuit overheads. The proposed module we have investigated is a triple-logic-based one, based on advanced technology CNTFETs and an emphasis on minimizing delay times at various values, as well as comparisons of the design working with various load capacitances. Comparing the proposed design with the existing design,… More >

  • Open Access

    ARTICLE

    Analysis of Efficient 32 Bit Adder Using Tree Grafting Technique

    R. Gowrishankar1,*, N. Sathish Kumar2

    Intelligent Automation & Soft Computing, Vol.35, No.1, pp. 1197-1209, 2023, DOI:10.32604/iasc.2023.025422

    Abstract Adder with high efficiency and accuracy is the major requirement for electronic circuit design. Here the optical logic gate based adder circuit is designed for better performance analysis of optical input signals varied with the wavelength. Efficiency of the adder can be improved by increasing the speed of operation, reducing the complexity and power consumption. To maintain the high efficiency with accuracy, a new combination of adder has been proposed and tested in this work. A new adder by combining the logics of Brent Kung, Sklansky and Kogge Stone adders by Tree Grafting Technique (BSKTGT) has been tested along with… More >

  • Open Access

    ARTICLE

    Energy Conservation of Adiabatic ECRL-Based Kogge-Stone Adder Circuits for FFT Applications

    P. Dhilipkumar1,*, G. Mohanbabu2

    Intelligent Automation & Soft Computing, Vol.32, No.3, pp. 1445-1458, 2022, DOI:10.32604/iasc.2022.021663

    Abstract Low Power circuits play a significant role in designing large-scale devices with high energy and power consumption. Adiabatic circuits are one such energy-saving circuits that utilize reversible power. Several methodologies used previously infer the use of CMOS circuits for reducing power dissipation in logic circuits. However, CMOS devices hardly manage in maintaining their performance when it comes to fast switching networks. Adiabatic technology is employed to overcome these difficulties, which can further scale down the dissipation of power by charging and discharging. An Efficient Charge Recovery Logic (ECRL) based adiabatic technology is used here to evaluate arithmetic operations in circuits… More >

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