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  • Open Access

    RETRACTION

    Retraction: miR-203 suppresses bladder cancer cell growth and targets twist1

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.10, pp. 1693-1694, 2024, DOI:10.32604/or.2024.056909 - 18 September 2024

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: MicroRNA-940 Targets INPP4A or GSK3β and Activates the Wntβ-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.9, pp. 1537-1537, 2024, DOI:10.32604/or.2024.056125 - 23 August 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Ladder Time Stepwise Inertia Coordinated Control Method of Multiple Wind Farms to Suppress System Frequency Secondary Drop

    He Li1, Xianchao Liu2,*, Jidong Li1, Yuchen Qiu2

    Energy Engineering, Vol.121, No.8, pp. 2293-2311, 2024, DOI:10.32604/ee.2024.048752 - 19 July 2024

    Abstract When employing stepwise inertial control (SIC), wind power generation can offer significant frequency support to the power system, concurrently mitigating energy shortages and suppressing secondary frequency drop. Nonetheless, further investigation is imperative for implementing stepped inertia control due to variations in frequency regulation capabilities and operational safety among diverse wind farm groups. Consequently, this paper advocates a multi-wind farm ladder timing SIC method designed to alleviate secondary drops in system frequency. Initially, the paper introduces the fundamental principles of stepped inertia control for a doubly-fed induction generator (DFIG) and deduces the relationship between support energy,… More >

  • Open Access

    ARTICLE

    New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B

    HYUNHO KIM1, UIJU CHO2, SOOK HEE HONG3, HYUNG SOON PARK1, IN-HO KIM3, HO JUNG AN1, BYOUNG YONG SHIM1, JIN HYOUNG KANG3,*

    Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919 - 23 May 2024

    Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442 - 20 March 2024

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    ARTICLE

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

    CHONG SHEN, JIAJUN YAN*, YU REN, ZHIRONG ZHU, XIAOLONG ZHANG, SHUIXIANG TAO

    BIOCELL, Vol.48, No.1, pp. 97-109, 2024, DOI:10.32604/biocell.2023.045303 - 30 January 2024

    Abstract Introduction: Bladder cancer (BC) has a high incidence and mortality rate worldwide. Suppressor anaphase-promoting complex domain containing 2 (SAPCDC2) is over-expressed in a variety of tumors. Objectives: This study investigated the effects of SAPCD2 knockdown on BC cells. Methods: T24 and UMUC3 cell models and the xenografted BC tumor model with SAPCD2 knockdown were established to observe the malignant phenotype of BC cells by cell counting kit-8 assay, colony formation test, wound healing, and Transwell assay, mRNA and proteins expressions were measured with quantitative real-time polymerase chain reaction, western blotting, and tissue immunohistochemistry. Lithium chloride agonist… More > Graphic Abstract

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

  • Open Access

    ARTICLE

    Optimized Decision Tree and Black Box Learners for Revealing Genetic Causes of Bladder Cancer

    Sait Can Yucebas*

    Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 49-71, 2023, DOI:10.32604/iasc.2023.036871 - 29 April 2023

    Abstract The number of studies in the literature that diagnose cancer with machine learning using genome data is quite limited. These studies focus on the prediction performance, and the extraction of genomic factors that cause disease is often overlooked. However, finding underlying genetic causes is very important in terms of early diagnosis, development of diagnostic kits, preventive medicine, etc. The motivation of our study was to diagnose bladder cancer (BCa) based on genetic data and to reveal underlying genetic factors by using machine-learning models. In addition, conducting hyper-parameter optimization to get the best performance from different… More >

  • Open Access

    ARTICLE

    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study

    GUSTAVO MARTÍN VILLOLDO1, MARÍA TERESA POMBO2, MARIANA ARIS3, JOAQUÍN CHEMI1, PABLO MANDÓ3, SUPRIYA NAGARAJU4, JUAN CAMEAN1, ADRIÁN BURIONI1, DEBORAH EGEA1, MORA AMAT5, JOSÉ LEÓN MELLADO3, JOSÉ MORDOH3, ALBERTO VILLARONGA1, MARÍA MARCELA BARRIO3,*

    Oncology Research, Vol.31, No.2, pp. 207-220, 2023, DOI:10.32604/or.2023.028163 - 10 April 2023

    Abstract Intravesical Bacillus Calmette Guerin (BCG) is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer (NMIBC). However, the response rate is ~60%, and 50% of non-responders will progress to muscle-invasive disease. BCG induces massive local infiltration of inflammatory cells (Th1) and ultimately cytotoxic tumor elimination. We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte (TIL) polarization in the tumor microenvironment (TME) in pre-treatment biopsies. Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG (n = 32) were evaluated retrospectively by immunohistochemistry. TME polarization was assessed by quantifying… More > Graphic Abstract

    A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma: A retrospective study

  • Open Access

    ARTICLE

    Performance Measurement of Energy Efficient and Highly Scalable Hybrid Adder

    B. Annapoorani*, P. Marikkannu

    Computer Systems Science and Engineering, Vol.45, No.3, pp. 2659-2672, 2023, DOI:10.32604/csse.2023.025075 - 21 December 2022

    Abstract The adders are the vital arithmetic operation for any arithmetic operations like multiplication, subtraction, and division. Binary number additions are performed by the digital circuit known as the adder. In VLSI (Very Large Scale Integration), the full adder is a basic component as it plays a major role in designing the integrated circuits applications. To minimize the power, various adder designs are implemented and each implemented designs undergo defined drawbacks. The designed adder requires high power when the driving capability is perfect and requires low power when the delay occurred is more. To overcome such… More >

  • Open Access

    ARTICLE

    Two-Stage Low-Carbon Economic Dispatch of Integrated Demand Response-Enabled Integrated Energy System with Ladder-Type Carbon Trading

    Song Zhang1, Wensheng Li2, Zhao Li2, Xiaolei Zhang1, Zhipeng Lu1, Xiaoning Ge3,*

    Energy Engineering, Vol.120, No.1, pp. 181-199, 2023, DOI:10.32604/ee.2022.022228 - 27 October 2022

    Abstract Driven by the goal of “carbon neutrality” and “emission peak”, effectively controlling system carbon emissions has become significantly important to governments around the world. To this end, a novel two-stage low-carbon economic scheduling framework that considers the coordinated optimization of ladder-type carbon trading and integrated demand response (IDR) is proposed in this paper for the integrated energy system (IES), where the first stage determines the energy consumption plan of users by leveraging the price-based electrical-heat IDR. In contrast, the second stage minimizes the system total cost to optimize the outputs of generations with consideration of More >

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