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  • Open Access

    RESIDENT’S CORNER

    Rapid onset severe hyperkalemia during robotic radical cystectomy: a case report

    Matthew Buell, Brian Hu

    Canadian Journal of Urology, Vol.31, No.5, pp. 12026-12029, 2024

    Abstract Radical cystectomy is a preferred treatment for muscle invasive bladder cancer. Despite known complications, rapid onset, severe hyperkalemia necessitating abortion of surgery has not been reported. In this case report, a patient with end stage renal disease (ESRD) undergoing attempted cystectomy developed severe intraoperative hyperkalemia and acidosis that led to abortion of surgery and transfer to the medical intensive care unit for emergent hemodialysis. The multifactorial etiology was related to respiratory acidosis, ESRD, patient positioning, clipping of ureters, and body habitus, as well as an idiopathic element. Knowledge of hyperkalemia etiologies can assist in diagnosis More >

  • Open Access

    ARTICLE

    Prehabilitation in patients undergoing bladder cancer surgery – A systematic review and meta-analysis

    Daniel Steffens1,2,3, Cherry Koh1,2,3,4, Nicholas Hirst1,2, Ruby Cole1,2, Michael J. Solomon1,2,3,4, Lisa Nguyen-Lal5

    Canadian Journal of Urology, Vol.31, No.5, pp. 12004-12012, 2024

    Abstract Introduction: The evidence on the effectiveness of prehabilitation in patients undergoing bladder cancer surgery remains lacking. Thus, the aim of this study is to determine the effectiveness of prehabilitation on reducing postoperative morbidity and length of hospital stay in patients undergoing bladder cancer surgery.
    Materials and methods: This systematic review included randomized controlled trials investigating the effect of prehabilitation on postoperative outcomes in patients undergoing bladder cancer surgery. A comprehensive search was conducted, with two reviewers independently screening articles and extracting data. The Cochrane Collaboration’s tool was used to assess risk of bias, and GRADE to rate… More >

  • Open Access

    REVIEW

    Illuminating the use of photodynamic therapy in urologic oncology

    Gabrielle R. Yankelevich1, Kale Moreland2, Makayla M. Swancutt2, Robert L. Grubb1

    Canadian Journal of Urology, Vol.31, No.6, pp. 12035-12044, 2024

    Abstract Introduction: We report the first scoping review of the clinical urologic literature for photodynamic therapy (PDT) among multiple urologic malignancies.
    Materials and methods: A scoping review using Medline and Embase was performed for treatment of urologic malignancies with PDT.
    Results: There were 84 papers included with the majority involving bladder and prostate cancer. Upper tract urothelial cancer (UTUC) only comprised three publications and there was no clinical data for renal or testicular cancer. Utilizing PDT in prostate cancer led to a negative biopsy rate of 30%-100%. Bladder cancer treatment with PDT had a 3-month complete response rate of More >

  • Open Access

    RETRACTION

    Retraction: long noncoding RNA ATB promotes proliferation, migration, and invasion in bladder cancer by suppressing microRNA-126

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.11, pp. 1819-1819, 2024, DOI:10.32604/or.2024.056893 - 16 October 2024

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: miR-203 suppresses bladder cancer cell growth and targets twist1

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.10, pp. 1693-1694, 2024, DOI:10.32604/or.2024.056909 - 18 September 2024

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: MicroRNA-940 Targets INPP4A or GSK3β and Activates the Wntβ-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.9, pp. 1537-1537, 2024, DOI:10.32604/or.2024.056125 - 23 August 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Ladder Time Stepwise Inertia Coordinated Control Method of Multiple Wind Farms to Suppress System Frequency Secondary Drop

    He Li1, Xianchao Liu2,*, Jidong Li1, Yuchen Qiu2

    Energy Engineering, Vol.121, No.8, pp. 2293-2311, 2024, DOI:10.32604/ee.2024.048752 - 19 July 2024

    Abstract When employing stepwise inertial control (SIC), wind power generation can offer significant frequency support to the power system, concurrently mitigating energy shortages and suppressing secondary frequency drop. Nonetheless, further investigation is imperative for implementing stepped inertia control due to variations in frequency regulation capabilities and operational safety among diverse wind farm groups. Consequently, this paper advocates a multi-wind farm ladder timing SIC method designed to alleviate secondary drops in system frequency. Initially, the paper introduces the fundamental principles of stepped inertia control for a doubly-fed induction generator (DFIG) and deduces the relationship between support energy,… More >

  • Open Access

    ARTICLE

    New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B

    HYUNHO KIM1, UIJU CHO2, SOOK HEE HONG3, HYUNG SOON PARK1, IN-HO KIM3, HO JUNG AN1, BYOUNG YONG SHIM1, JIN HYOUNG KANG3,*

    Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919 - 23 May 2024

    Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442 - 20 March 2024

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    ARTICLE

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

    CHONG SHEN, JIAJUN YAN*, YU REN, ZHIRONG ZHU, XIAOLONG ZHANG, SHUIXIANG TAO

    BIOCELL, Vol.48, No.1, pp. 97-109, 2024, DOI:10.32604/biocell.2023.045303 - 30 January 2024

    Abstract Introduction: Bladder cancer (BC) has a high incidence and mortality rate worldwide. Suppressor anaphase-promoting complex domain containing 2 (SAPCDC2) is over-expressed in a variety of tumors. Objectives: This study investigated the effects of SAPCD2 knockdown on BC cells. Methods: T24 and UMUC3 cell models and the xenografted BC tumor model with SAPCD2 knockdown were established to observe the malignant phenotype of BC cells by cell counting kit-8 assay, colony formation test, wound healing, and Transwell assay, mRNA and proteins expressions were measured with quantitative real-time polymerase chain reaction, western blotting, and tissue immunohistochemistry. Lithium chloride agonist… More > Graphic Abstract

    Inhibition of proliferation, migration, and invasiveness of bladder cancer cells through SAPCD2 knockdown

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