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  • Open Access

    ARTICLE

    Analysis of Efficient 32 Bit Adder Using Tree Grafting Technique

    R. Gowrishankar1,*, N. Sathish Kumar2

    Intelligent Automation & Soft Computing, Vol.35, No.1, pp. 1197-1209, 2023, DOI:10.32604/iasc.2023.025422

    Abstract Adder with high efficiency and accuracy is the major requirement for electronic circuit design. Here the optical logic gate based adder circuit is designed for better performance analysis of optical input signals varied with the wavelength. Efficiency of the adder can be improved by increasing the speed of operation, reducing the complexity and power consumption. To maintain the high efficiency with accuracy, a new combination of adder has been proposed and tested in this work. A new adder by combining the logics of Brent Kung, Sklansky and Kogge Stone adders by Tree Grafting Technique (BSKTGT) has been tested along… More >

  • Open Access

    ARTICLE

    Energy Conservation of Adiabatic ECRL-Based Kogge-Stone Adder Circuits for FFT Applications

    P. Dhilipkumar1,*, G. Mohanbabu2

    Intelligent Automation & Soft Computing, Vol.32, No.3, pp. 1445-1458, 2022, DOI:10.32604/iasc.2022.021663

    Abstract Low Power circuits play a significant role in designing large-scale devices with high energy and power consumption. Adiabatic circuits are one such energy-saving circuits that utilize reversible power. Several methodologies used previously infer the use of CMOS circuits for reducing power dissipation in logic circuits. However, CMOS devices hardly manage in maintaining their performance when it comes to fast switching networks. Adiabatic technology is employed to overcome these difficulties, which can further scale down the dissipation of power by charging and discharging. An Efficient Charge Recovery Logic (ECRL) based adiabatic technology is used here to… More >

  • Open Access

    ARTICLE

    Efficient Energy Optimized Faithful Adder with Parallel Carry Generation

    K. N. Vijeyakumar1, S. Maragatharaj2,*

    CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2543-2561, 2022, DOI:10.32604/cmc.2022.019789

    Abstract Approximate computing has received significant attention in the design of portable CMOS hardware for error-tolerant applications. This work proposes an approximate adder that to optimize area delay and achieve energy efficiency using Parallel Carry (PC) generation logic. For ‘n’ bits in input, the proposed algorithm use approximate addition for least n/2 significant bits and exact addition for most n/2 significant bits. A simple OR logic with no carry propagation is used to implement the approximate part. In the exact part, addition is performed using 4-bit adder blocks that implement PC at block level to reduce node capacitance… More >

  • Open Access

    ARTICLE

    GM-CSF-Loaded Nanoparticles for Photothermal-Assisted Immunotherapy against Orthotopic Bladder Cancer

    Weifeng Ren1,2,#, Xiaomeng Cai2,3,#, Jun Chen2,3,#, Lifo Ruan2,3, Huiru Lu2, Jiayu Zhang2,3, Yi Hu2,3,*, Jimin Gao1,*

    Oncologie, Vol.23, No.3, pp. 359-371, 2021, DOI:10.32604/Oncologie.2021.018605

    Abstract This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanoparticles facilitated their immobilization on biotinylated mouse orthotopic bladder cancer surface, resulting in slow release of antitumor immune adjuvant. Locally released GM-CSF efficiently recruited dendritic cells to bladder tumor sites, thereby promoting immune responses in mice. Thus, the activated immune response in mice provided enhanced antitumor effects. Meanwhile, the thermal effect from the nanoparticles upon light irradiation induced a significant increase in dendritic cells and T cells compared with other More >

  • Open Access

    ARTICLE

    Mir-612 Inhibits Proliferation and Invasion of Urothelial Carcinoma of Bladder Cells through Activating Hippo Pathway via Targeting PMEPA1

    Peng Wang, Haiyang Zhang, Zilian Cui, Xunbo Jin*, Dong Zhang*

    Oncologie, Vol.23, No.2, pp. 259-268, 2021, DOI:10.32604/Oncologie.2021.015503

    Abstract Urothelial carcinoma of bladder (UCB) is a common urological malignancy in the world, but its progression mechanism remains unclear. MiR-612 was found as an anti-tumor factor in multiple types of cancer, while few studies have revealed its functions in UCB cells. Based on this, UCB cells such as HTB-9 and HTB-4, and normal urothelial of bladder cells such as SV-Huc1, were used as subjects in this study. Western blot, qRTPCR, CCK-8 assay and transwell assay were used to assess functions of miR-612 in UCB cells. The database, miRWalk, was used to search for potential targets… More >

  • Open Access

    ARTICLE

    Extraction Hydrolysates from Larimichthys Polyactis Swim Bladder Using Enzymatic Hydrolysis

    Ling Pan1 , Yubo Tao2,*, Peng Li1,2,*

    Journal of Renewable Materials, Vol.9, No.6, pp. 1099-1109, 2021, DOI:10.32604/jrm.2021.014683

    Abstract As a kind of biopolymer, hydrolysates of fish swim bladder, safer than those of land mammals, are widely used in food, cosmetics as well as pharmaceutical and biomedical fields for their biocompatibility, biodegradability, and weak antigenicity. To enhance hydrolysate production, in this paper, the papain and alcalase hydrolysis processes of larimichthys polyactis swim bladder were optimized with orthogonal experiments. With 89.5% hydrolysate yield, the optimal processing conditions for alcalase were solid-liquid ratio of 1:30, enzyme concentration of 0.7%, and extraction time of 6 h. As for papain, under the optimal processing conditions: solid-liquid ratio of… More >

  • Open Access

    ARTICLE

    A Novel Design of Octal-Valued Logic Full Adder Using Light Color State Model

    Ahmed Talal, Osama Abu-Elnasr*, Samir Elmougy

    CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 3487-3503, 2021, DOI:10.32604/cmc.2021.015759

    Abstract Due to the demand of high computational speed for processing big data that requires complex data manipulations in a timely manner, the need for extending classical logic to construct new multi-valued optical models becomes a challenging and promising research area. This paper establishes a novel octal-valued logic design model with new optical gates construction based on the hypothesis of Light Color State Model to provide an efficient solution to the limitations of computational processing inherent in the electronics computing. We provide new mathematical definitions for both of the binary OR function and the PLUS operation More >

  • Open Access

    ARTICLE

    Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells

    QINGXIN LIU , XIANGGUI CHEN, GUOLIN YANG1 , XUEWEN MIN3 , AND MAOXIAN DENG1,*

    BIOCELL, Vol.35, No.3, pp. 71-80, 2011, DOI:10.32604/biocell.2011.35.071

    Abstract Apigenin, a nonmutagenic flavonoid, has been shown to possess free radical scavenging activities, anticarcinogenic properties, antioxidant and anti-inflammatory effects. Recently, apigenin was reported to cause gastric relaxation in murine. To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). Results showed that overexpression of active human MEKK1 by adenoviruses infection induced migration of human bladder smooth muscle (hBSM) cells and phosphorylation of MAPKs, ERK, JNK and More >

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