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  • Open Access

    ARTICLE

    Optimal Concentration of the Bubble Drainage Agent in Foam Drainage Gas Recovery Applications

    Shaopeng Liu1, Guowei Wang2,3,*, Pengfei Liu1, Dong Ye1, Jian Song1, Xing Liu1, Yang Cheng2,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3045-3058, 2023, DOI:10.32604/fdmp.2023.029810 - 27 October 2023

    Abstract Foam drainage is the flow of liquid through the interstitial spaces between bubbles driven by capillarity and gravity and resisted by viscous damping. The so-called foam drainage gas recovery technology is a technique traditionally used to mitigate the serious bottom-hole liquid loading in the middle and late stages of gas well production. In this context, determining the optimal concentration of the bubble drainage agent is generally crucial for the proper application of this method. In this study, a combination of indoor experiments and theoretical analysis have been used to determine the pressure drop related to… More >

  • Open Access

    ARTICLE

    Characterization of Endophytic Microorganisms of Rice (Oryza sativa L.) Potentials for Blast Disease Biocontrol and Plant Growth Promoting Agents

    Shugufta Parveen1, Fayaz A. Mohiddin2,*, M. Ashraf Bhat3, Zahoor Ahmed Baba4, Fehim Jeelani5, M. Anwar Bhat6, Sajad Un Nabi7, Burhan Hamid2, Saba Bandey8, Farhanaz Rasool9, Zakir Amin1, Ibrahim Al-Ashkar10,*, Muhammad Adnan11, Ayman El Sabagh12

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3021-3041, 2023, DOI:10.32604/phyton.2023.030921 - 24 October 2023

    Abstract One hundred twenty-five endophytic microorganisms were isolated from the roots, stems, and leaves of four prominent rice cultivars growing in temperate regions. Their potential to combat rice blast disease and promote plant growth was investigated. The dual culture tests highlighted the strong antagonistic activity of five fungal (ranging from 89%–70%) and five bacterial (72%–61%) endophytes. Subsequent examination focused on volatile compounds produced by selected isolates to counter the blast pathogen. Among these, the highest chitinase (13.76 µg mL−1) and siderophore (56.64%), was exhibited by Aspergillus flavus, and the highest HCN production was shown by Stenotrophomonas maltophilia (36.15 µM… More >

  • Open Access

    ARTICLE

    Multi-Agent Deep Reinforcement Learning for Efficient Computation Offloading in Mobile Edge Computing

    Tianzhe Jiao, Xiaoyue Feng, Chaopeng Guo, Dongqi Wang, Jie Song*

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3585-3603, 2023, DOI:10.32604/cmc.2023.040068 - 08 October 2023

    Abstract Mobile-edge computing (MEC) is a promising technology for the fifth-generation (5G) and sixth-generation (6G) architectures, which provides resourceful computing capabilities for Internet of Things (IoT) devices, such as virtual reality, mobile devices, and smart cities. In general, these IoT applications always bring higher energy consumption than traditional applications, which are usually energy-constrained. To provide persistent energy, many references have studied the offloading problem to save energy consumption. However, the dynamic environment dramatically increases the optimization difficulty of the offloading decision. In this paper, we aim to minimize the energy consumption of the entire MEC system… More >

  • Open Access

    ARTICLE

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

    YOHKO YAMAZAKI1,*, MANABU KAWADA2, ISAO MOMOSE1

    Oncology Research, Vol.31, No.6, pp. 845-853, 2023, DOI:10.32604/or.2023.030266 - 15 September 2023

    Abstract The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new AR inhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as a screening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that the fermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cells without cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline (DNT) being identified as a novel inhibitor of AR function. More > Graphic Abstract

    Deoxynortryptoquivaline: A unique antiprostate cancer agent

  • Open Access

    ARTICLE

    Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

    MAKOTO KAWATANI1,2,*, HARUMI AONO2, SAYOKO HIRANUMA3, TAKESHI SHIMIZU3, MAKOTO MUROI1,2, TOSHIHIKO NOGAWA4, TOMOKAZU OHISHI5, SHUN-ICHI OHBA5, MANABU KAWADA5, KANAMI YAMAZAKI6, SHINGO DAN6, NAOSHI DOHMAE1, HIROYUKI OSADA2,7,*

    Oncology Research, Vol.31, No.6, pp. 833-844, 2023, DOI:10.32604/or.2023.030241 - 15 September 2023

    Abstract Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening revealed that NPD723, which is reduced to H-006 in cells, strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells. H-006 also suppressed the growth of various cancer cells. Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors. H-006 potently inhibited human DHODH activity in vitro, whereas More >

  • Open Access

    REVIEW

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, Mpro, and PLpro: A review

    MOHAMAD ZULKEFLEE SABRI1, JOANNA BOJARSKA2, FAI-CHU WONG3,4, TSUN-THAI CHAI3,4,*

    BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272 - 28 August 2023

    Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (Mpro), and papain-like protease (PLpro).… More > Graphic Abstract

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, M<sup>pro</sup>, and PL<sup>pro</sup>: A review

  • Open Access

    ARTICLE

    AI Safety Approach for Minimizing Collisions in Autonomous Navigation

    Abdulghani M. Abdulghani, Mokhles M. Abdulghani, Wilbur L. Walters, Khalid H. Abed*

    Journal on Artificial Intelligence, Vol.5, pp. 1-14, 2023, DOI:10.32604/jai.2023.039786 - 08 August 2023

    Abstract Autonomous agents can explore the environment around them when equipped with advanced hardware and software systems that help intelligent agents minimize collisions. These systems are developed under the term Artificial Intelligence (AI) safety. AI safety is essential to provide reliable service to consumers in various fields such as military, education, healthcare, and automotive. This paper presents the design of an AI safety algorithm for safe autonomous navigation using Reinforcement Learning (RL). Machine Learning Agents Toolkit (ML-Agents) was used to train the agent with a proximal policy optimizer algorithm with an intrinsic curiosity module (PPO + ICM). This training… More >

  • Open Access

    ARTICLE

    New Nano Polymer Materials for Composite Exterior-Wall Coatings

    Yue Yu*

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.10, pp. 2681-2694, 2023, DOI:10.32604/fdmp.2023.028250 - 25 June 2023

    Abstract A triethylenetetramine epoxy mixture was synthesized through the reaction of a low-molecular-weight liquid epoxy resin with triethylenetetramine (TETA). Then triethyltetramine (TETA) was injected dropwise into a propylene glycol methyl ether (PM) solution for chain extension reaction. A hydrophilic and flexible polyether segment was introduced into the hardener molecule. The effects of TETA/DGEPG, reaction temperature and reaction time on the epoxy conversion of polyethylene glycol diglycidyl ether (DGEPG) were studied. In addition, several alternate strategies to add epoxy resin to the high-speed dispersion machine and synthesize MEA DGEBA adduct (without catalyst and with bisphenol A diglycidyl More >

  • Open Access

    REVIEW

    Targeting the “undruggable” cancer driver genes: Ras, myc, and tp53

    XINGBO WU, DAN PAN, SHOUYI TANG, YINGQIANG SHEN*

    BIOCELL, Vol.47, No.7, pp. 1459-1472, 2023, DOI:10.32604/biocell.2023.028790 - 21 June 2023

    Abstract The term “undruggable” is to describe molecules that are not targetable or at least hard to target pharmacologically. Unfortunately, some targets with potent oncogenic activity fall into this category, and currently little is known about how to solve this problem, which largely hampered drug research on human cancers. Ras, as one of the most common oncogenes, was previously considered “undruggable”, but in recent years, a few small molecules like Sotorasib (AMG-510) have emerged and proved their targeted anti-cancer effects. Further, myc, as one of the most studied oncogenes, and tp53, being the most common tumor suppressor genes,… More >

  • Open Access

    ARTICLE

    Real-Time Memory Data Optimization Mechanism of Edge IoT Agent

    Shen Guo*, Wanxing Sheng, Shuaitao Bai, Jichuan Zhang, Peng Wang

    Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 799-814, 2023, DOI:10.32604/iasc.2023.038330 - 29 April 2023

    Abstract With the full development of disk-resident databases (DRDB) in recent years, it is widely used in business and transactional applications. In long-term use, some problems of disk databases are gradually exposed. For applications with high real-time requirements, the performance of using disk database is not satisfactory. In the context of the booming development of the Internet of things, domestic real-time databases have also gradually developed. Still, most of them only support the storage, processing, and analysis of data values with fewer data types, which can not fully meet the current industrial process control system data… More >

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